Sutton’s Thunder Stolen

2020 ◽  
pp. 59-67
Author(s):  
Gavin Weightman
Keyword(s):  
Perceived Health ◽  
Small Doses ◽  
Smallpox Inoculation ◽  
As If

This chapter addresses how Daniel Sutton's success was never properly acknowledged by his rivals, who quietly went about the business of figuring out how he did it while sneering at his lowly origins. The eminent, fully qualified doctors who sought to discover Sutton's secrets rarely mentioned him or his family of inoculators by name. They were invariably referred to as 'a certain family', as if to identify them would be to bestow a dignity on them that they really did not deserve. After all, the Suttons probably had no idea themselves how they had more or less perfected the art of smallpox inoculation. There was no published theory nor any description. A London doctor, Thomas Ruston, concluded in his research that the chief ingredient was calomel. Calomel played an important part in Suttonian inoculation, administered in small doses, the quantity dependent on the age and perceived health of the patient.

Review of the Radiation Damage Problem of Organic Specimens in Electron Microscopy

1973 ◽  
Vol 31 ◽  
pp. 476-477
Author(s):  
L. Reimer
Keyword(s):  
Electron Microscopy ◽  
Radiation Damage ◽  
Irradiation Time ◽  
Dose Effect ◽  
Primary Process ◽  
Thin Specimen ◽  
Secondary Damage ◽  
Small Doses ◽  
Micro Organisms ◽  
Damage Processes

Most information about a specimen is obtained by elastic scattering of electrons, but one cannot avoid inelastic scattering and therefore radiation damage by ionisation as a primary process of damage. This damage is a dose effect, being proportional to the product of lectron current density j and the irradiation time t in Coul.cm−2 as long as there is a negligible heating of the specimen.Therefore one has to determine the dose needed to produce secondary damage processes, which can be measured quantitatively by a chemical or physical effect in the thin specimen. The survival of micro-organisms or the decrease of photoconductivity and cathodoluminescence are such effects needing very small doses (see table).

Improvement of an artificial test substrate technique for evaluation of em immunocytochemical labeling

1987 ◽  
Vol 45 ◽  
pp. 762-763
Author(s):  
G. D. Gagne ◽  
M. F. Miller
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Artificial Substrate ◽  
Chemical Fixation ◽  
As If

We recently described an artificial substrate system which could be used to optimize labeling parameters in EM immunocytochemistry (ICC). The system utilizes blocks of glutaraldehyde polymerized bovine serum albumin (BSA) into which an antigen is incorporated by a soaking procedure. The resulting antigen impregnated blocks can then be fixed and embedded as if they are pieces of tissue and the effects of fixation, embedding and other parameters on the ability of incorporated antigen to be immunocyto-chemically labeled can then be assessed. In developing this system further, we discovered that the BSA substrate can also be dried and then sectioned for immunolabeling with or without prior chemical fixation and without exposing the antigen to embedding reagents. The effects of fixation and embedding protocols can thus be evaluated separately.

Leisure Activities and the Subjective Well-Being of Older Adults in Croatia

GeroPsych ◽  
2018 ◽  
Vol 31 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Ljiljana Kaliterna Lipovčan ◽  
Tihana Brkljačić ◽  
Zvjezdana Prizmić Larsen ◽  
Andreja Brajša-Žganec ◽  
Renata Franc
Keyword(s):  
Older Adults ◽  
Leisure Activities ◽  
Leisure Activity ◽  
Later Life ◽  
Perceived Health ◽  
Well Being ◽  
Hierarchical Regression ◽  
Subjective Well Being ◽  
Convenience Sample ◽  
Financial Status

Abstract. Research shows that engagement in leisure activities promotes well-being among older adults. The objective of the current study was to examine the relationship between subjective well-being (flourishing) and leisure activities (total number of different activities in the previous year) in a sample of older adults in Croatia, thereby considering the variables of sex, marital status, financial status, and self-perceived health. The differences in the examined variables between the groups of older adults who reported to be engaged in new activities with those who did not were also examined. The sample of N = 169 older adults aged 60 years and above was drawn from a convenience sample of adult internet users in Croatia. Participants reported their self-perceived health and the number of leisure activities they engaged in over the previous year as well as completing the Flourishing Scale. Hierarchical regression analyses indicated that older adults who were engaged in more various leisure activities, who perceived better financial status, and who were married reported higher levels of flourishing. A comparison of the two groups of older adults with and without engagement in leisure activities showed that those engaged in at least one leisure activity were more likely to be women, reported higher levels of flourishing, and perceived their own financial status as better. This study indicated that engaging in leisure activities in later life might provide beneficial effects for the well-being of older adults.

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