Introduction. A high platelet count, or thrombocytosis, is either a reactive
process or a result of a myeloproliferative disorder. Ankylosing spondylitis
is a chronic inflammatory rheumatic disease affecting the spine and sometimes
peripheral joints in which reactive mild to moderate thrombocytosis is a
common finding. There have been no previously reported cases of essential
thrombocythemia associated with ankylosing spondylitis. Case Outline. We
report a case of a 32-year-old man with human leukocyte antigen B27-positive
ankylosing spondylitis and Janus kinase 2-positive essential thrombocythemia
who was treated first with a combination of anagrelide and disease-modifying
antirheumatic drugs and, after liver toxicity, with a combination of
anagrelide and etanercept (TNF-? antagonist). Both diseases were gradually
brought under control. Conclusion. Our case of ankylosing spondylitis and
essential thrombocythemia suggests that concomitant etanercept and anagrelide
therapy is safe, as well as effective.
Human leukocyte antigen and demographic characteristics in Chinese patients with active peripheral type psoriatic arthritis who had inadequate response to conventional disease-modifying antirheumatic drugs in a single dermatologic clinic
