Mortality risk in adults according to categories of impaired glucose metabolism after 18 years of follow-up in the North of Spain: The Asturias Study

Abstract Objective: The aim of this study was to assess body shape trajectories in childhood and midlife in relation to subsequent risk of breast cancer (BC) in a Mediterranean cohort. Design: The ‘Seguimiento Universidad de Navarra’ (SUN) Project is a dynamic prospective cohort study of university graduates initiated in 1999. With a group-based modelling approach, we assessed body shape trajectories from age 5 to 40 years. Multivariable Cox regression models were used to estimate the hazard ratio (HR) for BC after the age of 40 years according to the body shape trajectory. Setting: City of Pamplona, in the North of Spain. Participants: 6498 women with a mean age of 40 years (sd 9). Results: We identified four distinct body shape trajectories (‘childhood lean-midlife increase’ (19·9 %), ‘childhood medium-midlife stable’ (53 %), ‘childhood heavy-midlife stable’ (21 %) and ‘childhood heavy-midlife increase’ (6·1 %)). Among 54 978 women-years of follow-up, we confirmed eighty-two incident cases of BC. Women in the ‘childhood lean-midlife increase’ group showed a higher risk of BC (HR = 1·84, 95 % CI 1·11, 3·04) compared with women in the ‘childhood medium-midlife stable’ category. This association was stronger for postmenopausal BC (HR = 2·42, 95 % CI 1·07, 5·48). Conclusions: Our results suggest a role for lifetime adiposity in breast carcinogenesis.

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Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study

Occupational and Environmental Medicine ◽

10.1136/oemed-2019-106170 ◽

2020 ◽

Vol 77 (5) ◽

pp. 324-332 ◽

Cited By ~ 1

Author(s):

Tuulia Varanka-Ruuska ◽

Mimmi Tolvanen ◽

Eeva Vaaramo ◽

Sirkka Keinänen-Kiukaanniemi ◽

Sylvain Sebert ◽

...

Keyword(s):

Glucose Metabolism ◽

Birth Cohort ◽

Working Life ◽

Glycated Haemoglobin ◽

Oral Glucose ◽

Impaired Glucose Metabolism ◽

Total Employment ◽

Normal Glucose ◽

Rate Ratios

ObjectiveTo evaluate how clinically measured glucose metabolism categories predict registered participation in working life.MethodsIn the 46-year follow-up of Northern Finland Birth Cohort 1966 (n=5328, 2342 men and 2986 women), we used oral glucose tolerance tests, surveys and glycated haemoglobin to determine glucose metabolism categorised as normal, pre-diabetes, screen-detected and previous type 2 diabetes (T2D). Consequent participation in working life during the 2-year follow-up period was measured as registered disability, unemployment and employment days, for which incidence rate ratios (IRRs) with 95% CIs were calculated using Poisson regression, adjusted for baseline employment and socioeconomic, health-related and behavioural factors.ResultsIn comparison to normal glucose, all categories of impaired glucose metabolism were associated with poorer participation in working life in the unadjusted models. After adjustments, the risks (IRR (95% CI)) of disability days remained heightened by both screen-detected and previous T2D among men (1.3 (1.3 to 1.4) and 1.5 (1.4 to 1.5), respectively), whereas among women the risks were lowered (0.9 (0.8 to 0.9) and 0.9 (0.9 to 1.0), respectively). The risks of unemployment were consistently higher in all categories of impaired glucose metabolism, and were the highest among women with previous T2D (1.6 (1.5 to 1.6)). Correspondingly, the rates of total employment days were lower in relation to screen-detected T2D among men and women (5% and 6%, respectively), and previous T2D (6% and 3%).ConclusionsOverall, impaired glucose metabolism associated with deteriorated working life participation already in middle age. The high prevalence of impaired glucose metabolism emphasises the need for actions to support sustainable working careers.

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Impact of Impaired Glucose Metabolism on Periodontitis Progression over Three Years

Dentistry Journal ◽

10.3390/dj10010010 ◽

2022 ◽

Vol 10 (1) ◽

pp. 10

Author(s):

Oelisoa M. Andriankaja ◽

Kaumudi Joshipura ◽

Francisco Muñoz ◽

Bruce A. Dye ◽

Frank B. Hu ◽

...

Keyword(s):

Insulin Resistance ◽

Glucose Metabolism ◽

Fasting Glucose ◽

Impaired Glucose Metabolism ◽

Pocket Depth ◽

Clinical Attachment Loss ◽

The Relationship ◽

Overweight Adults ◽

Glucose Abnormalities

We evaluated the relationship between glucose abnormalities and periodontitis in overweight/obese individuals. Eight hundred and seventy (870) diabetes-free participants aged 40–65 years completed the three-year follow-up in the San Juan Overweight Adults Longitudinal Study. The ADA thresholds for fasting and 2-h post-load glucose and HbA1c were used to define prediabetes. The NHANES methods were used to assess periodontitis. Multivariable linear regression was used to evaluate the relationship between baseline glucose metabolism measures and periodontitis at follow-up, adjusting for potential confounders. There was no association between impaired glucose measures and mean pocket depth (PD), mean clinical attachment loss (CAL), or mean percent of sites ≥5 mm PD. Impaired glucose tolerance (IGT) was associated with a lower mean percent of sites ≥5 mm CAL (β = −1.6, p = 0.037). Prediabetes and impaired fasting glucose (IFG) were associated with improvement in mean percent of sites ≥5 mm PD (β = −1.4, p = 0.022; β = −1.6, p = 0.032; respectively). IFG and IGT were associated with improvement in mean percent of sites with ≥5 mm CAL (β = −1.6, p = 0.038; β = −1.9, p = 0.020; respectively). In conclusion, there were no consistent associations between baseline prediabetes or insulin resistance and periodontitis progression over a three-year period.

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M.527 Relation between impaired glucose metabolism and coronary artery disease

Atherosclerosis ◽

10.1016/s0021-9150(04)90525-4 ◽

2004 ◽

Vol 5 (1) ◽

pp. 122

Author(s):

A GOTSIS

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Glucose Metabolism ◽

Impaired Glucose Metabolism ◽

Artery Disease

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1588: The Bicalutamide Early Prostate Cancer Program: Findings of the North American Trial at 7.7 Years' Median Follow-Up

The Journal of Urology ◽

10.1016/s0022-5347(18)33780-7 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 511-512

Author(s):

David G. McLeod ◽

Ira Klimberg ◽

Donald Gleason ◽

Gerald Chodak ◽

Thomas Morris ◽

...

Keyword(s):

Prostate Cancer ◽

North American ◽

Early Prostate Cancer ◽

The North ◽

Cancer Program

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Emergency Department Admission and Mortality Rate for Suicidal Behavior

Crisis ◽

10.1027/0227-5910/a000282 ◽

2014 ◽

Vol 35 (6) ◽

pp. 406-414 ◽

Cited By ~ 10

Author(s):

Raimondo Maria Pavarin ◽

Angelo Fioritti ◽

Francesca Fontana ◽

Silvia Marani ◽

Alessandra Paparelli ◽

...

Keyword(s):

Emergency Department ◽

Metropolitan Area ◽

Suicidal Behavior ◽

Mortality Risk ◽

Illicit Drugs ◽

Attempted Suicide ◽

Cox Model ◽

Emergency Department Admission ◽

Completed Suicide

Background: The international literature reports that for every completed suicide there are between 8 and 22 visits to an Emergency Department (ED) for attempted suicide/suicidal behavior. Aims: To describe the characteristics of admission to emergency departments (EDs) for suicide-related presenting complaints in the metropolitan area of Bologna; to estimate the risk for all-cause mortality and for suicide; to identify the profiles of subjects most at risk. Method: Follow-up of patients admitted to the EDs of the metropolitan area of Bologna between January 2004 and December 2010 for attempted suicide. A Cox model was used to evaluate the association between sociodemographic variables and the general mortality risk. Results: We identified 505 cases of attempted suicide, which were more frequent for female subjects, over the weekend, and at night (8:00 p.m./8:00 a.m.). The most used suicide methods were psychotropic drugs, sharp or blunt objects, and jumping from high places. In this cohort, 3.6% of subjects completed suicide (4.5% of males vs. 2.9% of females), 2.3% within 1 year of the start of follow-up. The most common causes of death were drug use and hanging. In the multivariate analysis, those who used illicit drugs 24 hr prior to admission to the ED (hazard ratio [HR] = 3.46, 95% CI = 1.23–9.73) and patients who refused the treatment (HR = 6.74, 95% CI = 1.86–24.40) showed an increased mortality risk for suicide. Conclusion: Deliberate self-harm patients presenting to the ED who refuse treatment represent a specific target group for setting up dedicated prevention schemes.

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