20913 Neural activity involved in the control of cerebral blood flow in synaptic plasticity

Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal, simultaneous mapping of neural activity and hemodynamics is critical yet challenging to achieve. Here, we use a multimodal neural platform in a mouse model of stroke and realize long-term, spatially resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We observe a pronounced neurovascular dissociation that occurs immediately after small-scale strokes, becomes the most severe a few days after, lasts into chronic periods, and varies with the level of ischemia. Neuronal deficits extend spatiotemporally, whereas restoration of cerebral blood flow occurs sooner and reaches a higher relative value. Our findings reveal the neurovascular impact of ministrokes and inform the limitation of neuroimaging techniques that infer neural activity from hemodynamic responses.

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Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes

10.1101/2020.03.04.977322 ◽

2020 ◽

Cited By ~ 1

Author(s):

Fei He ◽

Colin Sullender ◽

Hanlin Zhu ◽

Michael R. Williamson ◽

Xue Li ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Neural Activity ◽

Brain Regions ◽

Small Scale ◽

Spatially Resolved ◽

Relative Value ◽

Brain States ◽

Neuroimaging Techniques

AbstractNeurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal, simultaneous mapping of neural activity and hemodynamics is critical yet challenging to achieve. Here, we employ a multimodal neural platform in a mouse model of stroke and realize long-term, spatially-resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We observe a pronounced neurovascular dissociation that occurs immediately after small-scale strokes, becomes the most severe a few days after, lasts into chronic periods, and varies with the level of ischemia. Neuronal deficits extend spatiotemporally whereas restoration of cerebral blood flow occurs sooner and reaches a higher relative value. Our findings reveal the neurovascular impact of mini-strokes and inform the limitation of neuroimaging techniques that infer neural activity from hemodynamic responses.

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Coupling of Changes in Cerebral Blood Flow with Neural Activity: What Must Initially Dip Must Come Back Up

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/01.wcb.0000103920.96801.12 ◽

2004 ◽

Vol 24 (1) ◽

pp. 1-6 ◽

Cited By ~ 46

Author(s):

Beau M. Ances

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Neuronal Activity ◽

Neural Activity ◽

Cerebral Blood Volume ◽

Imaging Modality ◽

Energy Depletion ◽

Flow Coupling ◽

Initial Dip ◽

Early Rise

Activation flow coupling, increases in neuronal activity leading to changes in cerebral blood flow (CBF), is the basis of many neuroimaging methods. An early rise in deoxygenation, the “initial dip,” occurs before changes in CBF and cerebral blood volume (CBV) and may provide a better spatial localizer of early neuronal activity compared with subsequent increases in CBF. Imaging modality, anesthetic, degree of oxygenation, and species can influence the magnitude of this initial dip. The observed initial dip may reflect a depletion of mitochondrial oxygen (O2) buffers caused by increased neuronal activity. Changes in CBF mediated by nitric oxide (NO) or other metabolites and not caused by a lack of O2 or energy depletion most likely lead to an increased delivery of capillary O2 in an attempt to maintain intracellular O2 buffers.

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