scholarly journals Hepatitis B Virus Induces Cell Proliferation via HBx-Induced microRNA-21 in Hepatocellular Carcinoma by Targeting Programmed Cell Death Protein4 (PDCD4) and Phosphatase and Tensin Homologue (PTEN)

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91745 ◽  
Author(s):  
Preeti Damania ◽  
Bijoya Sen ◽  
Sadaf Bashir Dar ◽  
Satendra Kumar ◽  
Anupama Kumari ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Cell Death ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Programmed Cell Death ◽  
B Virus ◽  
Phosphatase And Tensin Homologue

scholarly journals The hepatitis B virus X gene induces p53-mediated programmed cell death

1997 ◽  
Vol 94 (15) ◽  
pp. 8162-8167 ◽  
Author(s):  
P. Chirillo ◽  
S. Pagano ◽  
G. Natoli ◽  
P. L. Puri ◽  
V. L. Burgio ◽  
...  
Keyword(s):  
Cell Death ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Programmed Cell Death ◽  
B Virus ◽  
X Gene

scholarly journals MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1

RSC Advances ◽  
2019 ◽  
Vol 9 (68) ◽  
pp. 39904-39913
Author(s):  
Fei Tang ◽  
Fengmei Wang ◽  
Hongmin Lv ◽  
Huiling Xiang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
B Virus ◽  
Proliferation And Apoptosis ◽  
Hcc Cells

MiR-1271 suppressed HBV-related HCC cells development by downregulating SIRT1.

miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma

2011 ◽  
Vol 411 (3) ◽  
pp. 586-592 ◽  
Author(s):  
Chun-Mei Wang ◽  
Yan Wang ◽  
Chun-Guang Fan ◽  
Fei-Fei Xu ◽  
Wen-Sheng Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
B Virus

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis

2014 ◽  
Vol 92 (2) ◽  
pp. 152-162 ◽  
Author(s):  
Yanrui Sheng ◽  
Shijia Ding ◽  
Ke Chen ◽  
Juan Chen ◽  
Sen Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Promoter Activity ◽  
Down Regulation ◽  
B Virus ◽  
And Migration ◽  
Hcc Cells ◽  
Proliferation And Migration

MicroRNA-101(miR-101) has been shown to be down-regulated in hepatocellular carcinoma (HCC). The hepatitis B virus (HBV) is a major risk factor in the development and progression of HCC. However, the correlation between HBV and miR-101 has not yet been fully elucidated. In this study, we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b. Dual-luciferase reporter assays showed that HBV down-regulated miR-101-3p by inhibiting its promoter activity. Down-regulation of miR-101-3p promoted cell proliferation, migration, and reduced apoptosis, and resulted in up-regulation of Rap1b, while overexpression of miR-101-3p inhibited these processes. Moreover, overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p. Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity, which resulted in up-regulation of Rap1b, and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells. This provides a new understanding of the mechanism of HBV-related HCC pathogenesis and the potential application of miR-101-3p in cancer therapy.

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