scholarly journals Prognosis Biomarkers of Severe Sepsis and Septic Shock by 1H NMR Urine Metabolomics in the Intensive Care Unit

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0140993 ◽  
Author(s):  
Monica Garcia-Simon ◽  
Jose M. Morales ◽  
Vicente Modesto-Alapont ◽  
Vannina Gonzalez-Marrachelli ◽  
Rosa Vento-Rehues ◽  
...  
2020 ◽  
Author(s):  
Steven P LaRosa ◽  
Steven M. Opal

Sepsis, along with the multiorgan failure that often accompanies this condition, is a leading cause of mortality in the intensive care unit. Although modest improvements in the prognosis have been made over the past two decades and promising new therapies continue to be investigated, innovations in the management of septic shock are still required. This chapter discusses the definitions, epidemiology, and pathogenesis (including microbial factors, host-derived mediators, and organ dysfunction) relating to sepsis. Management of severe sepsis and septic shock is also described.  This review contains 5 figures, 11 tables, and 99 references. Keywords:Organ dysfunction, sepsis, septic shock, infection, bacteremia, fluid resuscitation, vasopressor


This case focuses on detecting sepsis through early goal-directed therapies by asking the question: Does aggressive correction of hemodynamic disturbances in the early stages of sepsis improve outcomes? Early goal-directed therapies are aimed at restoring a balance between oxygen delivery and oxygen demand. Patients included in the study were adults presenting to the emergency room with severe sepsis or septic shock. Study results indicated that most patients with severe sepsis or septic shock should be managed with aggressive hemodynamic monitoring and support immediately on presentation in the emergency department (or, if this is not possible, in the intensive care unit) for 6 hours or until there is resolution of hemodynamic disturbances.


2012 ◽  
Vol 27 (4) ◽  
pp. 394-399 ◽  
Author(s):  
Carlos Adolfo Merino ◽  
Felipe Tomás Martínez ◽  
Felipe Cardemil ◽  
José Ramón Rodríguez

2015 ◽  
Vol 47 (8) ◽  
pp. 584-587 ◽  
Author(s):  
Kevin Ng ◽  
Christa Schorr ◽  
Annette C. Reboli ◽  
Sergio Zanotti ◽  
Constantine Tsigrelis

2020 ◽  
Author(s):  
Steven P LaRosa ◽  
Steven M. Opal

Sepsis, along with the multiorgan failure that often accompanies this condition, is a leading cause of mortality in the intensive care unit. Although modest improvements in the prognosis have been made over the past two decades and promising new therapies continue to be investigated, innovations in the management of septic shock are still required. This chapter discusses the definitions, epidemiology, and pathogenesis (including microbial factors, host-derived mediators, and organ dysfunction) relating to sepsis. Management of severe sepsis and septic shock is also described.  This review contains 5 figures, 11 tables, and 99 references. Keywords:Organ dysfunction, sepsis, septic shock, infection, bacteremia, fluid resuscitation, vasopressor


Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 4) ◽  
pp. P39 ◽  
Author(s):  
Spyridon Pactitis ◽  
Grammati Koutra ◽  
Charalambos Charalambidis ◽  
Zoi Psomadaki ◽  
Athanasia Karouzou ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document