Efficacy and safety of a porcine peritoneum-derived matrix in diabetic foot ulcer treatment: a pilot study

2021 ◽  
Vol 30 (Sup2) ◽  
pp. S18-S23
Author(s):  
Omar Ai-Jalodi ◽  
Matthew Sabo ◽  
Keyur Patel ◽  
Neal Bullock ◽  
Laura Serena ◽  
...  
Keyword(s):  
Pilot Study ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Study Endpoint ◽  
Efficacy And Safety ◽  
Small Pilot Study ◽  
Delay In Diagnosis ◽  
Wound Matrix

Objective: A third of people with diabetes will develop a foot ulcer during their lifetime. The absence of pain secondary to neuropathy often leads to a delay in diagnosis and treatment. Diabetic foot ulcer (DFU) complications, such as infection and amputation, increase mortality and strain the financial resources of health systems across the world. Cellular and/or tissue products (CTPs) have played an important role in the closure of DFUs. Investigators continue to search for new CTPs that facilitate healing. The aim of this study was to assess the efficacy and safety of a porcine peritoneum-derived matrix in DFU treatment. Method: Patients with longstanding DFUs participated in this institutional review board-approved, multicentre, prospective pilot study evaluating the time to healing over 12 weeks. In addition to weekly assessments for wound size, investigators analysed bacterial burden using the MolecuLight procedure (MLiX) and bacterial protease (BPA) testing. Participants received a weekly application of Meso Wound Matrix Scaffold (MWM), a lyophilised porcine peritoneum-derived matrix (DSM Biomedical Inc., Exton, PA, US) for up to eight weeks. Descriptive statistics were chosen for this analysis. Results: A total of 12 male patients and three female patients with an average age of 57 years were enrolled over a two-month period. The average wound duration was 30 weeks. Due to unrelated health issues, four participants were withdrawn. For the study endpoint of complete wound closure at 12 weeks, six (55%) of the remaining 11 patients achieved complete closure, and four (36%) patients healed during the 8-week treatment period. The average number of CTP applications was six. Patients who healed all had negative BPA by nine weeks and no fluorescence on MLiX, indicating low bacterial load. Conclusion: This small pilot study indicates that patients with longstanding DFUs may respond to a porcine peritoneal-derived CTP. In this study, the CTP appears to have inhibited bacterial growth in the wound; however, further research is needed.

Effects of Santyl® ointment with OASIS® Tri-Layer wound matrix on a diabetic foot ulcer: A case report

The Foot ◽  
2013 ◽  
Vol 23 (2-3) ◽  
pp. 113
Author(s):  
Kunal Amin ◽  
Jalpen Patel ◽  
Anthony Iorio
Keyword(s):  
Case Report ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Matrix

scholarly journals Management of Diabetic Foot Ulcer in a Tertiary Level Hospital-Faridpur

2019 ◽  
Vol 34 (1) ◽  
pp. 52-57
Author(s):  
AL Gaddafi ◽  
DK Das ◽  
G Faruque ◽  
Z Islam ◽  
MA Rahman ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Diabetic Foot ◽  
Care Center ◽  
Tertiary Care ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Surgical Interventions ◽  
Delay In Diagnosis

A descriptive type of cross sectional study among 210 diabetic patients with foot ulcer was carried out in Diabetic Association Medical College during the period of May 2016 to April 2017 and were categorized based on Meggitt-Wagner system to find out the complications, management, below knee amputation rate and mortality rate. The aim of this study was to practise a profile of diabetic foot ulcer (DFU), complications and its management to assess the outcome of the surgical interventions. Majority of the patients were male 112(53%), and most of them 116 patients (55.23%) presented within Wegner grade - 2 and grade-3 diabetic foot ulcers. The duration of diabetes more than 10 years was 116 (55%). 99 (47%) patients out of 210 patients developed diabetic neuropathy. 76 (36%) patients presented with CKD. Lack of awareness about diabetes mellitus and its lower limb complications, poor compliance to the treatment, poorly controlled blood sugar levels, delay in diagnosis, and late presentation to the tertiary care center, associated habit of smoking are all factors which lead to incidence of DFU at an earlier age than that seen in other studies. After admission of diabetic foot ulcer patients, diabetic foot ulcer is classified according to Wagner grading and treated the diabetic foot ulcer patients as the using protocol ’!1.Assesment whether it was conservative or surgical. 2. Optimal blood sugar control. 3. Systemic antibiotic. 4. Moist wound environment. 5. Offloading such as total contact casting. 6. Improves peripheral arterial circulation due to lack of vascularity. 7. Surgical debridement or minor amputation or major amputation. In case of G-4 or G-5 patients, ischemia was treated before debridement or amputation so that vascular circulation improved in the ulcer area and then healing potential was fastened. Bangladesh Heart Journal 2019; 34(1) : 52-57

scholarly journals Nano‐hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study

2019 ◽  
Vol 17 (2) ◽  
pp. 485-490 ◽  
Author(s):  
Giuseppe Gallelli ◽  
Erika Cione ◽  
Raffaele Serra ◽  
Antonio Leo ◽  
Rita Citraro ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Pilot Study ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
New Formulation

scholarly journals Antimicrobial susceptibility pattern in diabetic foot ulcer: A pilot study

2014 ◽  
Vol 4 (5) ◽  
pp. 742 ◽  
Author(s):  
SM Sekhar ◽  
N Vyas ◽  
MK Unnikrishnan ◽  
GS Rodrigues ◽  
C Mukhopadhyay
Keyword(s):  
Pilot Study ◽  
Antimicrobial Susceptibility ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Susceptibility Pattern ◽  
Antimicrobial Susceptibility Pattern

scholarly journals Clinical and Antimicrobial Efficacy of a Silver Foam Dressing With Silicone Adhesive in Diabetic Foot Ulcers With Mild Infection

2019 ◽  
Vol 18 (3) ◽  
pp. 269-278 ◽  
Author(s):  
José Luis Lázaro-Martínez ◽  
Francisco Javier Álvaro-Afonso ◽  
David Sevillano-Fernández ◽  
Raúl Juan Molines-Barroso ◽  
Yolanda García-Álvarez ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Period ◽  
Diabetic Foot ◽  
Bacterial Load ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Microbiological Analysis ◽  
Diabetic Foot Ulcers ◽  
Silicone Adhesive

The use of an antimicrobial dressing instead of a non-antimicrobial dressing may increase the number of diabetic foot ulcers healed over a medium-term follow-up period. The study aim was to evaluate the clinical and microbiological efficacy of a silver foam dressing in the management of diabetic foot ulcers. We conducted a single-center, prospective, open, noncontrolled study involving 21 outpatients with diabetic foot ulcers with mild infection. All patients received standard of care for their wounds and a silver foam dressing with silicone adhesive was applied twice per week for wound management during a 6-week treatment period. Soft tissue punch biopsies were taken every second week for qualitative and quantitative microbiological analysis. Wounds were assessed at patient admission, and wound bed tissue was evaluated for presence, quality, and consistency of granulation tissue. Clinical evaluation revealed improvements in wound conditions as a result of treatment with the silver dressing. Wollina wound scores improved significantly, from a mean score of 3.9 ± 1.6 points at inclusion to 6.1 ± 1.3 points at the end of the study (n = 19, P < .001). Treatment with the silver dressing resulted in significant decreases in the bioburden of classically considered diabetic foot ulcer pathogenic organisms such as Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, Enterobacteriaceae species, Pseudomonas aeruginosa, and other nonfermenting gram-negative bacilli. Findings revealed that the use of silver foam dressing significantly reduced the pathogenic bacterial load and markedly improved the clinical outcome in patients with diabetic foot ulcer with mild infection over a 6-week treatment period.

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