scholarly journals High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144603 ◽  
Author(s):  
Ho-Chang Kuo ◽  
Mao-Hung Lo ◽  
Kai-Sheng Hsieh ◽  
Mindy Ming-Huey Guo ◽  
Ying-Hsien Huang
Keyword(s):  
Kawasaki Disease ◽  
High Dose ◽  
Disease Outcomes ◽  
Dose Aspirin ◽  
High Dose Aspirin

scholarly journals Kawasaki Disease Presenting as Acute Acalculous Cholecystitis

2019 ◽  
Vol 3 (4) ◽  
pp. 383-386 ◽  
Author(s):  
Demis Lipe ◽  
Lindsey Bridges
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
High Dose ◽  
Coronary Artery Aneurysms ◽  
Abdominal Symptoms ◽  
Dose Aspirin ◽  
Serious Disease ◽  
High Dose Aspirin

Acute acalculous cholecystitis (AAC) is a rare, potentially serious disease that has been associated with Kawasaki disease (KD) in children. Studies suggest that patients presenting with severe abdominal symptoms secondary to KD have increased resistance to intravenous immunoglobulin (IVIG), and a higher rate of coronary artery aneurysms. We describe an eight-year-old boy who presented to the emergency department with severe abdominal pain and was diagnosed with AAC and KD. He was treated with IVIG and high-dose aspirin, achieving good response with complete symptom resolution. He had no coronary artery aneurysms or further complications and was discharged after three days.

scholarly journals What dose of aspirin should be used in the initial treatment of Kawasaki disease? A meta-analysis

Rheumatology ◽  
2020 ◽  
Vol 59 (8) ◽  
pp. 1826-1833
Author(s):  
Xinyi Jia ◽  
Xiao Du ◽  
Shuxian Bie ◽  
Xiaobing Li ◽  
Yunguang Bao ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Random Effects ◽  
Initial Treatment ◽  
Low Dose ◽  
Cochrane Library ◽  
High Dose ◽  
Random Effects Model ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
High Dose Aspirin

Abstract Objective The use of IVIG plus high- or low-dose aspirin for the initial treatment of Kawasaki disease remains controversial. The aim of this study was to evaluate the efficacy of IVIG plus high-dose aspirin compared with IVIG plus low-dose aspirin in the treatment of Kawasaki disease. Methods Studies related to aspirin therapy for Kawasaki disease were selected by searching the databases of Medline (PubMed), Embase and the Cochrane Library before March 2019. Statistical analyses were performed by using a Review Manager Software package and STATA v.15.1. Results Eight retrospective cohort studies, characterizing 12 176 patients, were analysed. Overall, no significant difference was found in the incidence of coronary artery abnormalities between the high- and low-dose aspirin groups [relative risk (RR) 1.15; 95% CI: 0.93, 1.43; P = 0.19; random-effects model]. The patients treated with high-dose aspirin had slightly faster resolution of fever [mean difference (MD) −0.30; 95% CI: −0.58, −0.02; P = 0.04; random-effects model]. but the rates of IVIG resistance (RR, 1.26; 95% CI: 0.55, 2.92; P = 0.59; random-effects model) and days in hospital (MD, 0.22; 95% CI: −0.93, 1.37; P = 0.71; random-effects model) were similar between the two groups. Conclusion Low-dose aspirin plus IVIG might be as effective as high-dose aspirin plus IVIG for the initial treatment of Kawasaki disease. Considering that high-dose aspirin may cause more adverse reactions than low-dose aspirin, low-dose aspirin plus IVIG should be recommended as the first-line therapy in the initial treatment of Kawasaki disease.

scholarly journals Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease

2018 ◽  
Vol 83 (6) ◽  
pp. 1136-1145 ◽  
Author(s):  
Karl Migally ◽  
Elizabeth A Braunlin ◽  
Lei Zhang ◽  
Bryce A Binstadt
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Aspirin Therapy ◽  
High Dose ◽  
Dose Aspirin ◽  
High Dose Aspirin

scholarly journals Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin

2020 ◽  
Vol 3 (1) ◽  
pp. e1918565 ◽  
Author(s):  
Brooks Platt ◽  
Emily Belarski ◽  
John Manaloor ◽  
Susan Ofner ◽  
Aaron E. Carroll ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Low Dose ◽  
High Dose ◽  
Dose Aspirin ◽  
High Dose Aspirin

scholarly journals Efficacy between low and high dose aspirin for the initial treatment of Kawasaki disease: Current evidence based on a meta-analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0217274 ◽  
Author(s):  
Xiaolan Zheng ◽  
Peng Yue ◽  
Lei Liu ◽  
Changqing Tang ◽  
Fan Ma ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Initial Treatment ◽  
Meta Analysis ◽  
Current Evidence ◽  
High Dose ◽  
Evidence Based ◽  
Dose Aspirin ◽  
High Dose Aspirin

scholarly journals Atypical Kawasaki Disease in a 4 Years Old Child with Mumps

2018 ◽  
Vol 56 (212) ◽  
pp. 811-814
Author(s):  
Prakash Banjade ◽  
Karan Subedi
Keyword(s):  
Kawasaki Disease ◽  
Cardiac Disease ◽  
High Dose ◽  
Incomplete Kawasaki Disease ◽  
Cervical Adenitis ◽  
Dose Aspirin ◽  
Febrile Condition ◽  
Viral Illness ◽  
Atypical Kawasaki Disease ◽  
High Dose Aspirin

Kawasaki disease is an acute febrile condition seen in children. However, it is also well recognized that some patients do not fulfill the classic diagnostic criteria for the diagnosis of Kawasaki disease. The incomplete form of Kawasaki disease is termed as ‘Incomplete KD’ or ‘Atypical KD’. This is a case of 4 years old child with fever and mumps. He had bilateral cervical adenitis. Patient failed to respond to IV antibiotics fulfilled the criteria of incomplete Kawasaki disease. The child was managed with high dose aspirin until the child was afebrile for 48 hours. Kawasaki disease is a common vasculitis in children. Atypical cases might be missed if there is concomitant viral illness. Hence the identification and management of Kawasaki disease is paramount to decrease the mortality related to the cardiac disease.

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