scholarly journals Development of acid-sensitive copolymer micelles for drug delivery

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1295-1307 ◽  
Author(s):  
E. R. Gillies ◽  
J. M. J. Fréchet
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Acidic Ph ◽  
Potential Drug ◽  
Specific Location ◽  
Copolymer Micelles ◽  
Direct Attachment

In recent years, supramolecular micellar assemblies formed from amphiphilic block copolymers have been receiving attention as potential drug carriers. The size of the carriers is ideal for avoiding rapid renal exclusion and reticuloendothelial uptake, and enables them to be targeted to certain tissues such as tumors. One important issue determining the effectiveness of a micellar drug carrier is the ability to control the time over which drug release takes place, or to possibly trigger drug release at a specific location or time. The mildly acidic pH encountered in tumor and inflammatory tissues as well as in the endosomal and lysosomal compartments of cells has inspired the development of micellar carriers capable of releasing their drug load in response to small changes in pH. One approach to the development of these systems has been to incorporate “titratable” groups such as amines and carboxylic acids into the copolymer backbone, thus altering the solubility of the polymer upon protonation and disrupting micelle formation. Another approach has been to incorporate acid-degradable linkages into the copolymer, either for direct attachment of the drug, or to cause a structural change of such magnitude that micellar integrity is lost and the drug is released.

Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38810-38817 ◽  
Author(s):  
Yeping Li ◽  
Jingbo Xu ◽  
Yun Xu ◽  
Liying Huang ◽  
Junli Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Zns Nanoparticles ◽  
New Approach ◽  
Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

scholarly journals Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6142
Author(s):  
Bożena Łosiewicz ◽  
Agnieszka Stróż ◽  
Patrycja Osak ◽  
Joanna Maszybrocka ◽  
Anna Gerle ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Drug Release ◽  
Room Temperature ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Potential Drug ◽  
Voltage Range ◽  
Inflammatory Conditions ◽  
Drug Eluting

This work concerns the development of a method of functionalization of the surface of the biomedical Ti–6Al–7Nb alloy by producing oxide nanotubes (ONTs) with drug-eluting properties. Shaping of the morphology, microstructure, and thickness of the oxide layer was carried out by anodization in an aqueous solution of 1 M ethylene glycol with the addition of 0.2 M NH4F in the voltage range 5–100 V for 15–60 min at room temperature. The characterization of the physicochemical properties of the obtained ONTs was performed using SEM, XPS, and EDAX methods. ONTs have been shown to be composed mainly of TiO2, Al2O3, and Nb2O5. Single-walled ONTs with the largest specific surface area of 600 cm2 cm−2 can be obtained by anodization at 50 V for 60 min. The mechanism of ONT formation on the Ti–6Al–7Nb alloy was studied in detail. Gentamicin sulfate loaded into ONTs was studied using FTIR, TG, DTA, and DTG methods. Drug release kinetics was determined by UV–Vis spectrophotometry. The obtained ONTs can be proposed for use in modern implantology as carriers for drugs delivered locally in inflammatory conditions.

Preparation and characterization of N-phthaloyl-chitosan-g-(PEO–PLA–PEO) as a potential drug carrier

RSC Advances ◽  
2015 ◽  
Vol 5 (120) ◽  
pp. 99418-99424 ◽  
Author(s):  
Jinda Fang ◽  
Ke Zhang ◽  
Jingwei Jia ◽  
Zhengke Wang ◽  
Qiaoling Hu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Drug Loading ◽  
Potential Drug ◽  
Release Profiles

Synthesis of N-phthaloyl-chitosan-g-(PEO–PLA–PEO) and its drug loading capacities and drug release profiles of IMC.

scholarly journals Formulation and Evaluation of Controlled Release Maintenance Dose Loaded Niosomes of Anti-Hypertensive Drug

2019 ◽  
Vol 11 (06) ◽  
Author(s):  
Chandani Makvana ◽  
Satyajit Sahoo
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Zeta Potential ◽  
Drug Carrier ◽  
Entrapment Efficiency ◽  
Drug Carriers ◽  
Vesicle Size ◽  
Drug Content ◽  
Span 60

The present study was aimed to formulate, comparatively evaluate and optimize multiple lipid drug carriers of valsartan for oral controlled release to overcome the problems associated with the drug such as bioavailability, to reduce the dosage regimen, half life and to determine the appropriateness of niosomal formulation as a drug carrier. Ether injection method was chosen for the formulation of physically and chemically stable niosomes of valsartan. The formulation and process parameters were optimized by manufacturing placebo niosomes. Than drug loaded niosome was prepared by varying the concentration of span 60. The prepared nine formulations were evaluated for various parameters. Placebo niosomes were evaluated for appearance, odour, texture, creaming volume, pH and changes after 15 days. The medicated nine formulations were evaluated for organoleptic properties (appearance/color, odour), pH, total drug content, entrapment efficiency, mean particle size and polydispersibility index, zeta potential and In-vitro drug release. All formulations were off-white in color, odourless, and fluid in nature. It was stable and did not show sedimentation. The pH was found to be in the range of 4.6-5.4. Drug content was found in the range of 89.13 to 99.52. The Entrapment efficiency was found in range of 79.05 to 98.24. The mean vesicle size of drug loaded niosomes of the different batches ranged between 2.52-3.42μm. The polydispersvity index was in the range of 0.325 to 0.420 which indicates a narrow vesicle size distribution. The values of zeta potential were in the range of -20.29 mV to -30.55 mV which indicates that niosome had sufficient charge and mobility to inhibit aggregation of vesicles. All the nine formulations shows constant drug release in controlled manner up to 24 h. Formulation V7 was considered to be the best formulation as the % drug content (99.52 ± 0.97), % entrapment efficiency (98.24 ± 1.50) and % drug release at the end of 24th h (98.55) were high for V7. The optimized formulation V7 showed higher degree of correlation coefficient (r2) 0.9805 which indicates process of constant drug release from dosage form. The present study concludes that the prepared niosome is a convenient and efficiency carrier for the delivery of antihypertensive drug. Besides this, it provided controlled delivery of drug.

Thermoresponsive block copolymer micelles with tunable pyrrolidone-based polymer cores: structure/property correlations and application as drug carriers

2015 ◽  
Vol 3 (5) ◽  
pp. 814-823 ◽  
Author(s):  
X.-L. Sun ◽  
P.-C. Tsai ◽  
R. Bhat ◽  
E. M. Bonder ◽  
B. Michniak-Kohn ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Drug Release ◽  
Physicochemical Properties ◽  
Drug Loading ◽  
Drug Carriers ◽  
Structure Property ◽  
Loading Efficiency ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Drug Loading Efficiency

Residue structure affects the physicochemical properties, drug loading efficiency, and thermoresponsive drug release profiles of block copolymer micelles with pyrrolidone-based polymer cores.

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