Expression of T Helper 17 Cells Retinoid Acid Related Orphan Receptor Gammat (RORγt) mRNA in Systemic Lupus Erythematosus

2019 ◽  
Vol 27 (1) ◽  
pp. 117-123
Author(s):  
Rehab A. Mohamed ◽  
Hend M. Maghraby ◽  
Aml El-Sayed Abdou ◽  
Haneya A. A. Ali ◽  
Omnia A. El-Dydamoni ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Orphan Receptor ◽  
T Helper ◽  
Systemic Lupus ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Retinoid Acid

scholarly journals The role of dietary sodium intake on the modulation of T helper 17 cells and regulatory T cells in patients with rheumatoid arthritis and systemic lupus erythematosus

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184449 ◽  
Author(s):  
Rossana Scrivo ◽  
Laura Massaro ◽  
Cristiana Barbati ◽  
Marta Vomero ◽  
Fulvia Ceccarelli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sodium Intake ◽  
Dietary Sodium ◽  
T Helper ◽  
Systemic Lupus ◽  
T Helper 17 ◽  
T Helper 17 Cells

Down-regulation of expression of retinoid acid-related orphan receptor C (RORC) in systemic lupus erythematosus

2015 ◽  
Vol 36 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Safaa M. El-Karaksy ◽  
Hala A. Raafat ◽  
Marianne Nabil Y. Abadir ◽  
Mariam Onsy F. Hanna
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Orphan Receptor ◽  
Systemic Lupus ◽  
Down Regulation ◽  
Regulation Of Expression ◽  
Retinoid Acid

scholarly journals T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?

2014 ◽  
Vol 16 (2) ◽  
pp. R62 ◽  
Author(s):  
Zana Brkic ◽  
Odilia BJ Corneth ◽  
Cornelia G van Helden-Meeuwsen ◽  
Radboud JEM Dolhain ◽  
Naomi I Maria ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Type I ◽  
T Helper ◽  
Systemic Lupus ◽  
T Helper 17 ◽  
T Helper 17 Cell

scholarly journals Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Sonia Garcia-Rodriguez ◽  
Jose-Luis Callejas-Rubio ◽  
Norberto Ortego-Centeno ◽  
Esther Zumaquero ◽  
Raquel Ríos-Fernandez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Systemic Lupus Erythematosus ◽  
Transcription Factors ◽  
Lupus Erythematosus ◽  
Mononuclear Cells ◽  
Transforming Growth Factor ◽  
Orphan Receptor ◽  
Mitogen Activated Protein Kinase ◽  
T Helper ◽  
Systemic Lupus

Kinases have been implicated in the immunopathological mechanisms of Systemic Lupus Erythematosus (SLE). v-akt murine-thymoma viral-oncogene-homolog 1 (AKT1) and mitogen-activated-protein-kinase 1 (MAPK1) gene expressions in peripheral mononuclear cells from thirteen SLE patients with inactive or mild disease were evaluated using quantitative real-time reverse-transcription polymerase-chain-reaction and analyzed whether there was any correlation with T-helper (Th) transcription factors (TF) gene expression, cytokines, and S100A8/S100A9-(Calprotectin). Age- and gender-matched thirteen healthy controls were examined. AKT1 and MAPK1 expressions were upregulated in SLE patients and correlated with Th17-(Retinoic acid-related orphan receptor (ROR)-C), T-regulatory-(Treg)-(Transforming Growth Factor Beta (TGFB)-2), and Th2-(interleukin (IL)-5)-related genes. MAPK1 expression correlated with Th1-(IL-12A, T-box TF-(T-bet)), Th2-(GATA binding protein-(GATA)-3), and IL-10 expressions. IL-10 expression was increased and correlated with plasma Tumor Necrosis Factor (TNF)-αand Th0-(IL-2), Th1-(IL-12A, T-bet), GATA3, Treg-(Forkhead/winged-helix transcription factor- (FOXP)-3), and IL-6 expressions. FOXP3 expression, FOXP3/RORC, and FOXP3/GATA3 expression ratios were increased. Plasma IL-1β, IL-12(p70), Interferon-(IFN)-γ, and IL-6 cytokines were augmented. Plasma IL-1β, IL-6, IL-2, IFN-γ, TNF-α, IL-10, and IL-13 correlated with C-reactive protein, respectively. Increased Calprotectin correlated with neutrophils. Conclusion, SLE patients presented a systemic immunoinflammatory activity, augmented AKT1 and MAPK1 expressions, proinflammatory cytokines, and Calprotectin, together with increased expression of Treg-related genes, suggesting a regulatory feedback opposing the inflammatory activity.

scholarly journals The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus

Rheumatology ◽  
2009 ◽  
Vol 48 (12) ◽  
pp. 1491-1497 ◽  
Author(s):  
B. C.-H. Kwan ◽  
L.-S. Tam ◽  
K.-B. Lai ◽  
F. M.-M. Lai ◽  
E. K.-M. Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Systemic Lupus ◽  
Urinary Sediment
Sign in / Sign up

Export Citation Format

Share Document