CLINICAL AND ECONOMIC JUSTIFICATION OF SOFTWARE SCREENING PERFORMANCE OF COLORECTAL CANCER AT THE REGION LEVEL

The aim of the study is to assess the clinical and economic effectiveness of the practical implementation results of programmed screening for colorectal cancer (CRC) in the Primorsky Territory using clinical and economic research methods.Materials and methods. In the study, the following kinds of data were used: the statistical data from the regional clinic’s cancer registry on the structure of the morbidity and average life expectancy of CRC patients in the Primorsky Territory; the data on the cost of screening studies and the stages of anticancer therapy in accordance with the “Territorial Tariff Agreement on Payment for Medical Care (Medical Services) in the System of Compulsory Health Insurance in the Territory of Primorsky Krai”, 2021. Two methods of clinical and economic analysis with the corresponding calculation formulas have been applied. The cost of medical interventions were estimated in accordance with the screening standards and clinical guidelines for the treatment of malignant neoplasms of the colon and rectum, approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation, 2020.Results. The evidence-based substantiation of screening clinical effects has been obtained: the structure redistribution of colorectal cancer incidence towards the prevalence of early forms by 16.81%; the average increase in the life expectancy of patients with the studied disease is 12.8 months. A natural consequence of these events is the predicted decrease in the mortality rate from CRC in the territory of the subject in the subsequent years. The economic justification of CRC screening software which guarantees a significant saving in health care resources amounting to 23% compared to an alternative strategy, has been demonstrated. It can influence the management decisions on the further strategy of the mass introduction of this medical technology.Conclusion. Currently, CRC screening is the most effective way to reduce morbidity and mortality from this disease. The predominance of the early diagnosis of the disease is extrapolated to significant savings in public health care. A promising direction for further research in the field of CRC screening is the study of its long-term effects, in particular, a detailed clinical and economic analysis of the diagnostics effectiveness and the elimination of premalignant neoplasms.

ASSESSMENT OF THE QUALITY OF THE ASSET POOL FORMED FOR SECURITIZATION IN THE CONTEXT OF ANALYTICAL PROVISION OF THE MANAGEMENT SYSTEM

The lack of an effective methodology for the analysis of asset securitization operations causes problems in the formation of a strategy for managing the process of financing the activities of the initiator of the securitization. The article substantiates the areas of analytical support of the management system in terms of asset securitization: the formation of financial and economic justification of the feasibility and feasibility of securitization of assets (study of potential investors and analysis of prospects for placement of securities; diligence); assessment of the original assets of the originator for the possibility of their securitization; identification of the impact of securitization of assets on the financial performance of the originator; assessment of risks associated with the use of securitization of assets); analysis of the quality of the asset pool generated by the originator for securitization; evaluation of the effectiveness of securitization operations for its initiator. It is also proposed to analyze the quality of the pool of assets generated by the originator for securitization, in the following sequence: assessment of the probability of default and the amount of expected losses on the pool of assets to be securitized; identification of factors influencing the early repayment of pool assets; assessment of the parameters of the formed pool of securitized assets, based on the analysis of its structure and the selected system of indicators; modeling of future payment flows in the pool of securitized assets, which provides the formation of analytical information to decide on the possibility of securitization using the assets available in the originator and diversification of risks through optimal concentration of assets.

Ecological-and-economic aspects of city-planning

The purpose of this research is to consider ecological-and-aspects of the land use during arrangement and planning of the urban areas on the basis of the assessment of city-planning components of various districts of the city. The authors offer some measures for the improvement of nature protection activity in the structure of the urban area management. The factors, determining planning of the city structures, key indicators of information support for the adoption of the city-planning decision, the principles of engineering-and-ecological zoning were revealed in the articles. The authors offered to carry out management of the territory and granting the land plots step by step, for the purpose of their effective ecological-and-economic use. The provisions, offered by the authors in this article, can be applied for ecological-and-economic justification of projects of the use of city lands as well as for the development of methodical recommendations on the effective arrangement of the built-up territories.

Economic Analysis of a Pumped Storage Project for Iran Generating System Based on a Dynamic Modeling

This paper proposes a dynamic model for evaluation of a Pumped Storage Project (PSP) . The optimal expansion policy is determined by considering different alternatives (Types of units: Rodbar PSP(RPSP), Steam Turbine , 2 types of Gas Turbine and a Combined Cycle) . Based on this model dynamic assessment of different alternatives (over a 20 years period and with a target Loss Of Load Probability (LOLP)) provides economic justification for RPSP.

Viable Supply Chain Network Design by considering Blockchain Technology and Cryptocurrency

Nowadays, using Blockchain Technology (BCT) is growing faster in each country. It is essential to apply BCT in Supply Chain Network Design (SCND) and is considered by the designer and manager of SC. This research indicates Viable Supply Chain Network Design (VSCND) by applying BCT. A new form of two-stage robust optimization is suggested. Facility locations and activation BCT for VSCND is the first stage of decisions; finally, we determine flow transshipment between components in the next stage. The GAMS-CPLEX is used for solving the model. The results show that running BCT will decrease 0.99% in costs. There is an economic justification for using BCT when demand is high. A fix-and-optimize and Lagrange relaxation (LR) generate lower and upper bound to estimate large scale in minimum time. The gap between the main model and fix-and-optimize is better than the LR algorithm. Finally, this research suggests equipping VSCND by BCT that becomes more resilient against demand fluctuation, sustainable, and agile.

The functionality of informal trade in the creation of political power

This article delves into the analysis of informal commerce as a means of power created from the street vendor's perspective. This paper aims to evaluate the expressions of the itinerant executors of the practice of informal trade as a means of creating power. To do this, the conception of analysis, using the local practices referring to informal trade, were analyzed as a means of economic sustenance and in the same way, understood among selected groups as illegal. However independent of the local context and the established place. The thesis that follows is that the street trade has a functional character in the obtaining of power by groups; ideological promotion and not just an economic justification. The main findings and results of the research demonstrated that the decisions of the executors of the practice are permeated by a motivation for the illegal practice, which wanders between what is economically necessary and politically permissible. The situation that determines the functionality and applicability of informal trade acts, underestimates compliance with the existence of local trade policies and regulations of social life and instead, they are recognized as legitimate as they belong to groups of political control. Therefore, it contributes to the defense of the hypothesis, based on demonstrating that the practice of ambulance is presented as a valve for attention to unemployment, while it is tolerated as a means of opportunity to the creation of political power independent of the local or regional context.

Application of parametric standardization in the calculation of rows of hydraulic cylinder diameters

Currently, the ordering of standardization objects and their properties, optimization of the parameters of standardization objects, normalization of requirements for objects are the most important areas of standardization as a science. In this regard, the issues of choosing parametric series are very relevant. In order to increase the level of interchangeability and reduce the range of products and standard sizes of blanks, overall cutting tools, tooling, productivity, speed, speed, power, etc., used in a particular industry, as well as to create conditions for effective specialization and cooperation of plants, reduce the cost of products, the principle of preference is used in the unification and development of standards. There are two methods for choosing parametric series: the method of technical justification and the method of economic justification. The technical method is easier to use and is used to expand the technologies of unification of standard sizes of parts of homogeneous products. This method was used to calculate a number of diameters of hydraulic cylinders of broaching machines of the same series based on the mathematical dependence between the force developed on the hydraulic cylinder rod, which is formed by the initial parametric series laid down by the designers. As a result of technical optimization of the choice of the parametric series, a number of diameters of hydraulic cylinders R20/2(45-224) mm was installed, fully corresponding to the main functional parameter - a number of forces on the rod of broaching machines R10/2(0.63-16.0) kN.

An assessment of innovation in economic sectors of the Pridneprovsky Economic Region in Ukraine

The article provides a comparative assessment of the innovativeness of Ukrainian and Polish manufacturing. The main types and kinds of innovation in different sectors of the Pridneprovsky Economic Region are identified and each kind of economic activity in the region is rated in terms of intensity and efficiency of development. It was found out that the most promising sector of the Pridneprovsky Economic Region was the engineering industry, where innovation is based on engineering developments and research. The authors provide economic justification for measures to increase intensity and efficiency, and hence the level of innovation of key economic activities of the region. What is required is an innovation-oriented ecosystem that provides conditions for research and development, the formation and development of networks that consolidate activities of research centers and science-intensive industrial production, training of professional staff; reliable protection of intellectual property, the development of industrial clusters; that facilitate access to global sources of technology, knowledge and highly qualified engineering and technical personnel.

Examination of the influence of conjugated linoleic acid in broiler nutrition on the economic efficiency of fattening

The aim of this study was to examine the influence of the use of CLA (2%), from days 1, 11 or 22 of fattening, on selected production results (broiler weight after each fattening phase including at the end of fattening, viability, average daily gain and feed conversion) on the efficiency of fattening during the whole fattening period (42 days). The obtained production results were used to calculate the European production efficiency factor (EPEF) and the European broiler index (EBI) values for each fattening phase as well as for the whole fattening. The results obtained indicate that, in the later stages of fattening, the use of CLA during the whole fattening period is economically more justified than the non-CLA diets used for control broilers. With the use of CLA throughout the whole fattening, the EPEF and EBI values are consistent with these values calculated for the Cobb 500 standard. In addition to economic justification, the use of CLA also has human nutritional significance, since the broiler meat is enriched with CLA and has a more favourable n-6/n-3 fatty acid ratio.