scholarly journals Comparative Study between High Dose Aspirin and Ibuprofen in the Treatment of Kawasaki Disease in the Acute Stage

2018 ◽  
Vol 24 (2) ◽  
pp. 175-180
Author(s):  
Seung Ju Lee ◽  
Gyeong Hee Yoo
Keyword(s):  
Kawasaki Disease ◽  
Comparative Study ◽  
Acute Stage ◽  
High Dose ◽  
Dose Aspirin ◽  
High Dose Aspirin

scholarly journals Kawasaki Disease Presenting as Acute Acalculous Cholecystitis

2019 ◽  
Vol 3 (4) ◽  
pp. 383-386 ◽  
Author(s):  
Demis Lipe ◽  
Lindsey Bridges
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
High Dose ◽  
Coronary Artery Aneurysms ◽  
Abdominal Symptoms ◽  
Dose Aspirin ◽  
Serious Disease ◽  
High Dose Aspirin

Acute acalculous cholecystitis (AAC) is a rare, potentially serious disease that has been associated with Kawasaki disease (KD) in children. Studies suggest that patients presenting with severe abdominal symptoms secondary to KD have increased resistance to intravenous immunoglobulin (IVIG), and a higher rate of coronary artery aneurysms. We describe an eight-year-old boy who presented to the emergency department with severe abdominal pain and was diagnosed with AAC and KD. He was treated with IVIG and high-dose aspirin, achieving good response with complete symptom resolution. He had no coronary artery aneurysms or further complications and was discharged after three days.

scholarly journals What dose of aspirin should be used in the initial treatment of Kawasaki disease? A meta-analysis

Rheumatology ◽  
2020 ◽  
Vol 59 (8) ◽  
pp. 1826-1833
Author(s):  
Xinyi Jia ◽  
Xiao Du ◽  
Shuxian Bie ◽  
Xiaobing Li ◽  
Yunguang Bao ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Random Effects ◽  
Initial Treatment ◽  
Low Dose ◽  
Cochrane Library ◽  
High Dose ◽  
Random Effects Model ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
High Dose Aspirin

Abstract Objective The use of IVIG plus high- or low-dose aspirin for the initial treatment of Kawasaki disease remains controversial. The aim of this study was to evaluate the efficacy of IVIG plus high-dose aspirin compared with IVIG plus low-dose aspirin in the treatment of Kawasaki disease. Methods Studies related to aspirin therapy for Kawasaki disease were selected by searching the databases of Medline (PubMed), Embase and the Cochrane Library before March 2019. Statistical analyses were performed by using a Review Manager Software package and STATA v.15.1. Results Eight retrospective cohort studies, characterizing 12 176 patients, were analysed. Overall, no significant difference was found in the incidence of coronary artery abnormalities between the high- and low-dose aspirin groups [relative risk (RR) 1.15; 95% CI: 0.93, 1.43; P = 0.19; random-effects model]. The patients treated with high-dose aspirin had slightly faster resolution of fever [mean difference (MD) −0.30; 95% CI: −0.58, −0.02; P = 0.04; random-effects model]. but the rates of IVIG resistance (RR, 1.26; 95% CI: 0.55, 2.92; P = 0.59; random-effects model) and days in hospital (MD, 0.22; 95% CI: −0.93, 1.37; P = 0.71; random-effects model) were similar between the two groups. Conclusion Low-dose aspirin plus IVIG might be as effective as high-dose aspirin plus IVIG for the initial treatment of Kawasaki disease. Considering that high-dose aspirin may cause more adverse reactions than low-dose aspirin, low-dose aspirin plus IVIG should be recommended as the first-line therapy in the initial treatment of Kawasaki disease.

scholarly journals High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144603 ◽  
Author(s):  
Ho-Chang Kuo ◽  
Mao-Hung Lo ◽  
Kai-Sheng Hsieh ◽  
Mindy Ming-Huey Guo ◽  
Ying-Hsien Huang
Keyword(s):  
Kawasaki Disease ◽  
High Dose ◽  
Disease Outcomes ◽  
Dose Aspirin ◽  
High Dose Aspirin

Coronary Artery Involvement in Kawasaki Syndrome in Manhattan, New York: Risk Factors and Role of Aspirin

PEDIATRICS ◽  
1987 ◽  
Vol 80 (6) ◽  
pp. 828-835 ◽  
Author(s):  
Fukiko Ichida ◽  
Nunzia S. Fatica ◽  
Mary Allen Engle ◽  
John E. O'Loughlin ◽  
Arthur A. Klein ◽  
...  
Keyword(s):  
Risk Factors ◽  
Age At Onset ◽  
Acute Stage ◽  
Kawasaki Syndrome ◽  
High Dose ◽  
Female Ratio ◽  
Dose Aspirin ◽  
Significant Difference ◽  
Coronary Abnormality ◽  
High Dose Aspirin

Since January 1980, 110 children having 113 attacks of Kawasaki syndrome were studied. Age at onset was 7 weeks to 12 years (mean 36/12 years, median 29/12 years); 77% were younger than 5 years of age; the male to female ratio was 1.8; racial distribution was 52% white, 19% black, 14% Hispanic, and 16% Asian. Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. Two-dimensional echocardiograms were done weekly during the acute stage, at 2 and 6 months after onset, and yearly if a coronary abnormality was detected. At 1 month, 51 coronary arterial abnormalities were present in 25 patients. Risk factors for a coronary abnormality were duration of fever greater than or equal to 2 weeks, level of platelet count, marked elevation of ESR, and age younger than 5 years. No statistically significant difference in incidence of aneurysms was detected between patients on high-dose aspirin and those on medium- or low-dose aspirin.

Abstract 18815: High Dose Aspirin is Associated With Decrease of Hemoglobin and Do Not Affect the Disease Outcome in Acute Stage of Kawasaki Disease

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Ho-Chang Kuo ◽  
Kai-Sheng Hsieh
Keyword(s):  
Acute Phase ◽  
Acute Stage ◽  
Ivig Treatment ◽  
High Dose ◽  
Dose Aspirin ◽  
Significant Difference ◽  
Serum Hepcidin ◽  
Group 2 ◽  
High Dose Aspirin ◽  
Group 1

Introduction: Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. Although intravenous immunoglobulin (IVIG) has been shown to reduce the incidence of coronary artery lesions (CAL) effectively, the role and appropriate dose of aspirin during acute phase is still unclear. Thus, this study was conducted to evaluate the effect of treatment and the change of serum hepcidin with or without high dose aspirin in the acute stage of KD. Hypothesis: High dose aspirin is not benefit for acute stage of KD. Methods: Retrospective analysis of KD patients from two medical centers during 1999-2009 in Taiwan. All patients were initially treated with a single dose of IVIG (2 g/kg) during a 12-h period. High dose aspirin was given (> 50 mg/kg/day) until the fever subsided then low-dose aspirin (3-5 mg/kg/day) was prescribed until all signs of inflammation resolved at group 1. Low-dose aspirin was prescribed without high-dose aspirin at group 2. A total of 851 KD patients (group 1, N= 305, group 2, N= 546) were enrolled in this study. patients. Results: There were no significant difference between group 1 and group 2 including gender distribution (p=0.51), IVIG resistant rate (31/305 vs. 38/546, p=0.07), CAL formation rate (52/305 vs. 84/546, p=0.67), and total hospital days (6.3 ± 0.2 vs. 6.7 ± 0.2, p=0.13). There were also no significant difference between total white blood counts, hemoglobin levels, platelet counts, CRP and serum hepcidin levels before IVIG treatment between group 1 and group 2 (all p>0.1). After IVIG treatment, there were significant lower hemoglobin and higher CRP as well as lower decrease of CRP levels in group 1 than in group 2 (p=0.006, <0.001 and =0.012, respectively). Furthermore, there were also high serum hepcidin and lower decrease of hepcidin levels in group 1 than in group 2 (p=0.04, and =0.02, respectively). Conclusions: These results provide evidence supporting high dose aspirin in acute phase of KD may affect the improvement of inflammatory markers. It also caused lower hemoglobin level that was associated with higher hepcidin level after IVIG treatment. It seems unneeded of high dose aspirin in acute phase of KD.

scholarly journals Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease

2018 ◽  
Vol 83 (6) ◽  
pp. 1136-1145 ◽  
Author(s):  
Karl Migally ◽  
Elizabeth A Braunlin ◽  
Lei Zhang ◽  
Bryce A Binstadt
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Aspirin Therapy ◽  
High Dose ◽  
Dose Aspirin ◽  
High Dose Aspirin
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