Optical coherence tomography-integrated, wearable (backpack-type), compact diagnostic imaging modality for in situ leaf quality assessment

Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality, and clinical utility in management decisions were recorded. Results: Eighty-two eyes from 72 patients were included. Patients were aged 59.4 ± 17.1 years (range, 8-87 years). During imaging, 4.4 series of images were obtained in 4.1 minutes, with 86.4% of the image series deemed to be diagnostic of the peripheral pathology on blinded image review. The most common pathologic findings were chorioretinal scars (18 eyes). In 31 (38%) eyes, these images were meaningful in supporting clinical decision-making with definitive findings. Diagnoses imaged included retinal detachment combined with retinoschisis, retinal hole with overlying vitreous traction and subretinal fluid, vitreous inflammation overlying a peripheral scar, Coats disease, and peripheral retinal traction in sickle cell retinopathy. Conclusions: Navigated UWF SS-OCT imaging was clinically practical and provided high-quality characterization of peripheral retinal lesions for all eyes. Images directly contributed to management plans, including laser, injection or surgical treatment, for a clinically meaningful set of patients (38%). Future studies are needed to further assess the value of this imaging modality and its role in diagnosing, monitoring, and treating peripheral lesions.

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Synthetic polarization-sensitive optical coherence tomography by deep learning

npj Digital Medicine ◽

10.1038/s41746-021-00475-8 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Yi Sun ◽

Jianfeng Wang ◽

Jindou Shi ◽

Stephen A. Boppart

Keyword(s):

Optical Coherence Tomography ◽

Deep Learning ◽

Imaging System ◽

Imaging Modality ◽

Similarity Index ◽

Polarization Sensitivity ◽

Imaging Method ◽

Optical Coherence ◽

The Real ◽

Oct Imaging

AbstractPolarization-sensitive optical coherence tomography (PS-OCT) is a high-resolution label-free optical biomedical imaging modality that is sensitive to the microstructural architecture in tissue that gives rise to form birefringence, such as collagen or muscle fibers. To enable polarization sensitivity in an OCT system, however, requires additional hardware and complexity. We developed a deep-learning method to synthesize PS-OCT images by training a generative adversarial network (GAN) on OCT intensity and PS-OCT images. The synthesis accuracy was first evaluated by the structural similarity index (SSIM) between the synthetic and real PS-OCT images. Furthermore, the effectiveness of the computational PS-OCT images was validated by separately training two image classifiers using the real and synthetic PS-OCT images for cancer/normal classification. The similar classification results of the two trained classifiers demonstrate that the predicted PS-OCT images can be potentially used interchangeably in cancer diagnosis applications. In addition, we applied the trained GAN models on OCT images collected from a separate OCT imaging system, and the synthetic PS-OCT images correlate well with the real PS-OCT image collected from the same sample sites using the PS-OCT imaging system. This computational PS-OCT imaging method has the potential to reduce the cost, complexity, and need for hardware-based PS-OCT imaging systems.

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Optical coherence tomography for the in situ three-dimensional visualization and quantification of feed spacer channel fouling in reverse osmosis membrane modules

Journal of Membrane Science ◽

10.1016/j.memsci.2015.09.047 ◽

2016 ◽

Vol 498 ◽

pp. 345-352 ◽

Cited By ~ 47

Author(s):

Stephanie West ◽

Michael Wagner ◽

Cosima Engelke ◽

Harald Horn

Keyword(s):

Optical Coherence Tomography ◽

Reverse Osmosis ◽

Three Dimensional ◽

Optical Coherence ◽

Reverse Osmosis Membrane ◽

Membrane Modules

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Abstract 18844: Diagnosis of Thin-capped Fibroatheromas in Intravascular Optical Coherence Tomography Images: Effects of Light Scattering

Circulation ◽

10.1161/circ.132.suppl_3.18844 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Taylor Hoyt ◽

Jennifer Phipps ◽

Deborah Vela ◽

Tianyi Wang ◽

Maximillian Buja ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Light Scattering ◽

Coronary Arteries ◽

Foam Cell ◽

Imaging Modality ◽

Fibrous Tissue ◽

Image Feature ◽

Optical Coherence ◽

Fibrous Cap ◽

Intravascular Optical Coherence Tomography

Objectives: Intravascular optical coherence tomography (IVOCT) images are recorded by detecting light backscattered within coronary arteries. We hypothesize that non- thin-cap fibroatheroma (TCFA) etiologies may scatter light to create the false appearance of IVOCT TCFA. Background: Conflicting reports are recognized about the accuracy of IVOCT for TCFA detection. Methods: Ten human cadaver hearts were imaged with IVOCT (N=14 arteries). Coronary arteries were sectioned at 120 μm intervals. IVOCT and histologic TCFA were co-registered and compared. Results: Of 21 IVOCT TCFAs identified by two independent IVOCT core labs (fibrous cap <65 μm, lipid arc >90°), only 8 were true histologic TCFA. Foam cell infiltration was responsible for 62% of cases in which either thick-capped fibroatheromas (ThKFAs) appeared like TCFAs or arterial tissue appeared like TCFAs when no lipid core was present. Other false IVOCT TCFA etiologies included SMC-rich fibrous tissue (15%) and loose connective tissue (8%). If the lipid arc >90° criterion was disregarded, 45 IVOCT TCFAs were identified, and sensitivity of IVOCT TCFA detection increased from 53% to 88%; specificity remained high at 93%, and the presence of a new IVOCT image feature called “bright streaks” increased positive predictive value (PPV) to 53%. New mechanisms for light scattering are proposed to explain the low PPV of IVOCT to identify true TCFA (44%), and explain why other plaque components can masquerade as IVOCT TCFA. Conclusions: IVOCT can exhibit up to 88% sensitivity and 98% specificity to detect TCFA, but PPV is limited due to multiple etiologies that cause light scattering similar to true TCFA. Disregarding the lipid arc >90° IVOCT TCFA requirement, and the identification of a new feature, bright steaks, can enhance the ability of IVOCT to detect TCFA. Combining IVOCT with another imaging modality that more specifically recognizes lipid will be important for increasing PPV in the future.

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In Situ Circular Compression and Doppler Optical Coherence Tomography Studies on Effects of Diabetic Mellitus on Vesa Nervonum of Sciatic Nerve

IFMBE Proceedings - 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering ◽

10.1007/978-3-319-12262-5_13 ◽

2015 ◽

pp. 42-45

Author(s):

Eric Chia ◽

Chou-Chin Lin ◽

Chung-Yi Sue ◽

Ming-Shaung Ju

Keyword(s):

Optical Coherence Tomography ◽

Sciatic Nerve ◽

Optical Coherence ◽

Diabetic Mellitus ◽

Doppler Optical Coherence Tomography

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Optical Coherence Tomography for the Detection of Laser In Situ Keratomileusis in Donor Corneas

Cornea ◽

10.1097/00003226-200301000-00011 ◽

2003 ◽

Vol 22 (1) ◽

pp. 46-50 ◽

Cited By ~ 28

Author(s):

Siegfried G. Priglinger ◽

Aljoscha S. Neubauer ◽

Christian-Albrecht May ◽

Claudia S. Alge ◽

Armin H. Wolf ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Laser In Situ Keratomileusis ◽

Optical Coherence ◽

Donor Corneas

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In-situ assessment of biofilm formation in submerged membrane system using optical coherence tomography and computational fluid dynamics

Journal of Membrane Science ◽

10.1016/j.memsci.2016.09.004 ◽

2017 ◽

Vol 521 ◽

pp. 84-94 ◽

Cited By ~ 40

Author(s):

Luca Fortunato ◽

Adnan Qamar ◽

Yiran Wang ◽

Sanghyun Jeong ◽

TorOve Leiknes

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Optical Coherence Tomography ◽

Biofilm Formation ◽

Membrane System ◽

Optical Coherence ◽

In Situ Assessment

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Optical Coherence Tomography and Glaucoma

Annual Review of Vision Science ◽

10.1146/annurev-vision-100419-111350 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Alexi Geevarghese ◽

Gadi Wollstein ◽

Hiroshi Ishikawa ◽

Joel S. Schuman

Keyword(s):

Optical Coherence Tomography ◽

Adaptive Optics ◽

Imaging Modality ◽

Annual Review ◽

Publication Date ◽

Optical Coherence ◽

Swept Source ◽

Diagnosis And Management ◽

Spectral Domain Oct ◽

Glaucoma Diagnosis

Early detection and monitoring are critical to the diagnosis and management of glaucoma, a progressive optic neuropathy that causes irreversible blindness. Optical coherence tomography (OCT) has become a commonly utilized imaging modality that aids in the detection and monitoring of structural glaucomatous damage. Since its inception in 1991, OCT has progressed through multiple iterations, from time-domain OCT, to spectral-domain OCT, to swept-source OCT, all of which have progressively improved the resolution and speed of scans. Even newer technological advancements and OCT applications, such as adaptive optics, visible-light OCT, and OCT-angiography, have enriched the use of OCT in the evaluation of glaucoma. This article reviews current commercial and state-of-the-art OCT technologies and analytic techniques in the context of their utility for glaucoma diagnosis and management, as well as promising future directions. Expected final online publication date for the Annual Review of Vision Science, Volume 7 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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