scholarly journals Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

2021 ◽  
Vol 7 (2) ◽  

Introduction: Fibrous dysplasia (FD) is a benign lesion characterized by replacement of normal bone with abnormal connective tissue. It occurs in monostotic or polyostotic forms, with a rare but proven potential for malignant transformation. Symptoms of acute pain, rapid swelling, or an enlarging mass should increase suspicion for possible sarcomatous change. Complete surgical resection is the mainstay of treatment, and chemotherapy is recommended to improve survival. Case Report: A 52-year-old male presented with a painful, enlarging mass on the right proximal thigh 2 years after undergoing plate fixation of the distal femur for a pathologic fracture secondary to monostotic FD. Diagnostic imaging revealed signs of recurrence, and core needle biopsy revealed aggressive features suggestive of malign ant transformation. Following surgical resection and chemotherapy, the outcome has been uneventful without evidence of recurrence or metastasis at 4-year post-operation. Conclusion: Malignant transformation in monostotic FD is rare. Symptom exacerbation should increase the suspicion for sarcomatous change and prompt the need for diagnostic imaging as well as histologic confirmation.

Author(s):  
Pratyush Shahi ◽  
Apoorv Sehgal ◽  
Aarushi Sudan

A 35-year-old female presented to us with anterior bowing of her right tibia. The deformity developed in her adolescence and subsequently had not progressed for nearly two decades. The patient had no functional limitation, her only concern being cosmesis. Radiological investigations suggested either fibrous dysplasia or adamantinoma. Biopsy showed fibrous stroma consisting of myxofibrous tissue and woven bone which was confirmatory of fibrous dysplasia. Keeping in mind that it was a dormant benign lesion not hindering with functionality of the limb, it was decided to keep the patient under observation with regular follow-up.


2018 ◽  
Vol 5 (3) ◽  
pp. 1137
Author(s):  
Sudha Yadav ◽  
Kamal Nain Rattan ◽  
Pawan Yadav ◽  
Sunil Gavhane

Scrotal lymphangiomas are hamartomata’s lymphatic malformations with no risk of malignant transformation, resulting due to inadequate drainage of lymph from sequestered lymph or lack of continuation between lymphatics and venous channels. Here we report a case of scrotal lymphangioma in a 1.5 years old child who presented with scrotal swelling and misdiagnosed as hydrocele. Child was managed successfully with surgical resection of the mass and doing well now.


2012 ◽  
Vol 2 (4) ◽  
pp. 335-337 ◽  
Author(s):  
S Gon ◽  
B Majumdar ◽  
A Bhattacharyya ◽  
RN Bhattacharya

Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.Journal of Pathology of Nepal (2012) Vol. 2, 335-337DOI: http://dx.doi.org/10.3126/jpn.v2i4.6891


2018 ◽  
Vol 7 (4) ◽  
pp. 1-5
Author(s):  
Przemysław Krawczyk ◽  
Daniel Majszyk ◽  
Antoni Bruzgielewicz ◽  
Kazimierz Niemczyk

Granular cell tumor is benign neoplasm rarely diagnosed among young children and adolescents. The tumor developed commonly within mucous membrane of upper airways, but precise etiology is not known. Treatment is based on surgical resection of tumor and intense follow up due to risk of recurrence and malignant transformation.


2021 ◽  
pp. 485-488
Author(s):  
Vijaya R Kamble ◽  
Shalini N Waghmare ◽  
Aditi V Rangari ◽  
Mangala Meti ◽  
Pritam Pohankar ◽  
...  

Fibrous dysplasia (FD) is a skeletal developmental anomaly, which is non-hereditary in origin and idiopathic in nature. It is a benign fibro-osseous disease that affects one or more bones. It usually affects unilaterally and is seen in the posterior region. Approximately 0.5% of untreated cases show the malignant transformation. We report the case of a 35-year-old female patient with FD involving the maxilla. The clinical diagnostic approach, different imaging modalities, and histological examination methods for definitive diagnosis have been elaborated.


2016 ◽  
Vol 21 (2) ◽  
pp. 115-118
Author(s):  
Shouvanik Satpathy ◽  
Goutam Mondal ◽  
Anup Kumar Bhowmick ◽  
Aniruddha Dam

Cervical vagal schwannomas are rare, slow growing tumours usually occur in patients between thirty and fifty years of age with no sex related predisposition. They are usually asymptomatic benign lesion and complete surgical resection with preservation of neural pathway, whenever possible is the treatment of choice.Bangladesh J Otorhinolaryngol; October 2015; 21(2): 115-118


2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Samantha Seitter ◽  
Zachary D. Goodman ◽  
Theodore M. Friedman ◽  
Timothy R. Shaver ◽  
George Younan

Introduction. Reactive lymphoid hyperplasia (RLH) is a rare and benign lesion found in organs of the gastrointestinal tract, skin, lung, orbit, and more rarely in the liver. Due to its similar appearance on imaging, it is hard to differentiate from primary liver malignancies. The following is a case report of a patient presenting with a suspicious liver lesion found to be RLH associated with primary biliary cirrhosis (PBC), after surgical resection. Presentation of Case. A 54-year-old woman presented with nonspecific abdominal pain, and her workup included axial imaging of the abdomen that showed a suspicious lesion in her liver. After an extensive workup, which included a percutaneous biopsy, failed to confirm a diagnosis, a laparoscopic surgical resection was recommended. Discussion. RLH is a rare condition of the liver, presenting in a suspicious fashion and raising concerns for a primary liver malignancy. RLH should be considered in the differential diagnosis of small hepatic lesions in middle-age females in the absence of any significant risk factors for hepatocellular carcinoma (HCC). RLH tends to be associated with PBC of the liver. Conclusion. RLH of the liver is a rare, hard to diagnose, benign lesion. When intrahepatic, it cannot be easily differentiated from primary liver tumors and frequently requires surgical resection for pathological diagnostic confirmation.


2014 ◽  
Vol 8 (1) ◽  
pp. 384-386 ◽  
Author(s):  
HIROSHI HATANO ◽  
TETSURO MORITA ◽  
TAKASHI ARIIZUMI ◽  
HIROYUKI KAWASHIMA ◽  
AKIRA OGOSE

2021 ◽  
pp. 014556132110565
Author(s):  
Dong Liu ◽  
Maocai Li ◽  
Lianqing Li ◽  
Lili Gong ◽  
Zuping Zhang

A pharyngeal recess cyst is a benign lesion, located at the nasopharyngeal recess with limited development. Pharyngeal recess cysts rarely occur. This case report describes a young male patient presenting with a foreign body sensation in the pharynx. Electronic nasopharyngoscope examination revealed a large nasopharyngeal cyst, whose root was located in the left pharyngeal recess. Complete surgical resection was performed, and the patient successfully recovered. Pharyngeal recess cysts are rare lesions that can be diagnosed based on imaging and endoscopy findings. It is treated surgically and has a favorable prognosis.


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