scholarly journals Design sequences for sensory studies: Achieving balance for carry-over and position effects

2007 ◽  
Vol 60 (2) ◽  
pp. 339-349 ◽  
Author(s):  
B. A. S. Nonyane ◽  
C. M. Theobald
GeroPsych ◽  
2014 ◽  
Vol 27 (4) ◽  
pp. 161-169 ◽  
Author(s):  
Nienke A. Hofrichter ◽  
Sandra Dick ◽  
Thomas G. Riemer ◽  
Carsten Schleussner ◽  
Monique Goerke ◽  
...  

Hippocampal dysfunction and deficits in episodic memory have been reported for both Alzheimer’s disease (AD) and major depressive disorder (MDD). Primacy performance has been associated with hippocampus-dependent episodic memory, while recency may reflect working memory performance. In this study, serial position profiles were examined in a total of 73 patients with MDD, AD, both AD and MDD, and healthy controls (HC) by means of CERAD-NP word list memory. Primacy performance was most impaired in AD with comorbid MDD, followed by AD, MDD, and HC. Recency performance, on the other hand, was comparable across groups. These findings indicate that primacy in AD is impaired in the presence of comorbid MDD, suggesting additive performance decrements in this specific episodic memory function.


2014 ◽  
Vol 222 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Mareile Hofmann ◽  
Nathalie Wrobel ◽  
Simon Kessner ◽  
Ulrike Bingel

According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatment depends on the similarity of both treatments. We experimentally induced positive or negative experiences with a topical analgesic treatment in two groups of healthy human subjects. Subsequently, we compared responses to a second, unrelated and systemic analgesic treatment between both the positive and negative group. We found that there was no difference in the analgesic response to the second treatment between the two groups. Our data indicate that a change in administration route might reduce the influence of treatment history and therefore be a way to reduce negative carry-over effects after treatment failure. Future studies will have to validate these findings in a fully balanced design including larger, clinical samples.


2018 ◽  
Vol 226 (3) ◽  
pp. 152-163 ◽  
Author(s):  
Stephanie Mehl ◽  
Björn Schlier ◽  
Tania M. Lincoln

Abstract. Cognitive-behavioral therapy for psychosis (CBTp) builds on theoretical models that postulate reasoning biases and negative self-schemas to be involved in the formation and maintenance of delusions. However, it is unclear whether CBTp induces change in delusions by improving these proposed causal mechanisms. This study reports on a mediation analysis of a CBTp effectiveness trial in which delusions were a secondary outcome. Patients with psychosis were randomized to individualized CBTp (n = 36) or a waiting list condition (WL; n = 34). Reasoning biases (jumping to conclusions, theory of mind, attribution biases) and self-schemas (implicit and explicit self-esteem; self-schemas related to different domains) were assessed pre- and post-therapy/WL. The results reveal an intervention effect on two of four measures of delusions and on implicit self-esteem. Nevertheless, the intervention effect on delusions was not mediated by implicit self-esteem. Changes in explicit self-schemas and reasoning biases did also not mediate the intervention effects on delusions. More focused interventions may be required to produce change in reasoning and self-schemas that have the potential to carry over to delusions.


2020 ◽  
Vol 117 (6) ◽  
pp. 619
Author(s):  
Rui Xu ◽  
Haitao Ling ◽  
Haijun Wang ◽  
Lizhong Chang ◽  
Shengtao Qiu

The transient multiphase flow behavior in a single-strand tundish during ladle change was studied using physical modeling. The water and silicon oil were employed to simulate the liquid steel and slag. The effect of the turbulence inhibitor on the slag entrainment and the steel exposure during ladle change were evaluated and discussed. The effect of the slag carry-over on the water-oil-air flow was also analyzed. For the original tundish, the top oil phase in the impact zone was continuously dragged into the tundish bath and opened during ladle change, forming an emulsification phenomenon. By decreasing the liquid velocities in the upper part of the impact zone, the turbulence inhibitor decreased considerably the amount of entrained slag and the steel exposure during ladle change, thereby eliminating the emulsification phenomenon. Furthermore, the use of the TI-2 effectively lowered the effect of the slag carry-over on the steel cleanliness by controlling the movement of slag droplets. The results from industrial trials indicated that the application of the TI-2 reduced considerably the number of linear inclusions caused by ladle change in hot-rolled strip coils.


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