scholarly journals Sex steroid hormones, bone mineral density, and risk of breast cancer.

1997 ◽  
Vol 105 (suppl 3) ◽  
pp. 593-599 ◽  
Author(s):  
L H Kuller ◽  
J A Cauley ◽  
L Lucas ◽  
S Cummings ◽  
W S Browner
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Steroid Hormones ◽  
Bone Mineral ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Mineral Density

scholarly journals Sex Steroid Hormones, Bone Mineral Density, and Risk of Breast Cancer

1997 ◽  
Vol 105 ◽  
pp. 593 ◽  
Author(s):  
Lewis H. Kuller ◽  
Jane A. Cauley ◽  
Lee Lucas ◽  
Steve Cummings ◽  
Warren S. Browner
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Steroid Hormones ◽  
Bone Mineral ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Mineral Density

scholarly journals Sex Steroid Hormones in Older Men: Longitudinal Associations with 4.5-Year Change in Hip Bone Mineral Density—The Osteoporotic Fractures in Men Study

2010 ◽  
Vol 95 (9) ◽  
pp. 4314-4323 ◽  
Author(s):  
Jane A. Cauley ◽  
Susan K. Ewing ◽  
Brent C. Taylor ◽  
Howard A. Fink ◽  
Kristine E. Ensrud ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Steroid Hormones ◽  
Sex Hormones ◽  
Bone Mineral ◽  
Older Men ◽  
Sex Steroid Hormones ◽  
Mass Action ◽  
Sex Steroid ◽  
Mineral Density ◽  
Hip Bmd

Context: There is limited information on the association between sex hormones and bone loss in older men. Objective: Our objective was to determine the longitudinal association between sex steroid hormones and bone mineral density (BMD). Design and Setting: We conducted a prospective study of 5995 men aged at least 65 yr old at six U.S. clinical centers. Participants: Sex steroid hormones were measured in a random sample of 1602 men. After exclusions, 1238 men were included in cross-sectional analyses and 969 in longitudinal analyses. Baseline sex hormones were measured using liquid chromatography-mass spectrometry. Bioavailable (Bio) estradiol (BioE2) and testosterone (BioT) were calculated from mass action equations. SHBG was measured using chemiluminescent substrate. Main Outcome Measures: BMD of the total hip, measured at baseline and once or twice afterward over 4.6 yr of follow-up, was evaluated. Results: The annualized percent change in hip BMD increased with decreasing BioE2 (P trend = 0.03). Men with the lowest BioE2 (<39.7 pmol/liter) compared with the highest BioE2 (≥66.0 pmol/liter) experienced 38% faster rate of BMD loss (P < 0.05). There was no association between BioT and hip BMD loss. Men with lowest BioE2, lowest BioT, and highest SHBG experienced a 3-fold faster rate of BMD loss compared with men with higher levels (P = 0.02). A threshold effect of SHBG was observed; the rate of hip BMD loss increased in men with SHBG of 49–60 nm. Conclusions: Low BioE2 and high SHBG levels were associated with lower BMD and faster hip BMD loss. The combination of low BioE2, low BioT, and high SHBG was associated with significantly faster rates of BMD loss.

scholarly journals Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men

2009 ◽  
Vol 70 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Channing J. Paller ◽  
Meredith S. Shiels ◽  
Sabine Rohrmann ◽  
Shehzad Basaria ◽  
Nader Rifai ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Steroid Hormones ◽  
Bone Mineral ◽  
Representative Sample ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Mineral Density ◽  
Nationally Representative ◽  
Relationship Of

Evaluation with densitometry of patients with breast cancer and low bone mineral density after 2 years of treatment

2013 ◽  
Author(s):  
Sonia Munoz Gil ◽  
Tomas Mut Dolera ◽  
Belen C Garrido Lopez ◽  
M D Torregrosa Maicas ◽  
R Girones Sarrio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Low Bone Mineral Density

Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

1996 ◽  
Vol 82 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Sandro Barni ◽  
Paolo Lissoni ◽  
Gabriele Tancini ◽  
Antonio Ardizzoia ◽  
Marina Cazzaniga
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Adjuvant Treatment ◽  
Mineral Content ◽  
Postmenopausal Breast Cancer ◽  
Mineral Density ◽  
One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

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