scholarly journals Effects of mesenchymal stromal cell-conditioned media on measures of lung structure and function: a systematic review and meta-analysis of preclinical studies

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alvaro Moreira ◽  
Rija Naqvi ◽  
Kristen Hall ◽  
Chimobi Emukah ◽  
John Martinez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Lung Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Lung ◽  
Meta Analysis ◽  
Structure And Function ◽  
Lung Structure ◽  
And Function

Abstract Background Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is part two of our previous work. In part 1, we demonstrated that CdM is as effective as MSCs in modulating inflammation. Herein, we investigated the effects of mesenchymal stromal cell (MSC)-conditioned media (CdM) on (i) lung architecture/function in animal models mimicking human lung disease, and (ii) performed a head-to-head comparison of CdM to MSCs. Methods Adhering to the animal Systematic Review Centre for Laboratory animal Experimentation protocol, we conducted a search of English articles in five medical databases. Two independent investigators collected information regarding lung: alveolarization, vasculogenesis, permeability, histologic injury, compliance, and measures of right ventricular hypertrophy and right pulmonary pressure. Meta-analysis was performed to generate random effect size using standardized mean difference with 95% confidence interval. Results A total of 29 studies met inclusion. Lung diseases included bronchopulmonary dysplasia, asthma, pulmonary hypertension, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. CdM improved all measures of lung structure and function. Moreover, no statistical difference was observed in any of the lung measures between MSCs and CdM. Conclusions In this meta-analysis of animal models recapitulating human lung disease, CdM improved lung structure and function and had an effect size comparable to MSCs.

The aging lung

1999 ◽  
Vol 9 (2) ◽  
pp. 103-115 ◽  
Author(s):  
Christopher AE Dyer ◽  
Robert A Stockley
Keyword(s):  
Lung Disease ◽  
Elderly People ◽  
Human Lung ◽  
Environmental Pollutants ◽  
Tobacco Consumption ◽  
Structure And Function ◽  
Lung Structure ◽  
Pulmonary Changes ◽  
And Function ◽  
Disease Exposure

Over a lifetime, the human lung is exposed to a multitude of factors capable of altering its structure and function. The frequency of acute, self-limiting lung disease, exposure to environmental pollutants and previous tobacco consumption in elderly people makes it difficult to identify pulmonary changes that can be attributed to ‘normal aging’ alone. It is likely that all these factors may have some influence on both lung structure and function.

scholarly journals A Systematic Review of the Influence of Continuous Positive Airway Pressure on Fetal and Newborn Animal Models: Suggestions to Improve Neonatal Respiratory Care

Neonatology ◽  
2020 ◽  
Vol 118 (1) ◽  
pp. 5-14
Author(s):  
Andre George Gie ◽  
Talia Rose Hubble ◽  
Yannick Regin ◽  
Thomas Salaets ◽  
Monica Zamora ◽  
...  
Keyword(s):  
Systematic Review ◽  
Continuous Positive Airway Pressure ◽  
Animal Models ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Structure And Function ◽  
Newborn Animal ◽  
Lung Structure ◽  
Surfactant Administration ◽  
And Function

<b><i>Introduction:</i></b> Prematurely born infants regularly develop respiratory distress syndrome and require assisted ventilation. Ventilation may injure the premature lung and increase the risk of bronchopulmonary dysplasia. Continuous positive airway pressure (CPAP), a form of noninvasive ventilation, is commonly used in modern neonatology. Limited clinical data are available on the acute and long-term effect of neonatal exposure to CPAP on the lung. Given the restricted clinical data, newborn animal models have been used to study the influence of CPAP on lung structure and function. The findings of animal studies can guide neonatal care and improve the use of CPAP. <b><i>Methods:</i></b> A systematic review of electronic databases (Medline, Embase, and Cinahl) was performed using the medical subject heading terms, “CPAP” or “continuous positive airway pressure” and “animals” and “newborn.” Abstracts were screened for inclusion using predetermined eligibility criteria. <b><i>Results:</i></b> In total, 235 abstracts were identified and screened for inclusion. Of these, 21 papers were included. Large (<i>N</i> = 18) and small (<i>N</i> = 3) animal models investigated the effects of CPAP. Pulmonary outcomes included gas exchange, lung structure and function, surfactant metabolism, lung inflammation and injury, and the effect of intrapulmonary therapy. Compared to mechanical ventilation, CPAP improves lung function, evokes less lung injury, and does not disrupt alveolar development. Surfactant administration combined with CPAP further improves respiratory outcomes. Of concern are findings that CPAP may increase airway reactivity. <b><i>Discussion/Conclusion:</i></b> CPAP offers numerous advantages over mechanical ventilation for the immature lung. The combination of CPAP and exogenous surfactant administration offers further pulmonary benefit.

scholarly journals Mesenchymal stromal cell conditioned media for lung disease: a systematic review and meta-analysis of preclinical studies

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Chimobi Emukah ◽  
Evan Dittmar ◽  
Rija Naqvi ◽  
John Martinez ◽  
Alexis Corral ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Hypertension ◽  
Lung Disease ◽  
Effect Size ◽  
Mesenchymal Stromal Cell ◽  
Lung Diseases ◽  
Stromal Cell ◽  
Meta Analysis ◽  
Inflammatory Cells ◽  
Preclinical Studies

Abstract Background Inflammation plays an important role in the pathogenesis of many lung diseases. Preclinical studies suggest that mesenchymal stromal cell (MSC) conditioned media (CdM) can attenuate inflammation. Our aim was threefold: (1) summarize the existing animal literature evaluating CdM as a therapeutic agent for pediatric/adult lung disease, (2) quantify the effects of CdM on inflammation, and (3) compare inflammatory effects of CdM to MSCs. Methods Adhering to the Systematic Review Protocol for Animal Intervention Studies, a systematic search of English articles was performed in five databases. Meta-analysis and meta-regression were performed to generate random effect size using standardized mean difference (SMD). Results A total of 10 studies met inclusion. Lung diseases included bronchopulmonary dysplasia, asthma, pulmonary hypertension, and acute respiratory distress syndrome. CdM decreased inflammatory cells (1.02 SMD, 95% CI 0.86, 1.18) and cytokines (0.71 SMD, 95% CI 0.59, 0.84). The strongest effect for inflammatory cells was in bronchopulmonary dysplasia (3.74 SMD, 95% CI 3.13, 4.36) while pulmonary hypertension had the greatest reduction in inflammatory cytokine expression (1.44 SMD, 95% CI 1.18, 1.71). Overall, CdM and MSCs had similar anti-inflammatory effects. Conclusions In this meta-analysis of animal models recapitulating lung disease, CdM improved inflammation and had an effect size comparable to MSCs. While these findings are encouraging, the risk of bias and heterogeneity limited the strength of our findings.

scholarly journals Electromyogram-Related Neuromuscular Electrical Stimulation for Restoring Wrist and Hand Movement in Poststroke Hemiplegia: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 33 (2) ◽  
pp. 96-111 ◽  
Author(s):  
Katia Monte-Silva ◽  
Daniele Piscitelli ◽  
Nahid Norouzi-Gheidari ◽  
Marc Aureli Pique Batalla ◽  
Philippe Archambault ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Electrical Stimulation ◽  
Meta Analysis ◽  
Neuromuscular Electrical Stimulation ◽  
Structure And Function ◽  
Motor Recovery ◽  
Body Structure ◽  
Short Term ◽  
And Function

Background. Clinical trials have demonstrated some benefits of electromyogram-triggered/controlled neuromuscular electrical stimulation (EMG-NMES) on motor recovery of upper limb (UL) function in patients with stroke. However, EMG-NMES use in clinical practice is limited due to a lack of evidence supporting its effectiveness. Objective. To perform a systematic review and meta-analysis to determine the effects of EMG-NMES on stroke UL recovery based on each of the International Classification of Functioning, Disability, and Health (ICF) domains. Methods. Database searches identified clinical trials comparing the effect of EMG-NMES versus no treatment or another treatment on stroke upper extremity motor recovery. A meta-analysis was done for outcomes at each ICF domain (Body Structure and Function, Activity and Participation) at posttest (short-term) and follow-up periods. Subgroup analyses were conducted based on stroke chronicity (acute/subacute, chronic phases). Sensitivity analysis was done by removing studies rated as poor or fair quality (PEDro score <6). Results. Twenty-six studies (782 patients) met the inclusion criteria. Fifty percent of them were considered to be of high quality. The meta-analysis showed that EMG-NMES has a robust short-term effect on improving UL motor impairment in the Body Structure and Function domain. No evidence was found in favor of EMG-NMES for the Activity and Participation domain. EMG-NMES had a stronger effect for each ICF domain in chronic (≥3 months) compared to acute/subacute phases. Conclusion. EMG-NMES is effective in the short term in improving UL impairment in individuals with chronic stroke.

scholarly journals Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147170 ◽  
Author(s):  
Lauralyn A. McIntyre ◽  
David Moher ◽  
Dean A. Fergusson ◽  
Katrina J. Sullivan ◽  
Shirley H. J. Mei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Preclinical Animal Models
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