scholarly journals In Vitro Activity of the Antifungal Azoles Itraconazole and Posaconazole against Leishmania amazonensis

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83247 ◽  
Author(s):  
Sara Teixeira de Macedo-Silva ◽  
Julio A. Urbina ◽  
Wanderley de Souza ◽  
Juliany Cola Fernandes Rodrigues
Keyword(s):  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity evaluation of seven Brazilian Asteraceae against cancer cells and Leishmania amazonensis

2019 ◽  
Vol 121 ◽  
pp. 267-273 ◽  
Author(s):  
Ana Cláudia Nogueira da Silva ◽  
Renato Malveira Carreiro do Nascimento ◽  
Débora Caroline do Nascimento Rodrigues ◽  
Paulo Michel Pinheiro Ferreira ◽  
Cláudia Pessoa ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Activity Evaluation

scholarly journals In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania) amazonensis

2014 ◽  
Vol 109 (8) ◽  
pp. 1050-1056 ◽  
Author(s):  
Yasmin Silva Rizk ◽  
Alice Fischer ◽  
Marillin de Castro Cunha ◽  
Patrik Oening Rodrigues ◽  
Maria Carolina Silva Marques ◽  
...  
Keyword(s):  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Hydroethanolic Extract

scholarly journals In vitro activity of chlorophyll A and B in Photodynamic Therapy on Leishmania (Leishmania) amazonensis

2018 ◽  
Vol 73 ◽  
pp. 299
Author(s):  
L.D.S. Braga ◽  
D.S.S.L. Lera ◽  
Á. C. F.H.R. Milaré ◽  
W. Caetano ◽  
S.M.A. Aristides ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chlorophyll A ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Chlorophyll A And B

In vitro activity of the essential oil of Cymbopogon citratus and its major component (citral) on Leishmania amazonensis

2009 ◽  
Vol 105 (6) ◽  
pp. 1489-1496 ◽  
Author(s):  
Marta Regina Santin ◽  
Adriana Oliveira dos Santos ◽  
Celso Vataru Nakamura ◽  
Benedito Prado Dias Filho ◽  
Izabel Cristina Piloto Ferreira ◽  
...  
Keyword(s):  
Essential Oil ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Cymbopogon Citratus

In vitro and in silico Activity of Iridoids Against Leishmania amazonensis

2019 ◽  
Vol 16 (2) ◽  
pp. 173-183
Author(s):  
Maria Helena Vendruscolo ◽  
Gustavo Machado das Neves ◽  
Luciano Porto Kagami ◽  
Luiz Carlos Rodrigues Junior ◽  
Maria Luísa Nunes Diehl ◽  
...  
Keyword(s):  
Natural Products ◽  
In Silico ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Leishmanicidal Activity ◽  
Leishmania Spp ◽  
Pharmacophoric Model ◽  
Molecular Modeling Studies

Background: Leishmaniasis reaches millions of people around the world. The control of the disease is difficult due to the restricted access to the diagnosis and medication, and low adherence to the treatment. Thus, more efficient drugs are needed and natural products are good alternatives. Iridoids, natural products with reported leishmanicidal activity, can be exploited for the development of anti- Leishmania drugs. The aim of this study was to isolate and to investigate the in vitro activity of iridoids against Leishmania amazonensis and to compare the activity in silico of these compounds with those reported as active against this parasite. Methods: Iridoids were isolated by chromatographic methods. The in vitro activity of asperuloside (1) and geniposide (2) from Escalonia bifida, galiridoside (3) from Angelonia integerrima and theveridoside (4) and ipolamiide (5) from Amphilophium crucigerum was investigated against promastigote forms of Leishmania amazonensis. Molecular modeling studies of 1-5 and iridoids cited as active against Leishmania spp. were performed. Results: Compounds 1-5 (5-100 µM) did not inhibit the parasite survival. Physicochemical parameters predicted for 1-5 did not show differences compared to those described in literature. The SAR and the pharmacophoric model confirmed the importance of maintaining the cyclopentane[C]pyran ring of the iridoid, of oxygen-linked substituents at the C1 and C6 positions and of bulky substituents attached to the iridoid ring to present leishmanicidal activity. Conclusion: The results obtained in this study indicate that iridoids are a promising group of secondary metabolites and should be further investigated in the search for new anti-Leishmania drugs.

scholarly journals Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Milene Aparecida Andrade ◽  
Clênia dos Santos Azevedo ◽  
Flávia Nader Motta ◽  
Maria Lucília dos Santos ◽  
Camila Lasse Silva ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity
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