scholarly journals Prognostic Significance of Combination of Preoperative Platelet Count and Neutrophil-Lymphocyte Ratio (COP-NLR) in Patients with Non-Small Cell Lung Cancer: Based on a Large Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126496 ◽  
Author(s):  
Hua Zhang ◽  
Lianmin Zhang ◽  
Kaikai Zhu ◽  
Bowen Shi ◽  
Yuesong Yin ◽  
...  
2020 ◽  
Vol 9 (3) ◽  
pp. LMT37
Author(s):  
Bernardo L Rapoport ◽  
Annette J Theron ◽  
Daniel A Vorobiof ◽  
Lizanne Langenhoven ◽  
Jacqueline M Hall ◽  
...  

Aim: We investigated the prognostic potential of pretherapy measurement of the neutrophil/lymphocyte ratio (NLR) in patients (n = 56) with non-small-cell lung cancer deemed suitable for treatment with nivolumab. Materials & methods: This was a multicenter, noninterventional, retrospective data analysis, involving five oncology centers. Results: Patients with prenivolumab NLR values of <5 and ≥5 had respective median overall survival (OS) values of 14.5 and 7.02 months (p = 0.0026). Patients with ≤2 and >2 metastatic sites had median OS values of 11.4 and 6.1 months, respectively (p = 0.0174). A Cox multiple regression model revealed baseline NLR ≥5 as the only variable significantly associated with decreased OS (p < 0.0447). Conclusion: Pretreatment elevated NLR values are associated with poor outcomes in patients with recurrent metastatic non-small-cell lung cancer treated with nivolumab.


2020 ◽  
Vol 32 (4) ◽  
pp. 1046-1055 ◽  
Author(s):  
Satoru Okada ◽  
Masanori Shimomura ◽  
Hiroaki Tsunezuka ◽  
Satoshi Teramukai ◽  
Shunta Ishihara ◽  
...  

2018 ◽  
Author(s):  
Arutha Kulasinghe ◽  
Joanna Kapeleris ◽  
Rebecca Kimberley ◽  
Stephen R Mattarollo ◽  
Erik W Thompson ◽  
...  

2021 ◽  
Vol 16 (3) ◽  
pp. S569
Author(s):  
M. Vanderputten ◽  
F. Aboubakar ◽  
C. Bouzin ◽  
D. Hoton ◽  
C. Stanciu Pop ◽  
...  

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