scholarly journals Histidine Decarboxylase, DOPA Decarboxylase, and Vesicular Monoamine Transporter 2 Expression in Neuroendocrine Tumors: Immunohistochemical Study and Gene Expression Analysis

2006 ◽  
Vol 54 (8) ◽  
pp. 863-875 ◽  
Author(s):  
Silvia Uccella ◽  
Roberta Cerutti ◽  
Davide Vigetti ◽  
Daniela Furlan ◽  
Rita Oldrini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroendocrine Tumors ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Histidine Decarboxylase ◽  
Immunohistochemical Study ◽  
Dopa Decarboxylase ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2

scholarly journals Integrating a 92-Gene Expression Analysis for the Management of Neuroendocrine Tumors of Unknown Primary

2019 ◽  
Vol 20 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Aman Chauhan ◽  
Zainab Farooqui ◽  
Scott R Silva ◽  
Le Aundra Murray ◽  
Kurt B Hodges ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroendocrine Tumors ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Unknown Primary

Sequencing, Characterization, and Gene Expression Analysis of the Histidine Decarboxylase Gene Cluster of Morganella morganii

2013 ◽  
Vol 68 (3) ◽  
pp. 404-411 ◽  
Author(s):  
Chiara Ferrario ◽  
Francesca Borgo ◽  
Blanca de las Rivas ◽  
Rosario Muñoz ◽  
Giovanni Ricci ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Cluster ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Histidine Decarboxylase ◽  
Morganella Morganii

scholarly journals Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors

2017 ◽  
Vol 107 (1) ◽  
pp. 1-23
Author(s):  
Franziska Briest ◽  
Irina Grass ◽  
Dagmar Sedding ◽  
Markus Möbs ◽  
Friederike Christen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Western Blot ◽  
Neuroendocrine Tumors ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Neuroendocrine Neoplasms ◽  
Wild Type ◽  
Frequent Event ◽  
P53 Response

Background/Aims: The tumor suppressor p53 is rarely mutated in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) but they frequently show a strong expression of negative regulators of p53, rendering these tumors excellent targets for a p53 recovery therapy. Therefore, we analyzed the mechanisms of a p53 recovery therapy on intestinal neuroendocrine tumors in vitro and in vivo.Methods: By Western blot and immunohistochemistry, we found that in GEP-NEN biopsy material overexpression of MDM2 was present in intestinal NEN. Therefore, we analyzed the effect of a small-molecule inhibitor, nutlin-3a, in p53 wild-type and mutant GEP-NEN cell lines by proliferation assay, flow cytometry, immunofluorescence, Western blot, and by multiplex gene expression analysis. Finally, we analyzed the antitumor effect of nutlin-3a in a xenograft mouse model in vivo. During the study, the tumor volume was determined. Results: The midgut wild-type cell line KRJ-I responded to the treatment with cell cycle arrest and apoptosis. By gene expression analysis, we could demonstrate that nutlins reactivated an antiproliferative p53 response. KRJ-I-derived xenograft tumors showed a significantly decreased tumor growth upon treatment with nutlin-3a in vivo. Furthermore, our data suggest that MDM2 also influences the expression of the oncogene FOXM1 in a p53-independent manner. Subsequently, a combined treatment of nutlin-3a and cisplatin (as chemoresistance model) resulted in synergistically enhanced antiproliferative effects. Conclusion: In summary, MDM2 overexpression is a frequent event in p53 wild-type intestinal neuroendocrine neoplasms and therefore recovery of a p53 response might be a novel personalized treatment approach in these tumors.

Localization of sporadic neuroendocrine tumors by gene expression analysis of their metastases

2011 ◽  
Vol 28 (7) ◽  
pp. 637-647 ◽  
Author(s):  
Nicole Posorski ◽  
Daniel Kaemmerer ◽  
Guenther Ernst ◽  
Patricia Grabowski ◽  
Dieter Hoersch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroendocrine Tumors ◽  
Expression Analysis ◽  
Gene Expression Analysis
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