scholarly journals Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133055 ◽  
Author(s):  
Na Yu ◽  
Zhang Zhang ◽  
Pei Chen ◽  
Yimin Zhong ◽  
Xiaoxiao Cai ◽  
...  
Keyword(s):  
Active Ingredient ◽  
Trabecular Meshwork ◽  
Chinese Herb ◽  
Cxcr4 Axis ◽  
Herb Medicine ◽  
Chinese Herb Medicine

Anti-Inflammatory Function of Nodosin via Inhibition of IL-2

2010 ◽  
Vol 38 (01) ◽  
pp. 127-142 ◽  
Author(s):  
Jiyu Li ◽  
Junming Du ◽  
Lijuan Sun ◽  
Jianwen Liu ◽  
Zhiwei Quan
Keyword(s):  
Clinical Trial ◽  
T Lymphocytes ◽  
Mrna Level ◽  
Chinese Herb ◽  
Potential Candidate ◽  
Traditional Chinese Herb ◽  
Anti Inflammatory ◽  
Cell Mitosis ◽  
Herb Medicine ◽  
Chinese Herb Medicine

In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.

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