scholarly journals Suppression of Akt-mTOR Pathway-A Novel Component of Oncogene Induced DNA Damage Response Barrier in Breast Tumorigenesis

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97076 ◽  
Author(s):  
Anjana Bhardwaj ◽  
Daniel Rosen ◽  
Mei Liu ◽  
Yan Liu ◽  
Qiang Hao ◽  
...  
Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 305
Author(s):  
John-Patrick Alao ◽  
Luc Legon ◽  
Charalampos Rallis

Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular processes such as gene transcription, protein translation, autophagy, and metabolism, and is directly implicated in cellular and organismal aging as well as age-related diseases. mTOR mediates these processes in response to a broad range of inputs such as oxygen, amino acids, hormones, and energy levels, as well as stresses, including DNA damage. Here, we briefly summarize data relating to the interplays of the mTOR pathway with DNA damage response pathways in fission yeast, a favorite model in cell biology, and how these interactions shape cell decisions, growth, and cell-cycle progression. We, especially, comment on the roles of caffeine-mediated DNA-damage override. Understanding the biology of nutrient response, DNA damage and related pharmacological treatments can lead to the design of interventions towards improved cellular and organismal fitness, health, and survival.


DNA Repair ◽  
2021 ◽  
pp. 103142
Author(s):  
Romina Danesh Pazhooh ◽  
Parnia Rahnamay Farnood ◽  
Zatollah Asemi ◽  
Liaosadat Mirsafaei ◽  
Bahman Yousefi ◽  
...  

2013 ◽  
Author(s):  
Anjana Bhardwaj ◽  
Mei Liu ◽  
Yan Liu ◽  
Nivetha Ganesan ◽  
Daniel Rosen ◽  
...  

2021 ◽  
Vol 1875 (1) ◽  
pp. 188482
Author(s):  
Arathi Rajan ◽  
Revathy Nadhan ◽  
Neetha Rajan Latha ◽  
Neethu Krishnan ◽  
Arathy V. Warrier ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK

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