Comparison between Self-reported and Objective Measures on Speech Characteristics in Patients with Parkinson’s Disease

The present study examined the effects of neurosurgical management of Parkinson’s disease (PD), including the procedures of pallidotomy, thalamotomy, and deep-brain stimulation (DBS) on perceptual speech characteristics, speech intelligibility, and oromotor function in a group of 22 participants with PD. The surgical participant group was compared with a group of 25 non-neurologically impaired individuals matched for age and sex. In addition, the study investigated 16 participants with PD who did not undergo neurosurgical management to control for disease progression. Results revealed that neurosurgical intervention did not significantly change the surgical participants’ perceptual speech dimensions or oromotor function despite significant postoperative improvements in ratings of general motor function and disease severity. Reasons why neurosurgical intervention resulted in dissimilar outcomes with respect to participants’ perceptual speech dimensions and general motor function are proposed.

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Can Objective Measurements Improve Treatment Outcomes in Parkinson’s Disease?

European Neurological Review ◽

10.17925/enr.2014.09.01.27 ◽

2014 ◽

Vol 9 (1) ◽

pp. 27 ◽

Cited By ~ 6

Author(s):

Filip Bergquist ◽

Malcolm Horne ◽

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Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Daily Activities ◽

Objective Measures ◽

Motor Symptoms ◽

Improve Quality ◽

Improve Treatment ◽

Economic Justification

Many examples in medicine show that therapies are most effective when measurement is used to guide their implementation, dose and effects. There are effective symptomatic therapies for the motor symptoms of Parkinson’s disease, which improve quality of life and have a health economic justification for their subsidisation. As measurement should lead to more effective deployment of these therapies, even in a percentage of cases, then costs of therapy would be reduced and by that percentage. We conclude that there is a clear need or continuous objective measures of dyskinesia and bradykinesia while patients go about their normal daily activities. The benefit of measurement would be greatest if these measures were directed at treating fluctuations.

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Biomarker research in Parkinson’s disease: objective measures needed for patient stratification in future cause-directed trials

Biomarkers in Medicine ◽

10.2217/bmm.10.93 ◽

2010 ◽

Vol 4 (5) ◽

pp. 647-650 ◽

Cited By ~ 11

Author(s):

Michael G Schlossmacher ◽

Brit Mollenhauer

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Objective Measures ◽

Patient Stratification ◽

Biomarker Research

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A preliminary study of the effects of sub thalamic nucleus (STN) deep brain stimulation (DBS) on voice and speech characteristics in Parkinson's Disease (PD)

Clinical Linguistics & Phonetics ◽

10.1080/026992001461389 ◽

2001 ◽

Vol 15 (1) ◽

pp. 97-101 ◽

Cited By ~ 4

Author(s):

Bari Hoffman-Ruddy, Geralyn Schulz, Jear

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Brain Stimulation ◽

Brain Stimulation ◽

Thalamic Nucleus ◽

Speech Characteristics ◽

Preliminary Study ◽

Deep Brain ◽

Voice And Speech

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Objective measures for the progression of Parkinson's disease

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.74.3.287 ◽

2003 ◽

Vol 74 (3) ◽

pp. 287-288 ◽

Cited By ~ 4

Author(s):

B Snow

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Objective Measures

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The Relationship Between Speech Characteristics and Motor Subtypes of Parkinson's Disease

American Journal of Speech-Language Pathology ◽

10.1044/2020_ajslp-20-00058 ◽

2020 ◽

Vol 29 (4) ◽

pp. 2145-2154

Author(s):

Katherine A. Brown ◽

Kristie A. Spencer

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Rating Scale ◽

Pause Duration ◽

Speech Sample ◽

Frequency Range ◽

Speech Characteristics ◽

Disease Rating ◽

Cepstral Peak Prominence ◽

The Relationship

Purpose The aim of this study was to examine whether acoustic dysarthria characteristics align with overall motor profile in individuals with Parkinson's disease (PD). Potential speech differences between tremor-dominant and non–tremor-dominant subtypes are theoretically motivated but empirically inconclusive. Method Twenty-seven individuals with dysarthria from PD provided a contextual speech sample. Participants were grouped into non–tremor-dominant ( n = 12) and tremor-dominant ( n = 15) motor subtypes according to the Unified Parkinson Disease Rating Scale. Dependent speech variables included fundamental frequency range, average pause duration, cepstral peak prominence, stuttering dysfluencies, and maze dysfluencies. Results There were no significant differences between the speech of the tremor-dominant and non–tremor-dominant groups. High within-group variability existed across parameters and motor subtypes. Conclusion Speech characteristics across the areas of phonation, prosody, and fluency did not differ appreciably between PD motor subtypes.

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