scholarly journals Which genetic mechanisms underlie the relationship between preschool vocabulary and later literacy skills?

2021 ◽  
Keyword(s):  
Vocabulary Acquisition ◽  
Genetic Factors ◽  
Literacy Skills ◽  
Language And Literacy ◽  
Genetic Mechanisms ◽  
The Relationship ◽  
Genetic Amplification

Preschool vocabulary acquisition is associated with later language and literacy skills. Genetic factors might partially explain this link, but the precise mechanisms are unclear. Thus far, twin-based studies have implicated mechanisms involving genetic amplification or genetic innovation.

scholarly journals The amplification of genetic factors for early vocabulary during children’s language and literacy development

2019 ◽  
Author(s):  
Ellen Verhoef ◽  
Chin Yang Shapland ◽  
Simon E. Fisher ◽  
Philip S. Dale ◽  
Beate St Pourcain
Keyword(s):  
Cognitive Skills ◽  
Structural Equation ◽  
Genetic Factors ◽  
Structural Equation Models ◽  
Receptive Language ◽  
Literacy Skills ◽  
Receptive Vocabulary ◽  
Genetic Influences ◽  
Childhood And Adolescence ◽  
Language And Literacy

AbstractThe heritability of language and literacy skills increases during development. The underlying mechanisms are little understood, and may involve (i) the amplification of early genetic influences and/or (ii) the emergence of novel genetic factors (innovation). Here, we use multivariate structural equation models to quantify these processes, as captured by genome-wide genetic markers. Studying expressive and receptive vocabulary at 38 months and subsequent language, literacy and cognitive skills (7-13 years) in unrelated children (ALSPAC: N≤6,092), we found little support for genetic innovation during mid-childhood and adolescence. Instead, genetic factors for early vocabulary, especially those unique to receptive skills, were amplified. Explaining as little as 3.9%(SE=1.8%) variation in early language, the same genetic influences accounted for 25.7%(SE=6.4%) to 45.1%(SE=7.6%) variation in verbal intelligence and literacy skills, but also performance intelligence, capturing the majority of SNP-heritability (≤99%). This suggests that complex verbal and non-verbal cognitive skills originate developmentaly in early receptive language.

From implicit to explicit language knowledge in intervention: Introduction to the Special Issue on intervention and metalanguage

2009 ◽  
Vol 29 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Dorit Ravid ◽  
Anat Hora
Keyword(s):  
Intervention Studies ◽  
Language Instruction ◽  
Literacy Skills ◽  
Metalinguistic Awareness ◽  
Language And Literacy ◽  
Special Issue ◽  
Language Knowledge ◽  
Developmental Psycholinguistics ◽  
The Relationship

The Special Issue is themed on intervention programs which set educational and clinical goals and use explicit language instruction to achieve them. This introduction to the Special Issue explores the non-obvious relationship between intervention, metalinguistics and the study of developmental psycholinguistics. Intervention is typically designed to remedy and accelerate processes that are assumed to be naturally occurring under optimal circumstances. Beyond employing intervention to test hypotheses in developmental cognitive science, most intervention studies are explicitly constructed to improve impaired or non-optimal language skills. The introduction reviews the two major themes of this issue: the problematic yet uniquely efficacious role of intervention studies in gauging the variables that can be modified to improve language and literacy skills; and the origins and nature of metalinguistic awareness in development. The five papers appearing in this Special Issue each highlight a different facet of the relationship between intervention and metalanguage.

scholarly journals Oral Language Skills and Literacy Skills of Malay Children with Dyslexia

2021 ◽  
Author(s):  
Rogayah A. Razak ◽  
Loke Xing Lin ◽  
Mohd Azmarul A. Aziz
Keyword(s):  
Oral Language ◽  
Pearson Correlation ◽  
Literacy Skills ◽  
Control Group ◽  
Language And Literacy ◽  
Local Data ◽  
Narrative Skills ◽  
Language Difficulties ◽  
Oral Language Skills ◽  
The Relationship

Dyslexia can involve among others, difficulties in spoken language. However, there is limited local data on oral language (narrative skills) and literacy skills in children with dyslexia. The relationship between language and literacy is well documented although they involve complicated and non-straightforward processes. There is also evidence suggesting a link between language difficulties with subsequent literacy difficulties. Thus, this study aims to identify and describe the language and literacy skills of Malay children with dyslexia, and to discuss the possible relationships between them. Subjects were six children with dyslexia in the Klang Valley, Malaysia aged 8:0 to 9:11 (mean age, 8:10) who were compared to an age-matched control group (n = 10). The battery of tests administrated was phonological awareness test, language task, narrative, and literacy tasks. Our findings showed that children with dyslexia had generally weaker language and literacy skills than the control group. There were significant differences (p < .05) in grammar understanding, sentence repetition, and reading and spelling at both word and paragraph levels. Pearson correlation between language and literacy was shown to be positive and strong, r = .887, p < .05. The qualitative discussion of the data is presented. Findings from this study would provide useful information to teachers and speech-language therapists in their teaching or planning of appropriate clinical evaluation and management of children with dyslexia.

Assessing Language and Literacy Skills of School-Aged Children

2008 ◽  
Vol 9 (2) ◽  
pp. 66-70
Author(s):  
Jennifer Walz Garrett
Keyword(s):  
Literacy Skills ◽  
Assessment Tools ◽  
Treatment Goals ◽  
Miscue Analysis ◽  
Language And Literacy ◽  
Speech Language Pathologists ◽  
School Aged Children ◽  
School Based ◽  
Assessment Procedures ◽  
Tools And Methods

Abstract School-based speech-language pathologists assess students to establish eligibility, collect baselines for treatment goals, determine progress during intervention and verify generalization of skills. Selecting appropriate assessment tools and methods can be challenging due to time constraints, agency regulations, and availability of tests. This article will describe legal considerations, types of assessments, and the factors involved with the selection and use of various assessment procedures and tools. In addition, speech-language pathologists will learn to calculate words correct per minute (WCPM) and perform miscue analysis, which can provide additional language and literacy information about a child's educational needs.

Молекулярная биология менингиом головного мозга

2017 ◽  
pp. 82-91
Author(s):  
В.А. Бывальцев ◽  
И.А. Степанов ◽  
Е.Г. Белых ◽  
А.И. Яруллина
Keyword(s):  
Gene Therapy ◽  
Proton Therapy ◽  
Genetic Factors ◽  
Intracranial Tumor ◽  
Molecular Profile ◽  
Genetic Changes ◽  
Treatment Techniques ◽  
Downstream Effects ◽  
Si Rna ◽  
The Relationship

Цель обзора - анализ современных данных литературы о нарушении внутриклеточных сигнальных путей, играющих ведущую роль в развитии менингиом, генетических и молекулярных профилях данной группы опухолей. К настоящему времени изучено множество аберрантных сигнальных внутриклеточных путей, которые играют важнейшую роль в развитии менингиом головного мозга. Четкое понимание поврежденных внутриклеточных каскадов поможет изучить влияние генетических мутаций и их эффектов на менингиомогенез. Подробное исследование генетического и молекулярного профиля менингиом позволит сделать первый уверенный шаг в разработке более эффективных методов лечения данной группы интракраниальных опухолей. Хромосомы 1, 10, 14, 22 и связанные с ними генные мутации ответственны за рост и прогрессию менингиом. Предполагается, что только через понимание данных генетических повреждений будут реализованы новейшие эффективные методы лечения. Будущая терапия будет включать в себя комбинации таргетных молекулярных агентов, в том числе генную терапию, малые интерферирующие РНК, протонную терапию и другие методы воздействия, как результат дальнейшего изучения генетических и биологических изменений, характерных для менингеальных опухолей. Meningiomas are by far the most common tumors arising from the meninges. A myriad of aberrant signaling pathways involved with meningioma tumorigenesis, have been discovered. Understanding these disrupted pathways will aid in deciphering the relationship between various genetic changes and their downstream effects on meningioma pathogenesis. An understanding of the genetic and molecular profile of meningioma would provide a valuable first step towards developing more effective treatments for this intracranial tumor. Chromosomes 1, 10, 14, 22, their associated genes, have been linked to meningioma proliferation and progression. It is presumed that through an understanding of these genetic factors, more educated meningioma treatment techniques can be implemented. Future therapies will include combinations of targeted molecular agents including gene therapy, si-RNA mediation, proton therapy, and other approaches as a result of continued progress in the understanding of genetic and biological changes associated with meningiomas.

Invited Review: Pharmacogenetics of estrogen replacement therapy

2001 ◽  
Vol 91 (6) ◽  
pp. 2776-2784 ◽  
Author(s):  
David M. Herrington ◽  
Karen Potvin Klein
Keyword(s):  
Estrogen Replacement Therapy ◽  
Genetic Factors ◽  
Estrogen Receptor Α ◽  
Estrogen Replacement ◽  
Risk Gene ◽  
Thrombosis Risk ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic ◽  
Relationship Of ◽  
The Relationship

There are a number of genetic factors that likely modulate both the beneficial and adverse effects of estrogen. An important domain of consideration is the relationship of estrogen and thrombosis risk. Gene polymorphisms among the key elements of the coagulation and fibrinolytic cascade appear to influence the effects of estrogen on risk for venous thromboembolic events and possibly arterial thrombosis as well. Emerging data also suggest that allelic variants in the estrogen receptor-α may modulate estrogen's effects, especially with respect to bone and lipid metabolism.

scholarly journals Role of the relationship between dyslipidemia and genetic factors in the development of atherosclerosis

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P708-P708
Author(s):  
S. Hata ◽  
M. Nakazato ◽  
T. Sekita ◽  
T. Maeda ◽  
T. Kanda
Keyword(s):  
Genetic Factors ◽  
The Relationship

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

2004 ◽  
Vol 10 (3) ◽  
pp. 266-271 ◽  
Author(s):  
B Zakrzewska-Pniewska ◽  
M Styczynska ◽  
A Podlecka ◽  
R Samocka ◽  
B Peplonska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Apolipoprotein E ◽  
Brain Atrophy ◽  
Genetic Factors ◽  
Clinical Course ◽  
Progression Rate ◽  
Disease Course ◽  
Familial Cases ◽  
Sporadic Cases ◽  
The Relationship

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

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