In-vivo imaging of bone structure dynamics based on synchrotron phase-contrast micro-CT and its application to bone defect repair in mice

2017 ◽  
Vol 2017.55 (0) ◽  
pp. K0108
Author(s):  
Ryota SHIMIZU ◽  
Takeshi MATSUMOTO
Keyword(s):  
Bone Defect ◽  
In Vivo Imaging ◽  
Phase Contrast ◽  
Bone Structure ◽  
Micro Ct ◽  
Bone Defect Repair ◽  
Structure Dynamics ◽  
Defect Repair

scholarly journals The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7708-7717 ◽  
Author(s):  
Rong Zhou ◽  
Hai-Jian Ni ◽  
Jin-Hui Peng ◽  
Ning Liu ◽  
Shu Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Bone Defect ◽  
High Performance ◽  
Calcium Phosphates ◽  
Sustained Drug Release ◽  
Bone Defect Repair ◽  
Defect Repair

Calcium phosphate modified tantalum scaffolds displayed high performance on mineralization, sustained drug release and in vivo bone defect repair.

scholarly journals The immunogenic reaction and bone defect repair function of ε-poly-L-lysine (EPL)-coated nanoscale PCL/HA scaffold in rabbit calvarial bone defect

2021 ◽  
Vol 32 (6) ◽  
Author(s):  
Bin Tian ◽  
Na Wang ◽  
Qingsong Jiang ◽  
Lijiao Tian ◽  
Lei Hu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Defect ◽  
Macrophage Infiltration ◽  
T Helper ◽  
Calvarial Bone ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Calvarial Bone Defect ◽  
Helper Type

AbstractTissue engineering is a promising strategy for bone tissue defect reconstruction. Immunogenic reaction, which was induced by scaffolds degradation or contaminating microorganism, influence cellular activity, compromise the efficiency of tissue engineering, or eventually lead to the failure of regeneration. Inhibiting excessive immune response through modulating scaffold is critical important to promote tissue regeneration. Our previous study showed that ε-poly-L-lysine (EPL)-coated nanoscale polycaprolactone/hydroxyapatite (EPL/PCL/HA) composite scaffold has enhanced antibacterial and osteogenic properties in vitro. However, the bone defect repair function and immunogenic reaction of EPL/PCL/HA scaffolds in vivo remains unclear. In the present study, three nanoscale scaffolds (EPL/PCL/HA, PCL and PCL/HA) were transplanted into rabbit paraspinal muscle pouches, and T helper type 1 (Th1), T helper type 2 (Th2), T helper type 17 (Th17), and macrophage infiltration were analyzed after 1 week and 2 weeks to detect their immunogenic reaction. Then, the different scaffolds were transplanted into rabbit calvarial bone defect to compare the bone defect repair capacities. The results showed that EPL/PCL/HA composite scaffolds decreased pro-inflammatory Th1, Th17, and type I macrophage infiltration from 1 to 2 weeks, and increased anti-inflammatory Th2 infiltration into the regenerated area at 2 weeks in vivo, when compared to PCL and PCL/HA. In addition, EPL/PCL/HA showed an enhanced bone repair capacity compared to PCL and PCL/HA when transplanted into rabbit calvarial bone defects at both 4 and 8 weeks. Hence, our results suggest that EPL could regulate the immunogenic reaction and promote bone defect repair function of PCL/HA, which is a promising agent for tissue engineering scaffold modulation.

scholarly journals In Vivo and in Vitro Studies of the Effect of Chitosan on the Bone Defect Repair Process

2016 ◽  
Vol 16 (2) ◽  
pp. 171-179 ◽  
Author(s):  
I. V. Zudina ◽  
◽  
A. P. Vedyaeva ◽  
P. V. Ivanov ◽  
A. F. A. Alzubaidi ◽  
...  
Keyword(s):  
Bone Defect ◽  
Repair Process ◽  
In Vitro Studies ◽  
Bone Defect Repair ◽  
Defect Repair

scholarly journals In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77578 ◽  
Author(s):  
Nitin Sagar ◽  
Alok K. Pandey ◽  
Deepak Gurbani ◽  
Kainat Khan ◽  
Dhirendra Singh ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Preclinical Study ◽  
Nano Composite ◽  
In Vivo Efficacy ◽  
Bone Defect Repair ◽  
Defect Repair
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