scholarly journals Single transcranial direct current stimulation in schizophrenia: Randomized, cross-over study of neurocognition, social cognition, ERPs, and side effects

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197023 ◽  
Author(s):  
Yuri Rassovsky ◽  
Walter Dunn ◽  
Jonathan K. Wynn ◽  
Allan D. Wu ◽  
Marco Iacoboni ◽  
...  
Keyword(s):  
Social Cognition ◽  
Side Effects ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

scholarly journals Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mauro Adenzato ◽  
Rosa Manenti ◽  
Elena Gobbi ◽  
Ivan Enrici ◽  
Danila Rusich ◽  
...  
Keyword(s):  
Social Cognition ◽  
Theory Of Mind ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cognitive Abilities ◽  
Healthy Aging ◽  
Cognitive Theory ◽  
Controlled Study ◽  
Double Blind ◽  
Direct Current Stimulation

AbstractAging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants.

scholarly journals Feasibility and Safety of Transcranial Direct Current Stimulation in an Outpatient Rehabilitation Setting After Stroke

2020 ◽  
Vol 10 (10) ◽  
pp. 719
Author(s):  
Brice T. Cleland ◽  
Melissa Galick ◽  
Amy Huckstep ◽  
Laura Lenhart ◽  
Sangeetha Madhavan
Keyword(s):  
Side Effects ◽  
Direct Current ◽  
Clinical Setting ◽  
Transcranial Direct Current Stimulation ◽  
Outpatient Rehabilitation ◽  
Clinical Settings ◽  
Clinical Use ◽  
Direct Current Stimulation ◽  
Acute Changes ◽  
Therapy Sessions

Transcranial direct current stimulation (tDCS) has strong potential for outpatient clinical use, but feasibility and safety of tDCS has only been evaluated in laboratory and inpatient clinical settings. The objective of this study was to assess feasibility and safety of tDCS for stroke in an outpatient clinical setting. Individuals with stroke in outpatient therapy received tDCS during physical therapy sessions. Feasibility was assessed with screening, enrollment, withdrawal, and adherence numbers, tDCS impressions, and perceived benefits and detriments of tDCS. Acute changes in fatigue and self-reported function and pre-post changes in fatigue were also assessed. Safety was assessed as adverse events and side effects. In total, 85 individuals were screened, and 10 were enrolled. Most exclusions were unrelated to clinical feasibility. In total, 3 participants withdrew, so 7 participants completed 2 sessions/week for 5–6 weeks with 100% adherence. In total, 71% reported positive impressions of tDCS. tDCS setup decreased to 5–7 min at end of study. There was one adverse event unrelated to tDCS. Mild to moderate side effects (tingling, itching, pinching, and fatigue) were experienced. In total, 86% of participants recounted benefits of tDCS. There were acute improvements in function and energy. Results support the feasibility and safety of tDCS in an outpatient clinical setting.

The effect of transcranial direct current stimulation on social cognition in schizophrenia: A preliminary study

2015 ◽  
Vol 165 (2-3) ◽  
pp. 171-174 ◽  
Author(s):  
Yuri Rassovsky ◽  
Walter Dunn ◽  
Jonathan Wynn ◽  
Allan D. Wu ◽  
Marco Iacoboni ◽  
...  
Keyword(s):  
Social Cognition ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Preliminary Study

scholarly journals Effects of transcranial direct current stimulation upon attention and visuoperceptual function in Lewy body dementia: a preliminary study

2015 ◽  
Vol 28 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Greg J. Elder ◽  
Michael J. Firbank ◽  
Hrishikesh Kumar ◽  
Payel Chatterjee ◽  
Titas Chakraborty ◽  
...  
Keyword(s):  
Reaction Time ◽  
Side Effects ◽  
Choice Reaction Time ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Lewy Body ◽  
Lewy Body Dementia ◽  
Direct Current Stimulation ◽  
Preliminary Study ◽  
Task Accuracy

ABSTRACTBackground:Individuals with Lewy body dementia (LBD) typically exhibit impairments in attentional and executive function. Current pharmacological treatments have limited efficacy, with associated side effects. Transcranial direct current stimulation (tDCS) may represent an alternative treatment, as cognitive improvements have been demonstrated in healthy individuals. However, no studies to date have assessed the feasibility of tDCS in an LBD population. The aim of this preliminary study, therefore, was to assess the tolerability of tDCS, as well as its effects upon attentional and visuoperceptual performance, in LBD patients.Methods:Thirteen participants completed attentional (simple reaction time, choice reaction time, and digit vigilance) and forced-choice visuoperceptual (angle and motion perception) tasks before and after one 20-min session of active tDCS (0.08 mA/cm2). The anodal electrode was applied to the left dorsolateral prefrontal cortex and the cathodal electrode was applied to the right deltoid. Attentional (task accuracy and reaction time to correct answers) and visuoperceptual (task accuracy and difficulty) outcome measures were compared using paired t-tests.Results:All participants tolerated stimulation and did not report any side effects during or immediately after stimulation. Post-stimulation improvements were observed in the choice reaction time (increased percentage of correct answers; p = 0.01) and digit vigilance (reduced mean reaction time to correct answers; p = 0.02) attention tasks. Visuoperceptual task performance did not improve (all p-values > 0.05).Conclusions:Attentional, but not visuoperceptual, improvements were observed following stimulation in LBD patients. Larger-scale, placebo-controlled trials are needed to confirm whether tDCS is a useful treatment option for attentional deficits in LBD.

scholarly journals Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial

2021 ◽  
Vol 11 (4) ◽  
pp. 317
Author(s):  
Yuji Yamada ◽  
Takuma Inagawa ◽  
Yuma Yokoi ◽  
Aya Shirama ◽  
Kazuki Sueyoshi ◽  
...  
Keyword(s):  
Social Cognition ◽  
Study Protocol ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Primary Outcome Measure ◽  
Psychotic Symptoms ◽  
Efficacy And Safety ◽  
Open Label ◽  
Direct Current Stimulation

Backgrounds: Social cognition is defined as the mental operations underlying social behavior. Patients with schizophrenia elicit impairments of social cognition, which is linked to poor real-world functional outcomes. In a previous study, transcranial direct current stimulation (tDCS) improved emotional recognition, a domain of social cognition, in patients with schizophrenia. However, since social cognition was only minimally improved by tDCS when administered on frontal brain areas, investigations on the effect of tDCS on other cortical sites more directly related to social cognition are needed. Therefore, we present a study protocol to determine whether multi-session tDCS on superior temporal sulcus (STS) would improve social cognition deficits of schizophrenia. Methods: This is an open-label, single-arm trial, whose objective is to investigate the efficacy and safety of multi-session tDCS over the left STS to improve social cognition in patients with schizophrenia. The primary outcome measure will be the Social Cognition Screening Questionnaire. Neurocognition, functional capacity, and psychotic symptoms will also be evaluated by the Brief Assessment of Cognition in Schizophrenia, UCSD Performance-Based Skills Assessment-Brief, and Positive and Negative Syndrome Scale, respectively. Data will be collected at baseline, and 4 weeks after the end of intervention. If social cognition is improved in patients with schizophrenia by tDCS based on this protocol, we may plan randomized controlled trial.

scholarly journals Repeated Sessions of Transcranial Direct Current Stimulation on Adolescents With Autism Spectrum Disorder: Study Protocol for a Randomized, Double-Blind, and Sham-Controlled Clinical Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Karin Prillinger ◽  
Stefan T. Radev ◽  
Gabriel Amador de Lara ◽  
Manfred Klöbl ◽  
Rupert Lanzenberger ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Autism Spectrum Disorder ◽  
Social Cognition ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Direct Current Stimulation

Background: Social–emotional difficulties are a core symptom of autism spectrum disorder (ASD). Accordingly, individuals with ASD have problems with social cognition such as recognizing emotions from other peoples' faces. Various results from functional magnetic resonance imaging and electroencephalography studies as well as eye-tracking data reveal a neurophysiological basis of these deficits by linking them to abnormal brain activity. Thus, an intervention targeting the neural origin of ASD impairments seems warranted. A safe method able to influence neural activity is transcranial direct current stimulation (tDCS). This non-invasive brain stimulation method has already demonstrated promising results in several neuropsychiatric disorders in adults and children. The aim of this project is to investigate the effects of tDCS on ASD symptoms and their neural correlates in children and adolescents with ASD.Method: This study is designed as a double-blind, randomized, and sham-controlled trial with a target sample size of 20 male participants (aged 12–17 years) diagnosed with ASD. Before randomization, the participants will be stratified into comorbid depression, comorbid ADHS/conduct disorder, or no-comorbidity groups. The intervention phase comprises 10 sessions of anodal or sham tDCS applied over the left prefrontal cortex within 2 consecutive weeks. To engage the targeted brain regions, participants will perform a social cognition training during the stimulation. TDCS-induced effects on ASD symptoms and involved neural circuits will be investigated through psychological, neurophysiological, imaging, and behavioral data at pre- and post-measurements. Tolerability will be evaluated using a standardized questionnaire. Follow-up assessments 1 and 6 months after the intervention will examine long-lasting effects.Discussion: The results of this study will provide insights into the changeability of social impairments in ASD by investigating social and emotional abilities on different modalities following repeated sessions of anodal tDCS with an intra-simulation training. Furthermore, this trial will elucidate the tolerability and the potential of tDCS as a new treatment approach for ASD in adolescents.Clinical Trial Registration: The study is ongoing and has been registered in the German Registry of Clinical Trials (DRKS00017505) on 02/07/2019.

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