LC–MS–MS Analysis of Strictosamide in Rat Plasma, and Application of the Method to a Pharmacokinetic Study

2009 ◽  
Vol 69 (9-10) ◽  
pp. 1073-1076 ◽  
Author(s):  
Xin Hu ◽  
Yun-Feng Lv ◽  
Kai-Shun Bi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Ms Analysis

LC-MS/MS analysis of two new designer drugs (FLY serie) in rat plasma and its application to a pharmacokinetic study

2019 ◽  
Vol 38 ◽  
pp. 58-63 ◽  
Author(s):  
Elena Baralla ◽  
Maria Nieddu ◽  
Lucia Burrai ◽  
Maria Vittoria Varoni ◽  
Maria Piera Demontis ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Designer Drugs ◽  
Ms Analysis

Quantification of annonacin in Rat plasma: Application to pharmacokinetic study

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
N Bonneau ◽  
I Schmitz Afonso ◽  
D Touboul ◽  
A Brunelle ◽  
P Champy
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma

LC–MS/MS Determination of Apigenin in Rat Plasma and Application to Pharmacokinetic Study

2020 ◽  
Vol 21 ◽  
Author(s):  
Shixing Zhu ◽  
Jiayuan Zhang ◽  
Zhihua Lv ◽  
Mingming Yu
Keyword(s):  
Formic Acid ◽  
Pharmacokinetic Study ◽  
Ammonium Acetate ◽  
Rat Plasma ◽  
Biological Properties ◽  
Plasma Samples ◽  
Supply Rate ◽  
Natural Plant ◽  
Ammonium Acetate Buffer

Background: Apigenin, a natural plant flavone, has been shown to possess a variety of biological properties. Objective: In this report, a highly selective and sensitive LC-MS/MS method was developed and validated for the determination of apigenin in rat plasma. Methods: Analysts were separated on the HSS T3 column (1.8 μm 2.1×100 mm) using acetonitrile and 0.1% formic acid in 2 mM ammonium acetate buffer at a supply rate of 0.200 mL/min as eluent in gradient model. Results: Plasma samples were treated by protein precipitation using acetonitrile for the recovery ranging from 86.5% to 90.1% for apigenin. The calibration curves followed linearity in the concentration range of 0.50-500 ng/mL. The inter-day and intra-day precisions at different QC levels within 13.1% and the accuracies ranged from -10.6% to 8.6%. Conclusion: The assay has been successfully applied to the pharmacokinetic study of apigenin in rats.

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