scholarly journals A versatile cell-penetrating peptide-adaptor system for efficient delivery of molecular cargos to subcellular destinations

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0178648 ◽  
Author(s):  
Verra M. Ngwa ◽  
David S. Axford ◽  
Allison N. Healey ◽  
Scott J. Nowak ◽  
Carol A. Chrestensen ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Efficient Delivery ◽  
Cell Penetrating

scholarly journals A Cancer Specific Cell-Penetrating Peptide, BR2, for the Efficient Delivery of an scFv into Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66084 ◽  
Author(s):  
Ki Jung Lim ◽  
Bong Hyun Sung ◽  
Ju Ri Shin ◽  
Young Woong Lee ◽  
Da Jung Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Efficient Delivery ◽  
Cell Penetrating

ZEBRA cell-penetrating peptide as an efficient delivery system inCandida albicans

2014 ◽  
Vol 9 (8) ◽  
pp. 1088-1094 ◽  
Author(s):  
Roberta Marchione ◽  
David Daydé ◽  
Jean-Luc Lenormand ◽  
Muriel Cornet
Keyword(s):  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Efficient Delivery ◽  
Cell Penetrating ◽  
Incandida Albicans

Highly Efficient Delivery of Functional Cargoes by a Novel Cell-Penetrating Peptide Derived from SP140-Like Protein

2016 ◽  
Vol 27 (5) ◽  
pp. 1373-1381 ◽  
Author(s):  
Hu Wang ◽  
Jielan Ma ◽  
Yinggui Yang ◽  
Fanhui Zeng ◽  
Changbai Liu
Keyword(s):  
Cell Penetrating Peptide ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Cell Penetrating

scholarly journals A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids

2007 ◽  
Vol 15 (10) ◽  
pp. 1820-1826 ◽  
Author(s):  
Samir El-Andaloussi ◽  
Henrik J Johansson ◽  
Tina Holm ◽  
Ülo Langel
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Cell Penetrating Peptide ◽  
Efficient Delivery ◽  
Cell Penetrating

scholarly journals Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1046
Author(s):  
Safa Bazaz ◽  
Tõnis Lehto ◽  
Rahel Tops ◽  
Olof Gissberg ◽  
Dhanu Gupta ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Efficient Delivery ◽  
Cell Penetrating ◽  
Peptide Nanoparticles ◽  
Therapeutic Compounds ◽  
Peptide Stapling

Splice-switching therapy with splice-switching oligonucleotides (SSOs) has recently proven to be a clinically applicable strategy for the treatment of several mis-splice disorders. Despite this, wider application of SSOs is severely limited by the inherently poor bioavailability of SSO-based therapeutic compounds. Cell-penetrating peptides (CPPs) are a class of drug delivery systems (DDSs) that have recently gained considerable attention for improving the uptake of various oligonucleotide (ON)-based compounds, including SSOs. One strategy that has been successfully applied to develop effective CPP vectors is the introduction of various lipid modifications into the peptide. Here, we repurpose hydrocarbon-modified amino acids used in peptide stapling for the orthogonal introduction of hydrophobic modifications into the CPP structure during peptide synthesis. Our data show that α,α-disubstituted alkenyl-alanines can be successfully utilized to introduce hydrophobic modifications into CPPs to improve their ability to formulate SSOs into nanoparticles (NPs), and to mediate high delivery efficacy and tolerability both in vitro and in vivo. Conclusively, our results offer a new flexible approach for the sequence-specific introduction of hydrophobicity into the structure of CPPs and for improving their delivery properties.

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