scholarly journals Peri-Operative Stress-Related Cardiomyopathy Following Paediatric Liver Transplant– A Case Series

2020 ◽  
Vol 6 (3) ◽  
Keyword(s):  
Heart Failure ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Clinical Outcomes ◽  
Case Series ◽  
Perioperative Period ◽  
Adverse Outcomes ◽  
Pediatric Liver Transplantation ◽  
Keywords Liver Transplantation ◽  
Keywords Liver

Perioperative stress-related cardiomyopathy has been extensively described in adults undergoing liver transplantation to be associated with adverse outcomes. Reports of stress-related cardiomyopathy among children is scarce and is usually associated with better clinical outcomes compared to adults. We describe 3 instances of pediatric liver transplantation who developed stress-related cardiomyopathy during the perioperative period and had adverse clinical outcomes. Keywords: Liver Transplantation; Stress-related cardiomyopathy; Heart failure.

scholarly journals HIV and Liver transplantation: The British Columbia Experience, 2004 to 2013

2014 ◽  
Vol 25 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Clara Tan-Tam ◽  
Pamela Liao ◽  
Julio S Montaner ◽  
Mark W Hull ◽  
Charles H Scudamore ◽  
...  
Keyword(s):  
British Columbia ◽  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Liver Transplant ◽  
Clinical Outcomes ◽  
Disease Status ◽  
Transplant Program ◽  
End Stage

BACKGROUND: The demand for definitive management of end-stage organ disease in HIV-infected Canadians is growing. Until recently, despite international evidence of good clinical outcomes, HIV-infected Canadians with end-stage liver disease were ineligible for transplantation, except in British Columbia (BC), where the liver transplant program of BC Transplant has accepted these patients for referral, assessment, listing and provision of liver allograft. There is a need to evaluate the experience in BC to determine the issues surrounding liver transplantation in HIV-infected patients.METHODS: The present study was a chart review of 28 HIV-infected patients who were referred to BC Transplant for liver transplantation between 2004 and 2013. Data regarding HIV and liver disease status, initial transplant assessment and clinical outcomes were collected.RESULTS: Most patients were BC residents and were assessed by the multidisciplinary team at the BC clinic. The majority had undetectable HIV viral loads, were receiving antiretroviral treatments and were infected with hepatitis C virus (n=16). The most common comorbidities were anxiety and mood disorders (n=4), and hemophilia (n=4). Of the patients eligible for transplantation, four were transplanted for autoimmune hepatitis (5.67 years post-transplant), nonalcoholic steatohepatitis (2.33 years), hepatitis C virus (2.25 years) and hepatitis B-delta virus coinfection (recent transplant). One patient died from acute renal failure while waiting for transplantation. Ten patients died during preassessment and 10 were unsuitable transplant candidates. The most common reason for unsuitability was stable disease not requiring transplantation (n=4).CONCLUSIONS: To date, interdisciplinary care and careful selection of patients have resulted in successful outcomes including the longest living HIV-infected post-liver transplant recipient in Canada.

Clinical Outcomes and Complications of Peroneal Tendon Sheath Ultrasound-Guided Corticosteroid Injection

2019 ◽  
Vol 40 (8) ◽  
pp. 888-894 ◽  
Author(s):  
Brianna R. Fram ◽  
Ryan Rogero ◽  
Daniel Fuchs ◽  
Rachel J. Shakked ◽  
Steven M. Raikin ◽  
...  
Keyword(s):  
Pain Relief ◽  
Clinical Outcomes ◽  
Corticosteroid Injection ◽  
Case Series ◽  
Tendon Sheath ◽  
Adverse Outcomes ◽  
Peroneal Tendon ◽  
Foot And Ankle ◽  
Duration Of Symptoms ◽  
Peroneal Tendons

Background: The treatment of symptomatic peroneal tendinopathy and tears traditionally begins with nonsteroidal anti-inflammatory drugs, activity modification, physical therapy, and immobilization, with surgery typically reserved for those failing nonoperative treatment. Ultrasound-(US)-guided peroneal tendon sheath (PTS) corticosteroid injection is an additional nonoperative modality, but limited data exist on its safety and efficacy. The purpose of this study was to assess clinical outcomes following US-guided PTS corticosteroid injection for chronic tendinopathy or tears. Methods: We retrospectively identified patients who had undergone US-guided PTS corticosteroid injection for pain due to peroneal tendinopathy, tears, or subluxation at our institution from 2012 to 2018. Underlying diagnosis was based on clinical examination, magnetic resonance imaging (MRI) results, and/or intraoperative findings, when available. Medical record data were supplemented by e-mail or telephone follow-up. Collected information included patient age, sex, body mass index (BMI), smoking status, workers’ compensation status, prior surgeries about the foot and ankle, duration of symptoms prior to injection, perceived improvement in pain following injection and its duration, number of injections, progression to surgery, and any adverse outcomes of injection. We identified 96 patients (109 injections). Thirty-seven (38.5%) had previous foot and ankle surgery, with 17 (17.7%) having surgery specifically on the peroneal tendons. Results: Twenty-four of 96 (25%) progressed to have surgery on their peroneal tendons following injection. Following injection, 38/87 (43.7%) of patients reported 0-1 weeks of pain relief, 11/87 (12.6%) 2-6 weeks, 6/87 (6.9%) 7-12 weeks, and 32/87 (36.8%) greater than 12 weeks. Preinjection duration of symptoms was associated with postinjection duration of pain relief ( P=.036). There were 2 reported complications (1.8%): 1 case of self-limited sural nerve irritation and 1 of peroneus longus tear progression. Conclusion: Our study demonstrates US-guided PTS corticosteroid injection was safe and relatively effective in patients with symptomatic peroneal tendon tears or tendinopathy, including those who had undergone prior surgery, and may be considered in a comprehensive protocol of nonoperative management. Level of Evidence: Level IV, case series.

Liver Transplantation in Patients With Cardiac Disease

2017 ◽  
Vol 22 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Christopher L. Wray
Keyword(s):  
Cardiovascular Disease ◽  
Liver Transplantation ◽  
Perioperative Period ◽  
Cardiovascular Complications ◽  
Adverse Outcomes ◽  
Treatment Modalities ◽  
Cardiac Complications ◽  
Major Step ◽  
Cardiac Evaluation ◽  
The Impact

Liver transplantation (LT) is a unique surgical procedure that has major hemodynamic and cardiovascular implications. Recently, there has been significant interest focused on cardiovascular issues that affect LT patients in all phases of the perioperative period. The preoperative cardiac evaluation is a major step in the selection of LT candidates. LT candidates are aging in concordance with the general population; cardiovascular disease and their risk factors are highly associated with older age. Underlying cardiovascular disease has the potential to affect outcomes in LT patients and has a major impact on candidate selection. The prolonged hemodynamic and metabolic instability during LT may contribute to adverse outcomes, especially in patients with underlying cardiovascular disease. Cardiovascular events are not unusual during LT; transplant anesthesiologists must be prepared for these events. Advanced cardiovascular monitoring techniques and treatment modalities are now routinely used during LT. Postoperative cardiovascular complications are common in both the early and late posttransplant periods. The impact of cardiac complications on posttransplant mortality is well recognized. Emerging knowledge regarding cardiovascular disease in LT patients and its impact on posttransplant outcomes will have an important role in guiding the future perioperative management of LT patients.

scholarly journals Early lung complications in the post-transplant period of the liver

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Victor Pirvu ◽  
◽  
Angela Peltec ◽  
Adrian Hotineanu ◽  
Natalia Taran ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Clinical Outcomes ◽  
Surgical Techniques ◽  
Clinical Manifestations ◽  
Perioperative Period ◽  
Respiratory Complications ◽  
Respiratory Disorders ◽  
Post Transplant

This subject underlines the most important perioperative factors that predispose to early post-liver transplant respiratory complications. Despite advances in surgical techniques and anesthesiological management the lung may still suffer throughout the perioperative period from various types of injury, with different ensuing ventilatory impairments, and different clinical outcomes. The incidence, etiology, pathophysiological features, clinical manifestations, preventing measures, and outcomes of post-operative respiratory disorders in this setting are also reported.

scholarly journals Long Term Clinical Outcomes in Patients with Moderate Aortic Stenosis

2020 ◽  
Vol 23 (3) ◽  
pp. E358-E365
Author(s):  
Han Joon Bae ◽  
Jongmin Hwang ◽  
Seongwook Han ◽  
Seung-Ho Hur ◽  
Jin-Wook Chung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Aortic Stenosis ◽  
Clinical Outcomes ◽  
Medical Records ◽  
Watchful Waiting ◽  
Adverse Outcomes ◽  
Functional Mitral Regurgitation

Background: While the surgical correction of moderate aortic stenosis (AS) can be deferred with a watchful waiting according to the present guideline, the clinical outcomes for moderate AS with comorbidity have not extensively been studied. We aimed to explore the factors that would contribute to the outcomes of moderate AS with at least five years of follow-up duration. Methods: Medical records review identified patients with moderate aortic valve (AV) stenosis from January 2008 and December 2012. Echocardiographic data were gathered, and the final 5-year clinical outcomes, defined as the composite of cardiovascular (CV) death, admission for heart failure (HF) aggravation, and AV replacement, were evaluated. Results: Among 148 patients (mean age, 69.3 years; mean AV area, 1.24 cm2), 79 had adverse outcomes (16 CV deaths, 32 AV replacements, and 31 HF cases), during a mean follow-up of 5.6 years. The event group showed worse dyspnea of NYHA III-IV and a higher frequency of diabetes mellitus (DM). They had a higher frequency of moderate or moderate-to-severe functional mitral regurgitation (MR) and smaller AV area. In the multivariate analysis, DM (HR 2.29, 95% CI 1.03-5.10), moderate or moderate-to-severe MR (HR 4.84, 95% CI 1.66-10.07), and NYHA III-IV (HR 3.84, 95% CI 1.72-8.56) independently were associated with adverse outcomes. Conclusions: The symptomatic patients with moderate AS had higher events than expected, and early intervention should be considered in case of concomitant MR and DM.

Surgical aspects of pediatric liver transplantation. Living donor liver transplant program in Hungary

2008 ◽  
Vol 149 (27) ◽  
pp. 1271-1275 ◽  
Author(s):  
László Kóbori ◽  
Zoltán Máthé ◽  
János Fazakas ◽  
Zsuzsanna Gerlei ◽  
Attila Doros ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Living Donor ◽  
Pediatric Liver Transplantation ◽  
Donor Liver ◽  
Transplant Program ◽  
Kaplan Meier ◽  
Living Donor Liver Transplant ◽  
Donor Liver Transplant ◽  
Surgical Aspects

A májátültetés jelenti a gyermekkori végstádiumú májbetegségek egyetlen kezelési módját. A split, majd az ezt követően kifejlesztett élő donoros májátültetés ma már rutinbeavatkozásnak számít, és a gyermekkori átültetések alapját jelentik. Az átlagos Kaplan–Meier-féle meghatározás szerinti 1, illetve 5 éves túlélés 80–90% feletti. A donormáj splittelése során két májbetegen segíthetünk. A bal oldali laterális szegmenteket általában gyermekeknek, a nagyobb jobb oldalt felnőtteknek ültetjük át. Természetesen többféle kombináció jön szóba attól függően, hogy élő donoros vagy split-, vagy redukált májátültetésről van szó. Az átültetéshez szükséges májszövet mennyisége a testsúly minimum 1%-át jelenti. A hazai több mint 340 májátültetés során 27 gyermek (14 parciális graft) májátültetéséről számolhatunk be, és elindult az élődonor-program is. Az alkalmazott technikák eredményeit és szövődményeit is figyelembe véve elmondható, hogy megfelelően szigorú kivizsgálási protokollok betartásával, a sebészi, aneszteziológiai és intenzív osztályos kezelés megfelelő szintű fejlesztésével a hazai átültetések eredményei nemzetközi szintre emelkedtek. Az utolsó 5 év átlagos túlélése 80% feletti volt.

Sign in / Sign up

Export Citation Format

Share Document