Diffuse optical spectroscopy: A non-invasive monitor of breast tissue disease state?

2003 ◽  
Author(s):  
Albert Cerussi
Keyword(s):  
Optical Spectroscopy ◽  
Breast Tissue ◽  
Disease State ◽  
Diffuse Optical Spectroscopy ◽  
Non Invasive

scholarly journals Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine

2018 ◽  
Vol 183 (suppl_1) ◽  
pp. 150-156
Author(s):  
Jesse H Lam ◽  
Thomas D O’Sullivan ◽  
Tim S Park ◽  
Jae H Choi ◽  
Robert V Warren ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Massive Hemorrhage ◽  
Balloon Occlusion ◽  
Total Blood ◽  
Diffuse Optical Spectroscopy ◽  
Hemoglobin Oxygen Saturation ◽  
Non Invasive ◽  
Dual Channel ◽  
Tissue Compartments ◽  
Endovascular Balloon Occlusion

Abstract Objective To quantitatively measure tissue composition and hemodynamics during resuscitative endovascular balloon occlusion of the aorta (REBOA) in two tissue compartments using non-invasive two-channel broadband diffuse optical spectroscopy (DOS). Methods Tissue concentrations of oxy- and deoxyhemoglobin (HbO2 and HbR), water, and lipid were measured in a porcine model (n = 10) of massive hemorrhage (65% total blood volume over 1 h) and 30-min REBOA superior and inferior to the aortic balloon. Results After hemorrhage, hemoglobin oxygen saturation (StO2 = HbO2/[HbO2 + HbR]) at both sites decreased significantly (−29.9% and −42.3%, respectively). The DOS measurements correlated with mean arterial pressure (MAP) (R2 = 0.79, R2 = 0.88), stroke volume (SV) (R2 = 0.68, R2 = 0.88), and heart rate (HR) (R2 = 0.72, R2 = 0.88). During REBOA, inferior StO2 continued to decline while superior StO2 peaked 12 min after REBOA before decreasing again. Inferior DOS parameters did not associate with MAP, SV, or HR during REBOA. Conclusions Dual-channel regional tissue DOS measurements can be used to non-invasively track the formation of hemodynamically distinct tissue compartments during hemorrhage and REBOA. Conventional systemic measures MAP, HR, and SV are uncorrelated with tissue status in inferior (downstream) sites. Multi-compartment DOS may provide a more complete picture of the efficacy of REBOA and similar resuscitation procedures.

Non-Invasive Monitoring of Cyanide Toxicity Using Diffuse Optical Spectroscopy in a Rabbit Model

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 874S
Author(s):  
Jennifer Armstrong ◽  
Jangwoen Lee ◽  
Andrew Duke ◽  
Hamza Beydoun ◽  
Kelly Kreuter ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Rabbit Model ◽  
Invasive Monitoring ◽  
Diffuse Optical Spectroscopy ◽  
Cyanide Toxicity ◽  
Non Invasive

Diffuse optical spectroscopy of breast tissue extended to 1100 nm

2009 ◽  
Vol 14 (5) ◽  
pp. 054030 ◽  
Author(s):  
Paola Taroni ◽  
Andrea Bassi ◽  
Daniela Comelli ◽  
Andrea Farina ◽  
Rinaldo Cubeddu ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Breast Tissue ◽  
Diffuse Optical Spectroscopy

scholarly journals THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT)

2019 ◽  
Vol 18 (4) ◽  
pp. 92-101
Author(s):  
M. V. Pavlov ◽  
S. A. Pegov ◽  
A. G. Orlova ◽  
G. Yu. Golubyatnikov ◽  
L. V. Shkalova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Spectroscopy ◽  
Malignant Tumor ◽  
Breast Tissue ◽  
Cancer Metastasis ◽  
Optical Methods ◽  
Imaging Modalities ◽  
Cancer Case ◽  
Axillary Lymph ◽  
Diffuse Optical Spectroscopy

Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related death in women worldwide. Currently, mammography and ultrasound are the methods most commonly used for the detection of BC, but these methods have significant limitations in the absence of “classic” visual symptoms of cancer in the breast tissue. In the complicated clinical situations, such methods as magnetic resonance imaging and positron emission tomography are used for the differential diagnosis of breast cancer. Over the past 20 years, the BC imaging capabilities have expanded due to the introduction of optical methods into clinical practice. These methods are based on differences in the optical properties between normal and pathological breast tissues. Optical imaging provides the ability to obtain indirect information about oxygenation, blood supply, delivery and consumption of oxygen in the breast tissue, as well as changes in its scattering properties. We present a clinical case of a woman with enlarged axillary lymph nodes. After the core biopsy of the lymph node, histological examination reveled breast cancer metastasis. The standard imaging modalities, such as digital mammography and ultrasound, did not show the evidence of breast cancer. However, the use of diffuse optical spectroscopy (DOS) allowed the detection of changes in the absorption and scattering coefficients in a small part of the breast tissue characteristic of a malignant tumor. Ultrasound and mammography images of this site of the breast demonstrated the features of benign lesion. After ultrasound-guided biopsy, cytological examination revealed cancer cells. Thus, the method of DOS allowed identification of changes characteristic to malignant tumor that was not detected by routine imaging modalities.

200 NON-INVASIVE DETECTION OF CYANIDE TOXICITY AND TREATMENT USING DIFFUSE OPTICAL SPECTROSCOPY

2005 ◽  
Vol 53 (1) ◽  
pp. S113.2-S113
Author(s):  
K. Kreuter ◽  
J. Lee ◽  
J. Armstrong ◽  
B. Tromberg ◽  
S. Mahon ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Diffuse Optical Spectroscopy ◽  
Cyanide Toxicity ◽  
Non Invasive

scholarly journals The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer

2004 ◽  
Vol 19 (2-3) ◽  
pp. 95-105 ◽  
Author(s):  
Natasha Shah ◽  
Albert E. Cerussi ◽  
Dorota Jakubowski ◽  
David Hsiang ◽  
John Butler ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Breast Tissue ◽  
Malignant Tumors ◽  
Hormone Replacement ◽  
Menopausal Status ◽  
Normal Breast ◽  
Response To Therapy ◽  
Diffuse Optical Spectroscopy ◽  
Measured Absorption ◽  
Scattering Spectra

Diffuse optical spectroscopy (DOS) of breast tissue provides quantitative, functional information based on optical absorption and scattering properties that cannot be obtained with other radiographic methods. DOS-measured absorption spectra are used to determine the tissue concentrations of deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), lipid, and water (H2O), as well as to provide an index of tissue hemoglobin oxygen saturation (StO2). Tissue-scattering spectra provide insight into epithelial, collagen, and lipid contributions to breast density. Clinical studies of women with malignant tumors show that DOS is sensitive to processes such as increased tissue vascularization, hypoxia, and edema. In studies of healthy women, DOS detects variations in breast physiology associated with menopausal status, menstrual cycle changes, and hormone replacement. Current research involves using DOS to monitor tumor response to therapy and the co-registration of DOS with magnetic resonance imaging. By correlating DOS-derived parameters with lesion pathology and specific molecular markers, we anticipate that composite “tissue optical indices” can be developed that non-invasively characterize both tumor and normal breast-tissue function.

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