scholarly journals Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e44148 ◽  
Author(s):  
Sarina Meinen ◽  
Shuo Lin ◽  
Markus A. Rüegg ◽  
Anna Rostedt Punga
Keyword(s):  
Mouse Model ◽  
Myasthenia Gravis ◽  
Muscle Atrophy

3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis

2012 ◽  
Vol 245 (1-2) ◽  
pp. 75-78 ◽  
Author(s):  
Shuuichi Mori ◽  
Masahiko Kishi ◽  
Sachiho Kubo ◽  
Takuyu Akiyoshi ◽  
Shigeru Yamada ◽  
...  
Keyword(s):  
Mouse Model ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission

scholarly journals Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 420
Author(s):  
Laura C. Gunder ◽  
Innocence Harvey ◽  
JeAnna R. Redd ◽  
Carol S. Davis ◽  
Ayat AL-Tamimi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Lean Mass ◽  
Muscle Fibers ◽  
Muscle Size ◽  
Type Ii ◽  
Obese Mice ◽  
Diet Induced Obesity ◽  
Synthetic Glucocorticoid

Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together, these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy.

G.P.27 Muscle atrophy in the GNE myopathy mouse model is associated with oxidative stress

2012 ◽  
Vol 22 (9-10) ◽  
pp. 816 ◽  
Author(s):  
A. Cho ◽  
M.C. Malicdan ◽  
I. Nonaka ◽  
Y.K. Hayashi ◽  
I. Nishino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Gne Myopathy

scholarly journals Congenital exercise ability ameliorates muscle atrophy but not spinal cord recovery in spinal cord injury mouse model

2019 ◽  
Vol 16 (12) ◽  
pp. 1549-1556 ◽  
Author(s):  
Po-An Tai ◽  
Yi-Ju Hsu ◽  
Wen-Ching Huang ◽  
Chun-Hao Chang ◽  
Yi-Hsun Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Cord Injury

scholarly journals Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129686 ◽  
Author(s):  
Giulia Maria Camerino ◽  
Jean-François Desaphy ◽  
Michela De Bellis ◽  
Roberta Francesca Capogrosso ◽  
Anna Cozzoli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Biology ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Skeletal Muscle Atrophy ◽  
Functional Evaluation ◽  
Muscle Disuse

AchR-positive myasthenia gravis with MRI evidence of early muscle atrophy

2012 ◽  
Vol 19 (6) ◽  
pp. 918-919 ◽  
Author(s):  
Vasiliki Zouvelou ◽  
Michael Rentzos ◽  
Panagiotis Toulas ◽  
Ioannis Evdokimidis
Keyword(s):  
Myasthenia Gravis ◽  
Muscle Atrophy

T.O.4 Ribozyme-based gene therapy reverses muscle atrophy in a mouse model of myotonic dystrophy

2007 ◽  
Vol 17 (9-10) ◽  
pp. 899 ◽  
Author(s):  
G. Doucet ◽  
A. Vignaud ◽  
G. Gourdon ◽  
A. Ferry ◽  
D. Furling ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Myotonic Dystrophy ◽  
Muscle Atrophy

MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears

2012 ◽  
Vol 31 (3) ◽  
pp. 421-426 ◽  
Author(s):  
Sanjum P. Samagh ◽  
Erik J. Kramer ◽  
Gerd Melkus ◽  
Dominique Laron ◽  
Blake M. Bodendorfer ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Fatty Infiltration ◽  
Rotator Cuff Tears

scholarly journals Neurogenic muscle atrophy in myasthenia gravis

1972 ◽  
Vol 35 (3) ◽  
pp. 311-322 ◽  
Author(s):  
B. Brownell ◽  
D. R. Oppenheimer ◽  
J. M. K. Spalding
Keyword(s):  
Myasthenia Gravis ◽  
Muscle Atrophy
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