scholarly journals Severe Immune Thrombocytopenia Complicated by Intracerebral Haemorrhage Associated with Coronavirus Infection: A Case Report and Literature Review

Author(s):  
Mohamed Magdi ◽  
Ali Rahil

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that causes isolated thrombocytopenia. Many viruses have been identified as triggering the autoimmune process, including HIV, MCV, EBV, parvovirus, rubella and measles. However, ITP in association with coronavirus infection has not previously been reported. We describe the case of a healthy man who presented with severe ITP complicated by intracranial haemorrhage following upper respiratory tract infection. An infection screen revealed coronavirus infection.

2021 ◽  
Author(s):  
Felipe Sarlo Pezzin ◽  
Camila de Melo Perovani ◽  
Luana Marques Ribeiro ◽  
Julya Leite de Assis Pereira ◽  
Caroline Lopes Gratival ◽  
...  

Context: Benign Acute Childhood Myositis (BACM) is a self-limited syndrome of acute myalgia prevalent in calf with impaired walking after Upper Respiratory Tract Infection. This report analyze the clinical condition and investigation of BACM case, by medical record. Case report: C.L.F.A., male, 12 years, in use of clobazam, sodium divalproate, topiramate and lamotrigine, started low back pain. One day after, presented headache, fever and nasal congestion. Reported convulsive febrile episodes. At following morning received Upper Respiratory Tract Infection diagnoses. Next day, maintained symptoms and developed thrombocytopenia. Discharged due to suspicion of dengue. After 24 hours, returned with improved thrombocytopenia, also with leukopenia. At 5th day, started pain in lower limbs and impaired walking. Due to muscle symptoms worsening and increased creatinophosphokinase, hospital admission were indicated. Laboratory tests found increased in creatinekinase (10,180 U/L), CKMB (129,6 U/L), leukopenia (2800/mm3 ) and thrombocytopenia (174,000 / mm3 ). Anti-HIV, anti- leptospirosis, dengue, Chikungunya and anti-HCV tests resulted negative. At the 6th hospitalization day, he was discharged virtue of muscle symptoms, leukocytosis and creatinekinase levels favorable progression. Conclusions: BACM has excellent prognosis and self-limited course, so outpatient care is feasible. The diagnosis is clinical. If neurological deficits, modified urine tests and rash, or symptoms duration longer than one week, differential diagnoses must be researched. Measure creatinekinase is important if pain or walking disability after viral episode. Early intervention avoids complications.


PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 260-260
Author(s):  
Kozo Nishimura ◽  
Masanori Igarashi

Postinfectious thrombocytopenic purpura in children is well known, and several viral infections have been incriminated, including rubella, measles, measles vaccination, chickenpox, mumps, smallpox vaccination, infectious mononucleosis, hepatitis, cytomegalovirus infection, and upper respiratory tract infection, as reviewed by McClure in the January 1975 issue of Pediatrics (page 68). It seems that thrombocytopenic purpura following exanthema subitum is not known in the English literature. We would like to present a brief summary of five such cases we have reported previously.1


2018 ◽  
Vol 23 (1) ◽  
pp. 114-116 ◽  
Author(s):  
Matthew K. Sandre ◽  
Sonia M. Poenaru ◽  
Andrea K. Boggild

We present a patient with new-onset erythema nodosum leprosum months after successful treatment of her mid-borderline leprosy, which was likely triggered by a combination of antecedent influenza vaccination and upper respiratory tract infection.


2021 ◽  
Vol 8 (7) ◽  
pp. 1296
Author(s):  
Mallesh Kariyappa ◽  
Sahana Devadas ◽  
Aparna Dutt ◽  
Varun Govindarajan

COVID-19, a clinical syndrome caused by the coronavirus (SARS-CoV-2) became a pandemic following an outbreak of viral pneumonitis, first identified in Wuhan, China. The disease manifestations vary ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and even death. Although most of the neonatal cases are asymptomatic, rarely, they can present with cytokine storm mimicking with similar features of sepsis. This is a case report of SARS-CoV19 positive neonate presenting with sepsis and cytokine storm, 5-day old baby born to SARS-COVID 19 positive mother presented with fever and investigations showed elevated total counts with neutrophilic predominance, thrombocytopenia suggestive of sepsis and increased inflammatory markers suggestive of cytokine storm. Blood culture was sent and baby was started on intravenous antibiotics. In view of cytokine storm intravenous dexamethasone 0.5 mg/kg/day was given intravenously for 5 days. Neonate recovered from illness after 1 week as evidenced clinically and and by the fall in inflammatory markers before discharge. This report opens the possibility of having both sepsis and cytokine storm in a SARS-CoV19 positive neonate.


1997 ◽  
Vol 55 (1) ◽  
pp. 136-138 ◽  
Author(s):  
Mirian S. Bittar ◽  
Maria L. Garcia ◽  
Paulo E. Marchiori

The case of 22-year old, white woman with bilateral orbital myositis following an acute upper respiratory tract infection is reported. The most important clinical findings were ocular pain, proptosis, restricted eye motility and swelling of the eyelids. The enlarged eye muscles were seen on orbital computerized tomography scan. The clinical findings of inflammatory orbital myositis and clinical response to corticotherapy are emphasized.


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