Risk of venous thromboembolism in association with factor V leiden in cancer patients – The EDITH case-control study

Abstract Introduction: Factor V Leiden is the most common inherited risk factor for venous thromboembolism (VTE). A four- to sevenfold increased risk of VTE for the heterozygous state has been reported by numerous epidemiological studies but most of them did not include patients over 70 years. Surprisingly, we found in a previous study no association between Factor V Leiden and VTE in patients over 70 years. Methods Therefore we conducted a large hospital-based matched case-control study to test the hypothesis of an interaction between age and the factor V mutation, as well as G20210A prothrombin gene variation. Results: We analysed 392 patients experiencing VTE not related to a major acquired risk factor and their matched controls. Factor V Leiden was not associated with VTE in patients aged 80 years and over: odds ratio 0.8 (95%CI 0.2-3.4). There was a significant interaction between age and the mutation for VTE risk (p=0.03). Conversely, the association between the G20210A variant and VTE was consistent across age-groups: odds ratio 2.8 (95%CI 1.4–5.8). In conclusion, age may modify the relation between factor V Leiden and VTE. The prevalence of the factor V mutation decreased with increasing age among patients with VTE but not among controls.

Download Full-text

Factor V Leiden (R506Q) and risk of venous thromboembolism: a case-control study based on the Spanish population

Clinical Genetics ◽

10.1111/j.1399-0004.1997.tb02548.x ◽

2008 ◽

Vol 52 (4) ◽

pp. 206-210 ◽

Cited By ~ 18

Author(s):

José M. García-Gala ◽

Victoria Alvarez ◽

Carmen R. Pinto ◽

Inmaculada Soto ◽

Manuel F. Urgellés ◽

...

Keyword(s):

Venous Thromboembolism ◽

Case Control Study ◽

Factor V Leiden ◽

Case Control ◽

Spanish Population ◽

Factor V ◽

Control Study

Download Full-text

Frequency of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphism in patients with venous thromboembolism: Croatian case control study

Biochemia Medica ◽

10.11613/bm.2010.028 ◽

2010 ◽

pp. 229-235 ◽

Cited By ~ 13

Author(s):

Zrinka Alfirevic ◽

Ana-Maria Simundic ◽

Nora Nikolac ◽

Nikola Sobocan ◽

Igor Alfirevic ◽

...

Keyword(s):

Venous Thromboembolism ◽

Case Control Study ◽

Factor V Leiden ◽

Mthfr C677t ◽

Case Control ◽

Factor V ◽

Factor Ii ◽

Pai 1 ◽

Control Study

Download Full-text

Activated protein C-resistance due to factor V leiden mutation among patients with inflammatory bowel disease: A case-control study

Gastroenterology ◽

10.1016/s0016-5085(98)83755-4 ◽

1998 ◽

Vol 114 ◽

pp. A922

Author(s):

S. Ardizzone ◽

S. Bollani ◽

P. Molteni ◽

U. Russo ◽

E. Rossi ◽

...

Keyword(s):

Protein C ◽

Case Control Study ◽

Activated Protein C ◽

Factor V Leiden ◽

Case Control ◽

Factor V ◽

Activated Protein C Resistance ◽

Factor V Leiden Mutation ◽

Inflammatory Bowel ◽

Control Study

Download Full-text

Risk factors for incident venous thromboembolism in active cancer patients: A population based case–control study

Thrombosis Research ◽

10.1016/j.thromres.2016.01.002 ◽

2016 ◽

Vol 139 ◽

pp. 29-37 ◽

Cited By ~ 29

Author(s):

Aneel A. Ashrani ◽

Rachel E. Gullerud ◽

Tanya M. Petterson ◽

Randolph S. Marks ◽

Kent R. Bailey ◽

...

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Cancer Patients ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Control Study ◽

Active Cancer

Download Full-text

High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis

Thrombosis and Haemostasis ◽

10.1160/th06-11-0616 ◽

2007 ◽

Vol 97 (02) ◽

pp. 171-175 ◽

Cited By ~ 9

Author(s):

Mohamed Baba-Ahmed ◽

Grégoire Le Gal ◽

Francis Couturaud ◽

Karine Lacut ◽

Emmanuel Oger ◽

...

Keyword(s):

Venous Thromboembolism ◽

Close Association ◽

Factor V Leiden ◽

Plaster Cast ◽

Case Control ◽

Factor V ◽

Potential Significance ◽

Control Study ◽

Fvl Mutation

SummaryAmong candidate risk factors associated with postoperative venous thromboembolism (VTE), the role of factorV Leiden (FVL) mutation remains unclear. We performed a case-control study to assess the potential significance of FVL mutation in postoperative VTE cases despite prophylaxis. We used data from the ongoing case-control “EDITH” study. We extracted 133VTE cases and 144 controls who had undergone either surgery or had plaster cast in the previous three months. Prophylaxis adequacy with regard to the recommendations published by theAmerican College of Chest Physicians was retrospectively assessed. FVL mutation was present in 20VTE cases and four controls (OR 5.9, 95% CI 2–18). Prophylaxis was judged as adequate in 116 cases (88.5 %) and in 129 controls (87.2 %) (p = 0.66). The frequency of FVL mutation was not different in VTE cases occurring while on adequate prophylaxis and in VTE cases occurring after the end of adequate prophylaxis (p = 0.27). FVL mutation was closely associated with postoperative VTE in patients classified as having received an adequate prophylaxis (8.4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomaticVTE occurring after surgery despite prophylaxis.

Download Full-text