scholarly journals Propofol-Induced Hepatitis

2020 ◽  
Author(s):  
Hanna Raisi ◽  
Thomas Longerich ◽  
Bernardo Moreira Assuncao ◽  
Sebastian Mueller ◽  
Peter Schirmacher ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Acute Hepatitis ◽  
General Condition ◽  
Rare Case ◽  
Toxic Hepatitis ◽  
Liver Stiffness ◽  
Radical Scavenger ◽  
Liver Necrosis ◽  
Good General Condition ◽  
Acetyl Cysteine

Objectives:To present a rare case of propofol-induced hepatitis. Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy.  Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition. Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.

Reliability of Transient Elastography as a non-Invasive Technique for Detection of Fibrosis in Budd Chiari Syndrome Patients after Endovascular Intervention

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohammed F Montasser ◽  
Eman M Barakat ◽  
Mohamed S Ghazy ◽  
Sara M Abdelhakam ◽  
Hend E Ebada ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Endovascular Intervention ◽  
Invasive Technique ◽  
Budd Chiari Syndrome ◽  
Metavir Score ◽  
Before And After ◽  
Chiari Syndrome

Abstract Aim of the work To test the reliability of fibroscan in detection of fibrosis in patients with Budd Chiari syndrome before and after endovascular intervention (after elimination of hepatic congestion). Background transient elastography (TE) is a noninvasive methodology that has been used to monitor liver stiffness in patients with chronic viral hepatitis. One of the limitations for accurate assessment of liver fibrosis by TE is the liver congestion. Liver congestion can result from Budd Chiari syndrome (BCS).The treatment of BCS is through restoring the flow of the blood between the portal vein to the inferior vena cava, which will lead to decongestion of the liver.TE, will be tested after liver decongestion for proper detection of liver fibrosis. Patients and methods This was a prospective cohort study conducted on 25 Egyptian patients with confirmed diagnosis of primary Budd-Chiari Syndrome (BCS) in the period from June 2017 to September 2019. TE was performed three days before endovascular intervention and three months after it. Liver biopsy was taken during the intervention for assessment of METAVIR score. Comparison was done between TE assessments before and after intervention in detection of the degree of liver fibrosis in comparison to METAVIR score measured in liver biopsy. Results FVLM was the most common hypercoagulable cause in the involved patients. There was significant drop in Liver Stiffness Measurements (LSM) measured three months post-intervention indicating improvement of liver fibrosis after relieving liver congestion but still not correlated to the METAVIR scores measured in the liver biopsy. Conclusion Liver congestion has high impact on Liver stiffness measurement giving overestimation which improves significantly after decongestion of the liver by the endovascular intervention.

scholarly journals Microsurgical DREZ lesions for the control of cancer-related pain

2020 ◽  
Vol 3 (2) ◽  
pp. V14 ◽  
Author(s):  
Edoardo Mazzucchi ◽  
Andrei Brinzeu ◽  
Patrick Mertens ◽  
Marc Sindou
Keyword(s):  
General Condition ◽  
Dorsal Root ◽  
Lateral Part ◽  
Entry Zone ◽  
Dorsal Root Entry Zone ◽  
Patients With Cancer ◽  
Root Entry Zone ◽  
Refractory Pain ◽  
Pain Pathways ◽  
Good General Condition

Pain in patients with cancer is a major problem, and sometimes it is necessary to surgically interrupt pain pathways to effectively control refractory pain. Surgical lesion of the dorsal root entry zone (DREZ) was first performed in 1972 for the treatment of pain related to a Pancoast-Tobias tumor. The rationale of DREZotomy is to preferentially interrupt the nociceptive inputs in the lateral part of the DREZ and the ventrolateral (excitatory) part of the dorsal horn. Microsurgical DREZotomy is one technique for DREZ lesioning that is suited for tailored control of pain in patients in good general condition who are experiencing pain in a well-defined territory.The video can be found here: https://youtu.be/JtLQDP7gYSQ

Liver biopsy features of acute hepatitis C compared with hepatitis A, B, and non-A, non-B, non-C

2008 ◽  
Vol 13 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Kiyomasa Kobayashi ◽  
Etsuko Hashimoto ◽  
Jürgen Ludwig ◽  
Toju Hisamitsu ◽  
Hiroshi Obata
Keyword(s):  
Hepatitis C ◽  
Liver Biopsy ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Acute Hepatitis C

THE USE OF THE SERUM GLUTAMIC PYRUVIC TRANSAMINASE TEST FOR THE EVALUATION OF HEPATIC NECROTROPIC COMPOUNDS IN RATS

1962 ◽  
Vol 40 (1) ◽  
pp. 1-6 ◽  
Author(s):  
T. Balazs ◽  
J. M. Airth ◽  
H. C. Grice
Keyword(s):  
Toxic Hepatitis ◽  
Glutamic Pyruvic Transaminase ◽  
Liver Necrosis ◽  
Serum Glutamic Pyruvic Transaminase ◽  
Positive Correlation

A positive correlation was established between the extent of liver necrosis, measured planimetrically, and the serum glutamic pyruvic transaminase (SGPT) level in toxic hepatitis. Intoxicated rats treated with necrotropic drugs showed significantly lower SGPT values than the control animals. The measurement of SGPT level in toxic hepatitis in rats is suggested as a method for evaluation of hepatic necrotropic compounds.

scholarly journals New size record for Snapping Turtle (Chelydra serpentina) in southern Quebec, Canada

2019 ◽  
Vol 132 (4) ◽  
pp. 378-381
Author(s):  
Patrick Galois ◽  
Ève-Lyne Grenier ◽  
Martin Ouellet
Keyword(s):  
Population Structure ◽  
Adult Male ◽  
General Condition ◽  
Carapace Length ◽  
Maximum Size ◽  
Chelydra Serpentina ◽  
Snapping Turtle ◽  
Good General Condition ◽  
Turtle Population ◽  
Local Habitat

We report a new size record for a Snapping Turtle (Chelydra serpentina) in Quebec, Canada. We captured an adult male in good general condition in the Rivière du Sud in the southern Montérégie region. Its straight midline carapace length was 43.2 cm (maximum carapace length 45.1 cm), and it weighed 19.8 kg. This record contributes to our understanding of the maximum size of this species at the northeastern part of its range. More intensive effort will be necessary to document the Snapping Turtle population structure in Quebec to allow for sound comparisons with other populations, as well as a better understanding of the effects of elevation, latitude, and local habitat on Snapping Turtle growth and size.

Liver stiffness measurements in acute hepatitis B: implications for clinical practice

2010 ◽  
Vol 22 (2) ◽  
pp. 133-134 ◽  
Author(s):  
Simon D. Taylor-Robinson ◽  
Jeremy F.L. Cobbold ◽  
Howard C. Thomas
Keyword(s):  
Clinical Practice ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Liver Stiffness ◽  
Acute Hepatitis B

scholarly journals Acute Hepatitis after Ingestion of a Preparation of Chinese Skullcap and Black Catechu for Joint Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Charilaos Papafragkakis ◽  
Mel A. Ona ◽  
Madhavi Reddy ◽  
Sury Anand
Keyword(s):  
Side Effects ◽  
Acute Hepatitis ◽  
Joint Pain ◽  
Toxic Hepatitis ◽  
Herbal Preparations ◽  
Wide Range ◽  
Herbal Medications ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Many herbal preparations are routinely used and have been occasionally associated with a wide range of side effects, from mild to severe. Chinese skullcap and black catechu are herbal medications commonly used for their hepatoprotective and other properties. We report a case of acute toxic hepatitis associated with ingestion of Chinese skullcap and black catechu in one preparation for the alleviation of joint pain.

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