scholarly journals Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance

2012 ◽  
Vol 2 (4) ◽  
pp. 335-337 ◽  
Author(s):  
S Gon ◽  
B Majumdar ◽  
A Bhattacharyya ◽  
RN Bhattacharya
Keyword(s):  
Radiation Exposure ◽  
Fibrous Dysplasia ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Osteogenic Sarcoma ◽  
Extensive Search ◽  
Short Period ◽  
History Of ◽  
Lag Period ◽  
One Year

Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.Journal of Pathology of Nepal (2012) Vol. 2, 335-337DOI: http://dx.doi.org/10.3126/jpn.v2i4.6891

scholarly journals Case report of fibrous dysplasia in a pediatric patient: importance of adequate treatment to avoid malignization

2021 ◽  
Author(s):  
João Victor Bezerra Ramos ◽  
João Lucas Pordeus de Menezes ◽  
Louyse Jerônimo de Morais ◽  
Maurus Marques de Almeida Holanda
Keyword(s):  
Fibrous Dysplasia ◽  
Malignant Transformation ◽  
Adequate Treatment ◽  
Long Term Follow Up ◽  
History Of ◽  
Daily Headache ◽  
The Right ◽  
Temporal Bones

Background: Fibrous dysplasia is a congenital and benign bone tumor. There may be malignant transformation in some cases, with a mortality rate of 53.6%. Objectives and Methods: To describe a patient with fibrous dysplasia in childhood in the parietal and temporal bones, and to report the importance of surgical correction to prevent malignant transformation. The case was studied and came from a referral hospital – João Pesssoa, PB. Results: History of daily headache and bulging in the temporal and parietal regions on the right. Computed tomography revealed lesions in the aspect of “ground glass”. Surgery was performed with exposure of two lesions, with craniectomy, followed by cranioplasty. Such an approach should be recommended, since malignant transformation occurs in up to 1% of cases, but after radiotherapy this rate can reach 44% of cases, mainly osteosarcoma. In this case, the anatomopathological study revealed a diagnosis of fibrous dysplasia and the patient has been followed up for 20 years without recurrences, which are common in adolescence. Conclusions: It is important to make a differential diagnosis with malignant diseases, in addition to contraindicating radiotherapy to prevent malignant transformation; long-term follow-up is essential to avoid relapses and / or complications resulting from the disease.

scholarly journals Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Iqbal Multani ◽  
Snezana Popovic ◽  
Naveen Parasu ◽  
Michelle Ghert
Keyword(s):  
Fibrous Dysplasia ◽  
Malignant Transformation ◽  
Clinical Symptoms ◽  
Rare Condition ◽  
Close Monitoring ◽  
Case Presentation ◽  
Mazabraud’S Syndrome ◽  
Asymptomatic Patients ◽  
One Year ◽  
Radiographic Changes

Introduction. Mazabraud’s Syndrome is a rare condition that is defined by the presence of fibrous dysplasia lesions in the bone and intramuscular myxomas in the soft tissue. Malignant transformation, in the setting of Mazabraud’s Syndrome, of the fibrous dysplasia lesions into a sarcomatous neoplasm occurs in less than 1% of cases—with only six previously reported cases. Case Presentation. Here, we present a 62-year-old Caucasian female who developed an osteosarcoma in a fibrous dysplasia lesion of the proximal femur in the background of Mazabraud’s Syndrome. The patient was treated with wide excision and endoprosthetic reconstruction. She declined adjuvant chemotherapy. She is alive without evidence of disease one-year postoperatively. Conclusion. Patients with Mazabraud’s Syndrome remain at low risk for malignant transformation. However, close monitoring of asymptomatic patients with this condition for radiographic changes in their lesions and/or clinical symptoms is recommended.

scholarly journals Malignant Transformation of Monostotic Fibrous Dysplasia after Surgery: A Case Report

2021 ◽  
Vol 7 (2) ◽  
Keyword(s):  
Case Report ◽  
Diagnostic Imaging ◽  
Fibrous Dysplasia ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Plate Fixation ◽  
Benign Lesion ◽  
Pathologic Fracture ◽  
Sarcomatous Change ◽  
Post Operation

Introduction: Fibrous dysplasia (FD) is a benign lesion characterized by replacement of normal bone with abnormal connective tissue. It occurs in monostotic or polyostotic forms, with a rare but proven potential for malignant transformation. Symptoms of acute pain, rapid swelling, or an enlarging mass should increase suspicion for possible sarcomatous change. Complete surgical resection is the mainstay of treatment, and chemotherapy is recommended to improve survival. Case Report: A 52-year-old male presented with a painful, enlarging mass on the right proximal thigh 2 years after undergoing plate fixation of the distal femur for a pathologic fracture secondary to monostotic FD. Diagnostic imaging revealed signs of recurrence, and core needle biopsy revealed aggressive features suggestive of malign ant transformation. Following surgical resection and chemotherapy, the outcome has been uneventful without evidence of recurrence or metastasis at 4-year post-operation. Conclusion: Malignant transformation in monostotic FD is rare. Symptom exacerbation should increase the suspicion for sarcomatous change and prompt the need for diagnostic imaging as well as histologic confirmation.

Challenges of the Illiberal Democracy in Hungary. Some Aspects to the 2018 Elections

2018 ◽  
Vol 6 (2) ◽  
pp. 70-90
Author(s):  
Schmidt Andrea
Keyword(s):  
Eastern European ◽  
Political Transformation ◽  
The European Union ◽  
Illiberal Democracy ◽  
Short Period ◽  
History Of ◽  
The Government ◽  
Eastern European Countries ◽  
One Year ◽  
Annus Mirabilis

Abstract Political transformation reached Hungary in parallel with other Central and Eastern European countries at the turn of the 1980s and 1990s. The core of the events, the year of 1989, the so called “annus mirabilis” when, within one year almost the entire Central and Eastern European region stepped onto the path of changes. The actors adopted Western patterns within a short period, institutions of new political systems were established, and a new political power verified and consolidated its legitimacy by free elections. As a final proof of transformation, most of former socialist bloc member states joined both the NATO and the European Union. Hungary had the chance to enter in the 21st century under radically changed and much more favourable conditions than it ever had before. This smooth transformation interrupted by political and economic crisis that finally led to the victory of the opposition that managed to repeat the next elections and implemented the Programme of National Cooperation. The aim of the paper is to analyse why the adoption of the new system enjoys wide support from different social groups and how the old fixations and obsessions persisted in society. This paper also gives a brief explanation about the nature of illiberal democracy in a wider scope and link it with the history of the Hungarian democracy, the (dis) functioning institutions, and confirms the argumentation with some statistical data explaining the correlation between the support of the government and the living standards. It investigates, if the Hungarian illiberal democratic regime interpreted as consequence of the troublesome system changes or if it is rooted in the distorted political system.

scholarly journals TEKA: A Transnational Network of Esperanto-Speaking Physicians

2021 ◽  
Vol 10 (2) ◽  
pp. 243-266
Author(s):  
Marcel Koschek
Keyword(s):  
World War I ◽  
Medical Association ◽  
Red Cross ◽  
World War ◽  
Short Period ◽  
Transnational Network ◽  
History Of ◽  
One Year ◽  
Circulation Of Knowledge

The Tutmonda Esperanta Kuracista Asocio (Worldwide Esperanto Medical Association, TEKA) was founded in 1908 at the Fourth International Esperanto Congress in Dresden and was the international medical association of the Esperanto movement. The aim was to “facilitate practical relations between Esperanto-speaking doctors of all countries.” The interest within the Esperanto movement was immense: after one year, TEKA had more than 400 members all over the world with a focus on Europe; one year later, there were more than 600 members with official representatives in about 100 cities. In Europe, a medical press in Esperanto had already been established. The approach of these journals was both simple and brilliant: the doctors presented the latest medical findings from their home countries in a peer review system and critically examined the articles in their vernacular. This made each issue a compendium of the most important and pioneering findings of national research. The numerous experts also had many other connections with, for example, the Red Cross and similar organizations. Thus, after a short period of time, TEKA brought together the expertise of countless physicians. This paper examines TEKA as a transnational network of experts before World War I. The history of the association and the role of Medicine within the Esperanto movement are briefly discussed. The focus is then on the various association journals and the circulation of knowledge. Finally, the essay offers a look at TEKA’s cooperative endeavors with the Red Cross. It works from a transnational perspective and takes a close view of the actors and their personal backgrounds at appropriate points. Furthermore, lists of members and journal subscribers are provided in map form to make the global spread of the movement within medicine visible.

Treatment of varicose tributaries with sclerotherapy with polidocanol 0.5 % foam

VASA ◽  
2010 ◽  
Vol 39 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Reich-Schupke ◽  
Weyer ◽  
Altmeyer ◽  
Stücker
Keyword(s):  
Scientific Evidence ◽  
Daily Practice ◽  
Severe Adverse Effect ◽  
Safe Procedure ◽  
Efficacy And Safety ◽  
Foam Sclerotherapy ◽  
History Of ◽  
One Year ◽  
Additional Therapy

Background: Although foam sclerotherapy of varicose tributaries is common in daily practice, scientific evidence for the optimal sclerosant-concentration and session-frequency is still low. This study aimed to increase the knowledge on foam sclerotherapy of varicose tributaries and to evaluate the efficacy and safety of foam sclerotherapy with 0.5 % polidocanol in tributaries with 3-6 mm in diameter. Patients and methods: Analysis of 110 legs in 76 patients. Injections were given every second or third day. A maximum of 1 injection / leg and a volume of 2ml / injection were administered per session. Controls were performed approximately 6 months and 12 months after the start of therapy. Results: 110 legs (CEAP C2-C4) were followed up for a period of 14.2 ± 4.2 months. Reflux was eliminated after 3.4 ± 2.7 injections per leg. Insufficient tributaries were detected in 23.2 % after 6.2 ± 0.9 months and in 48.2 % after 14.2 ± 4.2 months, respectively. Only 30.9 % (34 / 110) of the legs required additional therapy. In 6.4 % vein surgery was performed, in 24.5 % similar sclerotherapy was repeated. Significantly fewer sclerotherapy-sessions were required compared to the initial treatment (mean: 2.3 ± 1.4, p = 0.0054). During the whole study period thrombophlebitis (8.2 %), hyperpigmentation (14.5 %), induration in the treated region (9.1 %), pain in the treated leg (7.3 %) and migraine (0.9 %) occurred. One patient with a history of thrombosis developed thrombosis of a muscle vein (0.9 %). After one year there were just hyperpigmentation (8.2 %) and induration (1.8 %) left. No severe adverse effect occurred. Conclusions: Foam sclerotherapy with injections of 0.5 % polidocanol every 2nd or 3rd day, is a safe procedure for varicose tributaries. The evaluation of efficacy is difficult, as it can hardly be said whether the detected tributaries in the controls are recurrent veins or have recently developed in the follow-up period. The low number of retreated legs indicates a high efficacy and satisfaction of the patients.

Newton and the Origin of Civilization

2012 ◽  
Author(s):  
Jed Z. Buchwald ◽  
Mordechai Feingold
Keyword(s):  
Good Reason ◽  
History Of Mathematics ◽  
Primary Sources ◽  
Ancient History ◽  
Isaac Newton ◽  
History Of ◽  
Ancient Civilizations ◽  
And Mathematics ◽  
One Year ◽  
Radical Ideas

Isaac Newton’s Chronology of Ancient Kingdoms Amended, published in 1728, one year after the great man’s death, unleashed a storm of controversy. And for good reason. The book presents a drastically revised timeline for ancient civilizations, contracting Greek history by five hundred years and Egypt’s by a millennium. This book tells the story of how one of the most celebrated figures in the history of mathematics, optics, and mechanics came to apply his unique ways of thinking to problems of history, theology, and mythology, and of how his radical ideas produced an uproar that reverberated in Europe’s learned circles throughout the eighteenth century and beyond. The book reveals the manner in which Newton strove for nearly half a century to rectify universal history by reading ancient texts through the lens of astronomy, and to create a tight theoretical system for interpreting the evolution of civilization on the basis of population dynamics. It was during Newton’s earliest years at Cambridge that he developed the core of his singular method for generating and working with trustworthy knowledge, which he applied to his study of the past with the same rigor he brought to his work in physics and mathematics. Drawing extensively on Newton’s unpublished papers and a host of other primary sources, the book reconciles Isaac Newton the rational scientist with Newton the natural philosopher, alchemist, theologian, and chronologist of ancient history.

Stepping up detection, response, preparedness and readiness measures for “COVID-19”- A Pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1042-1047
Author(s):  
Khushbu Balsara ◽  
Deepankar Shukla
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Clinical History ◽  
Frontline Workers ◽  
Diagnostic Assays ◽  
Care Workers ◽  
Short Period ◽  
History Of ◽  
Detection Response ◽  
Care Worker

In a very short period of time, “COVID-19” has seized the consciousness globally by making remarkable changes in our day to day living and has superintended as a public health emergency globally. It has high radar of transmission, affecting an individual at work to frontline workers. The measures and planning for a response plays a key role from drawing up an emergency committee and this follows an equation which broadly deals with epidemiological to clinical history of the patient, management steps from isolation, screening, diagnostic assays for identification and treatment. The application of an organized plan with secure structure aids in better performance, increases efficacy of management and saves time. Also saves time for a health care worker to g through routine levels of channels of administration if already a familiar way of operation is known for such situations. Thus, planning and developing a ‘blueprint of approach’ towards management of patient while facing such situation is a must. This review provides an insight to the measures for detection, response and preparedness of the hospital and health care workers should largely be inclusive of; also highlights the measures to be taken at every step after coming in contact with a positive case of “COVID-19”.

“The last chord of the Silver Age”: science and culture in Crimea in 1920

2020 ◽  
Vol 2020 (10-4) ◽  
pp. 4-14
Author(s):  
Vladimir Kalinovsky ◽  
Alexander Puchenkov
Keyword(s):  
Civil War ◽  
The South ◽  
Silver Age ◽  
Russian Culture ◽  
Short Period ◽  
The Crimea ◽  
Science And Culture ◽  
History Of ◽  
Russian Intelligentsia

This article is devoted to the development of science and culture in the short period of the Wrangel Crimea - 1920. At this time, the brightest figures of Russian culture of that time worked on the territory of the small Peninsula: O. E. Mandelstam, M. A. Voloshin, B.D. Grekov, G.V. Vernadsky, V.I. Vernadsky and others. The article provides an overview of the life and activities of the Russian intelligentsia in 1920 in the Crimea, based on materials of periodicals as the most important source for studying the history of the Civil war in the South of Russia whose value is to be fully evaluated.

Sign in / Sign up

Export Citation Format

Share Document