scholarly journals A Population-Based Case–Control Study of Extreme Summer Temperature and Birth Defects

2012 ◽  
Vol 120 (10) ◽  
pp. 1443-1449 ◽  
Author(s):  
Alissa R. Van Zutphen ◽  
Shao Lin ◽  
Barbara A. Fletcher ◽  
Syni-An Hwang
Keyword(s):  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Summer Temperature ◽  
Control Study

scholarly journals Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects

2009 ◽  
Vol 170 (8) ◽  
pp. 975-985 ◽  
Author(s):  
Mary E. Cogswell ◽  
Rebecca H. Bitsko ◽  
Marlene Anderka ◽  
Alissa R. Caton ◽  
Marcia L. Feldkamp ◽  
...  
Keyword(s):  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Selection ◽  
Control Study

scholarly journals Maternal use of cough medications during early pregnancy and selected birth defects: a US multisite, case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e053604
Author(s):  
Yanyan Cao ◽  
Anthony Rhoads ◽  
Trudy Burns ◽  
Ryan M Carnahan ◽  
Kristin M Conway ◽  
...  
Keyword(s):  
Birth Defects ◽  
Septal Defect ◽  
Case Control Study ◽  
Intestinal Atresia ◽  
Population Based ◽  
Atrioventricular Septal Defect ◽  
Case Control ◽  
Small Intestinal ◽  
Limb Deficiency ◽  
Control Study

ObjectiveTo examine associations between maternal use of cough medications containing dextromethorphan (DM) without guaifenesin (glyceryl guaiacolate (GG)) (‘DM alone’), GG without DM (‘GG alone’) or DM +GG and major birth defects in offspring.DesignPopulation-based case–control study.SettingThe multisite, US National Birth Defects Prevention Study.ParticipantsMothers of 1644 children with neural tube defects (NTDs), 15 110 with non-NTDs, and 10 671 control children without a birth defect diagnosis.Main outcome measuresORs and 95% CIs.ResultsFor NTD analysis, 1.7% of mothers of case children and 1.2% of mothers of control children reported using DM alone, 1.1% and 0.6% GG alone, and 0.4% and 0.2% DM +GG. Respective percentages for non-NTD analysis were 2.2% and 1.9% for DM alone, 1.7% and 1.6% for GG alone, and 0.5% and 0.4% for DM +GG. For all NTDs and subtypes, adjusted OR estimates for DM alone were near the null with 95% CIs that included 1.0. Estimates (95% CI) were 1.8 (1.0 to 3.3) for GG alone and 1.8 (0.6 to 4.8) for DM +GG with all NTDs and 2.2 (1.1 to 4.3) for GG alone with spina bifida. Of the 45 adjusted OR estimates for non-NTDs, 39 ranged from 0.5 to 1.6 with 95% CIs that included 1.0. Near twofold or higher estimates (95% CI) were observed for the remainder and included 1.9 (1.0 to 3.7) for hydrocephalus, 2.9 (1.3 to 6.5) for atrioventricular septal defect and 1.8 (1.1 to 3.0) for transverse limb deficiency with DM alone; 2.1 (1.1 to 4.0) for small intestinal atresia/stenosis and 2.1 (0.9 to 4.5) for omphalocele with GG alone; and 3.2 (1.5 to 6.9) for gastroschisis with DM +GG.ConclusionsMaternal use of medications containing DM alone, GG alone or DM +GG showed positive associations with a small number of birth defects. These observations, which should be interpreted with caution due to small proportions of exposed mothers, may represent true signals or chance findings and warrant evaluation in future studies.

Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study

2020 ◽  
Vol 112 (7) ◽  
pp. 535-554
Author(s):  
Adrienne T. Hoyt ◽  
Tunu Ramadhani ◽  
Mimi T. Le ◽  
Charlie J. Shumate ◽  
Mark A. Canfield ◽  
...  
Keyword(s):  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81369 ◽  
Author(s):  
Ya Li Luo ◽  
Yu Li Cheng ◽  
Xiao Hui Gao ◽  
Shu Qin Tan ◽  
Jian Mei Li ◽  
...  
Keyword(s):  
Birth Defects ◽  
Maternal Age ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

Water Nitrates and CNS Birth Defects: A Population-Based Case-Control Study

1988 ◽  
Vol 43 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Tye E. Arbuckle ◽  
Gregory J. Sherman ◽  
Paul N. Corey ◽  
David Walters ◽  
Belinda Lo
Keyword(s):  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults

BMJ ◽  
2020 ◽  
pp. m4060
Author(s):  
Dagrun Slettebø Daltveit ◽  
Kari Klungsøyr ◽  
Anders Engeland ◽  
Anders Ekbom ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Nervous System ◽  
Cancer Risk ◽  
Birth Defects ◽  
Odds Ratio ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Chromosomal Anomalies ◽  
Risk Of Cancer ◽  
Control Study

AbstractObjectiveTo examine associations between birth defects and cancer from birth into adulthood.DesignPopulation based nested case-control study.SettingNationwide health registries in Denmark, Finland, Norway, and Sweden.Participants62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014.Main outcome measuresRelative risk of cancer in relation to major birth defects, estimated as odds ratios with 99% confidence intervals from logistic regression models.ResultsAltogether, 3.5% (2160/62 295) of cases and 2.2% (15 826/724 542) of controls were born with major birth defects. The odds ratio of cancer for people with major birth defects compared with those without was 1.74 (99% confidence interval 1.63 to 1.84). For individuals with non-chromosomal birth defects, the odds ratio of cancer was 1.54 (1.44 to 1.64); for those with chromosomal anomalies, the odds ratio was 5.53 (4.67 to 6.54). Many structural birth defects were associated with later cancer in the same organ system or anatomical location, such as defects of the eye, nervous system, and urinary organs. The odds ratio of cancer increased with number of defects and decreased with age, for both non-chromosomal and chromosomal anomalies. The odds ratio of cancer in people with any non-chromosomal birth defect was lower in adults (≥20 years: 1.21, 1.09 to 1.33) than in adolescents (15-19 years: 1.58, 1.31 to 1.90) and children (0-14 years: 2.03, 1.85 to 2.23). The relative overall cancer risk among adults with chromosomal anomalies was markedly reduced from 11.3 (9.35 to 13.8) in children to 1.50 (1.01 to 2.24). Among adults, skeletal dysplasia (odds ratio 3.54, 1.54 to 8.15), nervous system defects (1.76, 1.16 to 2.65), chromosomal anomalies (1.50, 1.01 to 2.24), genital organs defects (1.43, 1.14 to 1.78), and congenital heart defects (1.28, 1.02 to 1.59) were associated with overall cancer risk.ConclusionsThe increased risk of cancer in individuals with birth defects persisted into adulthood, both for non-chromosomal and chromosomal anomalies. Further studies on the molecular mechanisms involved are warranted.

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