scholarly journals Honey clinically stimulates granulation and epithelialization in chronic wounds: a report of two cases

2018 ◽  
Vol 27 (1) ◽  
pp. 62-8 ◽  
Author(s):  
Putu E.P. Kefani ◽  
Ida B.A.D. Putra ◽  
Ratna R.N. Roosseno
Keyword(s):  
Side Effects ◽  
Sodium Bicarbonate ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Ulcer Patient ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Treatment

Various studies have been widely reintroduced honey as a wound dressing in chronic wound treatment. However, its utilization in Indonesia is still very limited. This study reported the effect of honey in stimulating the epithelialization and granulation on chronic wound treatment in our center. Two chronic wound cases, diabetic foot ulcer patient and gangrenous extravasation due to sodium bicarbonate, were daily treated with honey applications. After six-week evaluation, clinically the tissue granulation and epithelization were seen at the edge of the observed wounds and decreased the wound size significantly with no reported side effects. Honey clinically stimulates the epithelialization and granulation on chronic wound treatment.

scholarly journals Wound Myiasis in Diabetic Foot Ulcer: Calliphoridae and Sar-cophagidae Family

2021 ◽  
Author(s):  
Evren Tileklioğlu ◽  
İbrahim Yildiz ◽  
Fürüzan Bozkurt Kozan ◽  
Erdoğan Malatyali ◽  
Mustafa Bülent Ertuğrul ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Chronic Wound ◽  
Developmental Stages ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Foot Infections ◽  
Third Stage ◽  
Wound Myiasis

Background: Myiasis is a parasitic infestation of tissues or body cavities of mammals with dipterous larvae. The patients with diabetic foot ulcers are more vulnerable to acquiring infestation; however, the infestation may be neglected and mistreated in some cases.  Methods: Data were collected of twelve myiasis cases with diabetic foot ulcers in Nazli-Selim Eren Chronic Wound and Infections Care Unit, Aydin, Turkey between 2017 and 2019. Demographic, clinical characteristics of the patients and clinical examination of the wound were recorded. To morphology-based identification method of the agents, the developmental stages of the maggots were examined. Results: The cases aged between 46 and 81 years (10 males, two females). Eight of the larvae collected from wounds had Calliphoridae and four had Sarcophagidae family. The larvae were infested right/left foot sole, thumb, ankle, and mostly left toes. The number of larvae collected from the cases ranged from 2 to 48. Third-stage larvae (L3) were mostly detected. Mixed (L1-L2, L2-L3) larvae were detected in a patient. The infestations were more common in July and August. According to the score of Infectious Diseases Society of America (IDSA), ten (83%) cases had moderate and two (17%) cases were mild diabetic foot infections (DFIs). Conclusion: Diabetic foot ulcers should be evaluated in terms of myiasis. This was the first study in our province indicating that myiasis should not be neglected and different species of flies were responsible for myiasis cases.

scholarly journals Maggot debridement therapy for the treatment of diabetic foot ulcers: robbing the rich past to give to the sore

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Joseph Cutteridge ◽  
Katarzyna Bera
Keyword(s):  
Diabetic Foot ◽  
Chronic Wounds ◽  
Multiorgan Failure ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Necrotic Tissue ◽  
Foot Care ◽  
Surgical Interventions ◽  
Wound Debridement ◽  
Maggot Debridement Therapy

A diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus that results in significant morbidity and mortality. The lifetime risk of a patient with diabetes developing a DFU is 15-25%1. Furthermore, the incidence of DFUs is increasing in line with the growing burden of diabetes worldwide. The number of lower limb amputations secondary to diabetes has reached an all-time high in England, with 26,378 recorded from 2014-2017, an increase of 19.4% from 2010-20132. Maggot debridement therapy (MDT) involves the application of sterile larvae, usually of the species Lucilla sericata (common green bottle fly), which remove devitalised tissue to promote wound healing. This historical therapy re-emerged in the 1990s to combat the increasing incidence of recalcitrant wounds, such as DFUs. Since its reintroduction, there has been ongoing debate in the medical literature regarding the efficacy of MDT in the treatment of DFUs and other chronic wounds. We present the case of a 57-year-old male admitted with diabetic foot sepsis and multiorgan failure and discuss how MDT was used to complement initial surgical and antibiotic management. A 14-day course of MDT improved wound debridement and decreased necrotic tissue burden, after which no further surgical interventions were needed. This case provides further evidence that MDT is effective in the selective debridement of necrotic tissue and can aid the preservation of limb length in DFU patients, thereby highlighting the importance of MDT in multispecialist diabetic foot care.

scholarly journals A pharmacoeconomic study: cost-utility analysis of modern wound dressings vs conventional wound dressings in patients with diabetic foot ulcer

2021 ◽  
pp. 71-76
Author(s):  
Cyntiya Rahmawati ◽  
Baiq Leny Nopitasari
Keyword(s):  
Quality Of Life ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Pharmacoeconomic Study ◽  
Cost Utility ◽  
Wound Dressings ◽  
Duration Of Treatment

Introduction: Duration of treatment and outcome of therapy of diabetic foot ulcers are some of the factors that affect the quality of life and will require higher medical costs. Objectives: This study aimed to choose an alternative wound dressing that provides the best utility at the most cost-efficient. Methods: The research method used was pharmacoeconomics with a patient’s perspective. Results: The results showed the mean cost of modern wound dressings per visit was IDR 347,131, while that of conventional wound dressings was IDR 47,140. The quality of life with modern vs conventional wound dressing was significantly different (p < 0.05). The incremental cost utility ratio (ICUR) value was IDR 22,813 per quality of life (QoL). Conclusions: This study showed that modern wound dressings provide a higher quality of life at a higher cost. Indeed, it cost more than IDR 22,813 to change from conventional to modern wound dressings and increase 1 unit of quality of life, but patients obtained an additional 13.15 quality of life.

scholarly journals Three-Dimensional Human Tissue Models That Incorporate Diabetic Foot Ulcer-Derived Fibroblasts Mimic In Vivo Features of Chronic Wounds

2015 ◽  
Vol 21 (5) ◽  
pp. 499-508 ◽  
Author(s):  
Anna G. Maione ◽  
Yevgeny Brudno ◽  
Olivera Stojadinovic ◽  
Lara K. Park ◽  
Avi Smith ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Human Tissue ◽  
Chronic Wounds ◽  
Three Dimensional ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Tissue Models

scholarly journals Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair

2016 ◽  
Vol 24 (4) ◽  
pp. 630-643 ◽  
Author(s):  
Anna G. Maione ◽  
Avi Smith ◽  
Olga Kashpur ◽  
Vanessa Yanez ◽  
Elana Knight ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Wound Repair ◽  
Chronic Wound ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

The Effect of Kiwifruit Therapeutics in the Treatment of Diabetic Foot Ulcer

2021 ◽  
pp. 153473461985170
Author(s):  
Moien Kardoust ◽  
Hossein Salehi ◽  
Zahra Taghipour ◽  
Ahmadreza Sayadi
Keyword(s):  
Diabetic Foot ◽  
Wound Dressing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Surgical Debridement ◽  
Size Difference ◽  
Control Group ◽  
Treatment Comparison ◽  
Before And After ◽  
Experimental Group

Diabetes mellitus is considered a silent disease with possible late chronic complications such as diabetic foot ulcer. This condition is managed by surgical debridement. To improve surgical outcome, some surgeons use proteolytic agents after surgery. Kiwifruit contains a type of proteolytic enzyme called actinidin that may play a role in the treatment of such complication. In the current study, we evaluate the role of kiwifruit extract in the treatment of diabetic foot ulcer. Eighteen diabetic foot ulcer patients were included in a randomized, double-blind clinical trial. The patients were divided randomly to control and experimental groups. Patients in the control group underwent daily wound dressing using base ointment (Eucerin). In the experimental group, we added kiwifruit extract to the standard wound dressing. Clinical data including general appearance of wound (according to recorded photographs before and after medical intervention) were analyzed using SPSS version 22. The mean wound area of the experimental group was significantly less than in the control group ( P = .005) after 4 weeks of treatment. Comparison of the average of size difference, before and after the treatment in the experimental group and the control group, shows that kiwifruit can have a good impact on wound healing ( P = .0001). In patients with diabetic foot ulcer, wound dressing using kiwifruit extract may help reduce time of treatment and may replace surgical debridement for some selected cases.

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