scholarly journals Amplitude of low-frequency fluctuations in first-episode, drug-naïve depressive patients: A 5-year retrospective study

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174564 ◽  
Author(s):  
Kerang Zhang ◽  
Zhifen Liu ◽  
Xiaohua Cao ◽  
Chunxia Yang ◽  
Yong Xu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Low Frequency ◽  
First Episode ◽  
Drug Naïve ◽  
Frequency Fluctuations ◽  
Depressive Patients

scholarly journals Repeated use of SSRIs potentially associated with an increase on serum CK and CK-MB in patients with major depressive disorder: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shengwei Wu ◽  
Yufang Zhou ◽  
Zhengzheng Xuan ◽  
Linghui Xiong ◽  
Xinyu Ge ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Cardiac Injury ◽  
First Episode ◽  
Cardiovascular Risks ◽  
Major Depressive ◽  
Depressive Patients

AbstractThere is a large amount of evidence that selective serotonin reuptake inhibitors (SSRIs) are related to cardiovascular toxicity, which has aroused concern regarding their safety. However, few studies have evaluated the effects of SSRIs on cardiac injury biomarkers, such as creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether SSRIs elevated CK and CK-MB levels of prior medicated depressive patients (PMDP) compared to first-episode drug-naïve depressive patients (FDDPs). We performed an observational and retrospective study involving 128 patients with major depressive disorder. Patients who had never used any type of antidepressant were designated FDDP; patients who had used only one type of SSRI but were not treated after a recent relapse were designated PMDP. Serum CK and CK-MB levels were measured before and after using SSRIs for a period of time. The duration of current treatment in the FDDP and PMDP groups was 16.200 ± 16.726 weeks and 15.618 ± 16.902 weeks, respectively. After SSRI treatment, levels of serum CK in the PMDP group were significantly higher than in the FDDP group. Univariate ANCOVA results revealed that PMDP was 22.313 times more likely to elevate CK (OR 22.313, 95% CI 9.605–35.022) and 2.615 times more likely to elevate CK-MB (OR 2.615, 95% CI 1.287–3.943) than FDDP. Multivariate ANCOVA revealed an interaction between the group and sex of CK and CK-MB. Further pairwise analysis of the interaction results showed that in female patients, the mean difference (MD) of CK and CK-MB in PMDP was significantly greater than that in FDDP (MD = 33.410, P = 0.000, 95% CI 15.935–50.886; MD = 4.613, P = 0.000, 95% CI 2.846–6.381). Our findings suggest that patients, especially females, who had previously used SSRI antidepressants were more likely to have elevated CK and CK-MB, indicators of myocardial muscle injury. Use of SSRIs should not be assumed to be completely safe and without any cardiovascular risks.

scholarly journals Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Ruiping Zheng ◽  
Yuan Chen ◽  
Yu Jiang ◽  
Mengmeng Wen ◽  
Bingqian Zhou ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Neural Activity ◽  
Temporal Variability ◽  
Brain Activity ◽  
Low Frequency ◽  
First Episode ◽  
Posterior Lobe ◽  
Major Depressive ◽  
Drug Naïve ◽  
The Right

Background: Major depressive disorder (MDD) has demonstrated abnormalities of static intrinsic brain activity measured by amplitude of low-frequency fluctuation (ALFF). Recent studies regarding the resting-state functional magnetic resonance imaging (rs-fMRI) have found the brain activity is inherently dynamic over time. Little is known, however, regarding the temporal dynamics of local neural activity in MDD. Here, we investigated whether temporal dynamic changes in spontaneous neural activity are influenced by MDD.Methods: We recruited 81 first-episode, drug-naive MDD patients and 64 age-, gender-, and education-matched healthy controls who underwent rs-fMRI. A sliding-window approach was then adopted for the estimation of dynamic ALFF (dALFF), which was used to measure time-varying brain activity and then compared between the two groups. The relationship between altered dALFF variability and clinical variables in MDD patients was also analyzed.Results: MDD patients showed increased temporal variability (dALFF) mainly focused on the bilateral thalamus, the bilateral superior frontal gyrus, the right middle frontal gyrus, the bilateral cerebellum posterior lobe, and the vermis. Furthermore, increased dALFF variability values in the right thalamus and right cerebellum posterior lobe were positively correlated with MDD symptom severity.Conclusions: The overall results suggest that altered temporal variability in corticocerebellar–thalamic–cortical circuit (CCTCC), involved in emotional, executive, and cognitive, is associated with drug-naive, first-episode MDD patients. Moreover, our study highlights the vital role of abnormal dynamic brain activity in the cerebellar hemisphere associated with CCTCC in MDD patients. These findings may provide novel insights into the pathophysiological mechanisms of MDD.

scholarly journals Is there any difference in the fractional amplitude of low-frequency fluctuations between first episode major depressive disorder patients and subclinical depressive subjects?

2020 ◽  
Author(s):  
Fang Xie ◽  
Xiuhang Ruan ◽  
Guoqing Zhang ◽  
Yuting Li ◽  
E Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Visual Recognition ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Fusiform Gyrus ◽  
First Episode ◽  
Major Depressive ◽  
Frequency Fluctuations ◽  
The Right

Abstract Background To explore the differences in the fractional amplitude of low-frequency fluctuations (fALFF) at the whole-brain level between young adults with major depressive disorder (MDD) and those with Subclinical depression (SD). Methods Thirty-nine first-episode MDD patients, 30 SD subjects, and 37 healthy controls (HCs) were recruited. All participants underwent resting-state fMRI (Rs-fMRI) scans on a 3T MR scanner. We used the fALFF to explore spontaneous neuronal activity between groups. Results Significant differences in the fALFF were observed among the three groups. Compared with the HCs, an increased fALFF was found in the left cerebellum in MDD patients. When MDD patients were compared with SD subjects, we observed increased fALFF values in the bilateral fusiform gyrus and decreased fALFF values in the right inferior frontal gyrus, right superior frontal gyrus, right middle frontal gyrus, left cuneus and right precuneus. Compared with the HCs, the SD group demonstrated increased fALFF values in the precuneus. Additionally, a positive correlated was revealed between the fALFF values and Hamilton Anxiety Scale (HAMA)score in the right fusiform gyrus in MDD patients. Moreover, the fALFF value were negatively correlated with the Beck Depression Inventory (BDI) score in the right inferior frontal gyrus and with the age in the left fusiform gyrus in SD subjects. Conclusions Our findings suggest that alterations of cognitive and executive networks, default mode networks and visual recognition circuits may contribute to the different neural mechanisms between MDD and SD in young adult subjects.

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