Safety of augmentation cystoplasty in patients with bladder abnormalities undergoing renal transplantation: a systematic review

BACKGROUND Augmentation cystoplasty (AC) has been recently proposed to improve a bladder condition before or after a renal transplantation for an optimal allograft function. Until now, AC in adults with end-stage renal disease (ESRD) is uncommon and rarely practiced. This study aimed to investigate the safety of AC in patients with bladder abnormalities who required renal transplantation. METHODS Studies of patients with ESRD and abnormal bladder who underwent AC were searched in ProQuest, PubMed, EBSCO, and Cochrane Library online databases. Only studies published in English from January 1985 to May 2020 were included. The keywords used were renal transplantation, bladder dysfunction, cystoplasty, and their synonyms. Data were extracted by two independent authors who selected, screened, and assessed the articles’ eligibility and quality. The outcomes were graft survival rate and complications of AC. RESULTS A total of 19 articles were included. AC improved an intravesical pressure, a bladder capacity, and a compliance in patients with ESRD and bladder abnormalities, allowing patients to undergo the renal transplantation. Even though AC in patients with renal transplantation resulted in a significantly higher urinary tract infection rate than patients who underwent renal transplantation only, performing AC after renal transplantation was considered safe. CONCLUSIONS AC was considered safe for patients with bladder abnormalities who underwent renal transplantation.

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Factors Predicting Renal Function Outcome after Augmentation Cystoplasty

International Journal of Nephrology ◽

10.1155/2017/3929352 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Shahbaz Mehmood ◽

Raouf Seyam ◽

Sadia Firdous ◽

Waleed Mohammad Altaweel

Keyword(s):

Renal Function ◽

Bladder Capacity ◽

Posterior Urethral Valve ◽

Augmentation Cystoplasty ◽

Significant Deterioration ◽

Renal Deterioration ◽

Bladder Compliance ◽

Urethral Valve ◽

Stage Renal Disease ◽

End Stage

We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was7.0±2.6years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median114±53.6to342.1±68.3 ml (p=.0001),68.5±19.9to28.2±6.9 cm H2O (p=.0001), and3.0±2.1to12.8±3.9(p=.0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR135±81.98to142.82±94.4 ml/min/1.73 m2(p=.160). Significant deterioration was found in 7 (24%) patients from median eGFR68.25±42to36.57±35.33(p=.001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87,p=0.0155) and noncompliance (OR 30.78,p=0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency.

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Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis

International Journal of Impotence Research ◽

10.1038/s41443-021-00419-6 ◽

2021 ◽

Author(s):

Irham Arif Rahman ◽

Nur Rasyid ◽

Ponco Birowo ◽

Widi Atmoko

Keyword(s):

Systematic Review ◽

Erectile Dysfunction ◽

Kidney Transplantation ◽

Renal Transplantation ◽

End Stage Renal Disease ◽

Erectile Function ◽

Meta Analysis ◽

Post Transplantation ◽

Stage Renal Disease ◽

End Stage

AbstractErectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function.

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Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073471 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3471

Author(s):

Hyeon-Ju Lee ◽

Youn-Jung Son

Keyword(s):

Systematic Review ◽

Renal Disease ◽

End Stage Renal Disease ◽

Associated Factors ◽

Meta Analysis ◽

Screening Tools ◽

Cochrane Library ◽

Stage Renal Disease ◽

End Stage ◽

Esrd Patients

Hemodialysis is the most common type of treatment for end-stage renal disease (ESRD). Frailty is associated with poor outcomes such as higher mortality. ESRD patients have a higher prevalence of frailty. This systematic review and meta-analysis aimed to identify the prevalence and associated factors of frailty and examine whether it is a predictor of mortality among ESRD patients undergoing hemodialysis. Five electronic databases including PubMed, Embase, CINAHL, Web of Science, and Cochrane Library were searched for relevant studies up to 30 November 2020. A total of 752 articles were found, and seven studies with 2604 participants in total were included in the final analysis. The pooled prevalence of frailty in patients with ESRD undergoing hemodialysis was 46% (95% Confidence interval (CI) 34.2−58.3%). Advanced age, female sex, and the presence of diabetes mellitus increased the risk of frailty in ESRD patients undergoing hemodialysis. Our main finding showed that patients with frailty had a greater risk of all-cause mortality compared with those without (hazard ratio (HR): 2.02, 95% CI: 1.65−2.48). To improve ESRD patient outcomes, healthcare professionals need to assess the frailty of older ESRD patients, particularly by considering gender and comorbidities. Comprehensive frailty screening tools for ESRD patients on hemodialysis need to be developed.

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Peritoneal Dialysis: A Scoping Review of Strategies to Maximize pd Utilization

Peritoneal Dialysis International ◽

10.3747/pdi.2016.00057 ◽

2017 ◽

Vol 37 (2) ◽

pp. 159-164 ◽

Cited By ~ 9

Author(s):

Bikaramjit S. Mann ◽

Braden J. Manns ◽

Lianne Barnieh ◽

Matthew J. Oliver ◽

Daniel Devoe ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Scoping Review ◽

Controlled Trials ◽

Effective Strategies ◽

Online Databases ◽

Unpublished Studies ◽

Cochrane Database ◽

Stage Renal Disease ◽

End Stage ◽

Effective Use

The percentage of end-stage renal disease (ESRD) patients treated with peritoneal dialysis (PD) has declined in many countries since the mid-1990s. Barriers to PD have been reviewed extensively in the literature, but evidence about strategies to address these barriers and maximize the safe and effective use of PD is lacking. We therefore decided to conduct a scoping review identifying strategies to maximize PD use in adults with ESRD. Our search strategy included the following online databases: MEDLINE (OVID), EMBASE, PubMed, Cochrane Controlled Trials Register, Current Controlled Trials, and Cochrane Database of Systematic Reviews for articles published from 1974 to November 2013. Experts in the field were contacted for information about other ongoing or unpublished studies. A complementary search was conducted in the gray literature. Websites of national, provincial or regional agencies were searched for documents regarding policies surrounding the use of PD. Individual dialysis centers need to identify barriers to increasing PD in their program and direct targeted strategies to maximize PD utilization. Our review highlights some effective strategies that may be used. Our review also highlights the need for further research into strategies to maximize PD utilization.

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Calcium Metabolism following Renal Transplantation

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329403100202 ◽

1994 ◽

Vol 31 (2) ◽

pp. 125-128 ◽

Cited By ~ 11

Author(s):

Anne M Straffen ◽

DJS Carmichael ◽

Angela Fairney ◽

B Hulme ◽

M Snell

Keyword(s):

Renal Transplantation ◽

Calcium Homeostasis ◽

End Stage Renal Disease ◽

Post Transplantation ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Transplant Patients ◽

The Status ◽

Stage Renal Disease ◽

End Stage

Abnormalities of calcium homeostasis are a recognized feature of end-stage renal disease. The treatment of choice is renal transplantation, but this does not always result in normalization of the biochemical profile. Persistent hypercalcaemia is well documented and our study was undertaken to investigate the status of the calcium regulating hormones in renal patients post-transplantation. Serum calcium, parathyroid hormone, 1,25-dihydroxyvitamin D (1,25(OH)2D) and osteocalcin concentrations were measured in post-transplant patients. Twenty per cent of the patients had subnormal 1,25(OH)2D concentrations while 55% had biochemical evidence of hyperparathyroidism but only 5% were hypercalcaemic. Time elapsed since transplantation was not correlated with any of the analytes investigated and there was no relationship between persistent impairment of renal function and abnormalities of calcium homeostasis.

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