scholarly journals High-Frequency, Low-Magnitude Vibration Does Not Prevent Bone Loss Resulting from Muscle Disuse in Mice following Botulinum Toxin Injection

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36486 ◽  
Author(s):  
Sarah L. Manske ◽  
Craig A. Good ◽  
Ronald F. Zernicke ◽  
Steven K. Boyd
Keyword(s):  
Botulinum Toxin ◽  
Bone Loss ◽  
High Frequency ◽  
Botulinum Toxin Injection ◽  
Prevent Bone Loss ◽  
Muscle Disuse ◽  
Low Magnitude

Muscle Changes Can Account for Bone Loss After Botulinum Toxin Injection

2010 ◽  
Vol 87 (6) ◽  
pp. 541-549 ◽  
Author(s):  
Sarah L. Manske ◽  
Steven K. Boyd ◽  
Ronald F. Zernicke
Keyword(s):  
Botulinum Toxin ◽  
Bone Loss ◽  
Botulinum Toxin Injection ◽  
Muscle Changes

scholarly journals Protective effects of low-magnitude high-frequency vibration on high glucose-induced osteoblast dysfunction and bone loss in diabetic rats

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhaoyu Fu ◽  
Xu Huang ◽  
Pengcheng Zhou ◽  
Bo Wu ◽  
Long Cheng ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Protective Effect ◽  
High Glucose ◽  
High Frequency ◽  
Biomechanical Properties ◽  
Matrix Composition ◽  
Protective Effects ◽  
High Frequency Vibration ◽  
Low Magnitude

Abstract Objective Low-magnitude high-frequency vibration (LMHFV) has been reported to be capable of promoting osteoblast proliferation and differentiation. Reduced osteoblast activity and impaired bone formation were related to diabetic bone loss. We investigated the potential protective effects of LMHFV on high-glucose (HG)-induced osteoblasts in this study. In addition, the assessment of LMHFV treatment for bone loss attributed to diabetes was also performed in vivo. Method MC3T3-E1 cells induced by HG only or treated with LMHFV were treated in vitro. The experiments performed in this study included the detection of cell proliferation, migration and differentiation, as well as protein expression. Diabetic bone loss induced by streptozotocin (STZ) in rats was established. Combined with bone morphometric, microstructure, biomechanical properties and matrix composition tests, the potential of LMHFV in treating diabetes bone loss was explored. Results After the application of LMHFV, the inhibiting effects of HG on the proliferation, migration and differentiation of osteoblasts were alleviated. The GSK3β/β-catenin pathway was involved in the protective effect of LMHFV. Impaired microstructure and biomechanical properties attributed to diabetes were ameliorated by LMHFV treatment. The improvement of femur biomechanical properties might be associated with the alteration of the matrix composition by the LMHFV. Conclusion LMHFV exhibited a protective effect on osteoblasts against HG by regulating the proliferation, migration and differentiation of osteoblasts. The function of promoting bone formation and reinforcing bone strength made it possible for LMHFV to alleviate diabetic bone loss.

Persistent Diplopia in Visually Mature Patients. Is it Intractable or something else? A Review and Case Series

2017 ◽  
pp. 90-108
Keyword(s):  
Botulinum Toxin ◽  
Extraocular Muscle ◽  
Botulinum Toxin Injection ◽  
Case Series ◽  
Sensory Adaptation ◽  
Single Vision ◽  
Injection Treatment ◽  
Vision Therapy ◽  
Extraocular Muscle Surgery

Diplopia is described as being intractable when there is inability to both fuse the two images and suppress the second image. Intractable diplopia persists despite achieving ocular alignment using either prisms, lenses,vision therapy,extraocular muscle surgery, or botulinum toxin injection. Treatment usually resorts to occluding or fogging the patient’s nondominant eye. Often times, however, adults having other causative mechanisms for supposedly persistent diplopia are able to achieve comfortable single vision with treatment that either establishes fusion or reactivates a preexisting sensory adaptation. This case series reviews these other causes of diplopia.

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