scholarly journals Predictive value of cystatin C and neutrophil gelatinase-associated lipocalin in contrast-induced nephropathy: A meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0230934
Author(s):  
Yi He ◽  
Yunzhen Deng ◽  
Kaiting Zhuang ◽  
Siyao Li ◽  
Jing Xi ◽  
...  
Keyword(s):  
Cystatin C ◽  
Predictive Value ◽  
Meta Analysis ◽  
Contrast Induced Nephropathy ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis

Angiology ◽  
2021 ◽  
pp. 000331972110044
Author(s):  
Hongling Xu ◽  
Hongye Wang ◽  
Chuang Zhang ◽  
Jun Xiao ◽  
Ning Hua ◽  
...  
Keyword(s):  
Meta Analysis ◽  
China National Knowledge Infrastructure ◽  
Contrast Induced Nephropathy ◽  
Serum Cystatin ◽  
Assessment Development ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Knowledge Infrastructure ◽  
Evidence Evaluation ◽  
Biological Medicine ◽  
Neutrophil Gelatinase

This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 µg/d alprostadil or 20 µg/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 µg/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.

scholarly journals Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

2021 ◽  
Author(s):  
Julie Mouron-Hryciuk ◽  
François Cachat ◽  
Paloma Parvex ◽  
Thomas Perneger ◽  
Hassib Chehade
Keyword(s):  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Serum Creatinine ◽  
Brain Natriuretic Peptide ◽  
Glomerular Filtration ◽  
Natriuretic Peptide ◽  
Cystatin C ◽  
Filtration Rate ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

AbstractGlomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known:• Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR.• The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New:• The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.

scholarly journals Changes in Urinary and Serum Levels of Novel Biomarkers after Administration of Gadolinium-based Contrast Agents

2016 ◽  
Vol 11 ◽  
pp. BMI.S39199 ◽  
Author(s):  
Habib Mawad ◽  
Louis-Philippe Laurin ◽  
Jean-François Naud ◽  
François A. Leblond ◽  
Nathalie Henley ◽  
...  
Keyword(s):  
Renal Function ◽  
Contrast Agents ◽  
Cystatin C ◽  
Normal Renal Function ◽  
Serum Levels ◽  
Serum Cystatin C ◽  
Baseline Serum ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Novel Biomarkers ◽  
Neutrophil Gelatinase

Objective The aim of our study is to describe the changes in urinary and serum levels of novel biomarkers after gadolinium contrast administration in patients with normal renal function. Methods We measured four biomarkers in 28 volunteers: interleukin-18 (IL-18), N-acetyl-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and cystatin C. Urinary and serum samples were collected at 0, 3, and 24 hours following gadolinium administration. Results Baseline serum creatinine was 57.8 ± 34.5 μmol/L and remained stable. Urinary IL-18 levels increased significantly at three hours (10.7 vs. 7.3 ng/mg creatinine; P < 0.05). Similarly, urinary NAG levels increased significantly at three hours (3.9 vs. 2.2 IU/mg creatinine; P < 0.001). For both these markers, the difference was no longer significant at 24 hours. No statistically significant differences were observed for urinary and serum neutrophil gelatinase-associated lipocalin levels and for serum cystatin C levels. Conclusions Urinary IL-18 and NAG levels increased transiently after administration of gadolinium-based contrast agents in patients with normal renal function.

Neutrophil gelatinase-associated lipocalin as a potential biomarker for pulmonary thromboembolism

2019 ◽  
Vol 45 (1) ◽  
pp. 51-56
Author(s):  
Songul Ozyurt ◽  
Mevlut Karatas ◽  
Medeni Arpa ◽  
Bilge Yilmaz Kara ◽  
Hakan Duman ◽  
...  
Keyword(s):  
Predictive Value ◽  
Pulmonary Thromboembolism ◽  
High Sensitivity ◽  
Control Group ◽  
Arterial Blood Gas ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Arterial Blood ◽  
Potential Biomarker ◽  
Healthy Control ◽  
Neutrophil Gelatinase

Abstract Objective Pulmonary thromboembolism (PTE) is a clinical condition that can be lethal unless promptly diagnosed and treated. The objective was to evaluate the significance of serum neutrophil gelatinase-associated lipocalin (NGAL) in the diagnosis of PTE. Materials and methods In this study, 60 patients hospitalized for acute PTE between May 2015 and December 2016 were enrolled. PTE was diagnosed using spiral computed tomography angiography of the thorax. Cardiac enzyme levels, arterial blood gas, and echocardiography measurements were performed. Whole blood samples were drawn to measure serum NGAL before treatment. Results The PTE group comprised 34 women and 26 men, and the healthy control group included 22 women and 18 men. The mean ages of the patient and control groups were 70.3 ± 14.4 years and 69.0 ± 10.2 years, respectively. Serum NGAL was significantly higher in the patients than in the controls (88.6 ± 33.6 vs. 31.7 ± 10.0 ng/mL, p < 0.001, respectively). The optimal NGAL cut-off value was >50 ng/mL, the sensitivity was 100%, specificity was 98.3%, the negative predictive value was 100%, and the positive predictive value was 68%. Conclusion Serum NGAL is a new biomarker with high sensitivity and specificity to detect, diagnose, and exclude PTE.

scholarly journals Μελέτη μοριακών δεικτών της οξείας νεφρικής βλάβης στο πλάσμα και στα ούρα κατά την εξωσωματική λιθοθρυψία

2014 ◽  
Author(s):  
Ιωάννης Καρδάκος
Keyword(s):  
Cystatin C ◽  
Interleukin 18 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Η λιθίαση αποτελεί την πιο συχνή πάθηση του ουροποιητικού συστήματος και ένα από τα συνηθέστερα επείγοντα ουρολογικά συμβάματα, ενώ διατηρεί μία ευρεία αιτιολογική βάση παθογένειας, επηρεαζόμενη από γενετικά καθορισμένους παράγοντας, όπως και από πλήθος δημογραφικών και περιβαλλοντικών μεταβλητών. Η αντιμετώπιση της λιθίασης τα τελευταία χρόνια πλαισιώνεται από επαναστατικές τεχνολογικές αλλαγές, καθώς πλέον λιγότερο από 5% των περιπτώσεων λιθίασης αντιμετωπίζεται με την παραδοσιακή ανοιχτή χειρουργική μέθοδο. Έτσι, η μέθοδος της εξωσωματικής λιθοτριψίας με την παραγωγή κυμάτων κρούσης εφαρμόζεται ευρέως, παρουσιάζοντας εξαιρετική αποτελεσματικότητα, αν και σε ορισμένες περιπτώσεις ενδέχεται να προκαλέσει νεφρική βλάβη. Τα τελευταία χρόνια, η εξέταση μοριακών δεικτών της οξείας νεφρικής βλάβης μετά την εφαρμογή της εξωσωματικής λιθοθρυψίας είναι εξαιρετικά δημοφιλής, με σκοπό την έγκαιρη διάγνωση και αποτελεσματική αντιμετώπισή της. Σκοπός της παρούσας διδακτορικής διατριβής είναι η εξέταση των μοριακών δεικτών Plasma neutrophil Gelatinase-Associated Lipocalin (NGAL) στο πλάσμα και στα ούρα, cystatin C στο πλάσμα και Interleukin -18 (IL-18) στα ούρα, καθώς οι δείκτες αυτοί έχουν ανεβρεθεί αυξημένοι σε καταστάσεις οξείας νεφρικής βλάβης, έχοντας τη δυνατότητα να αναδείξουν τον βαθμό της νεφρικής βλάβης μετά την εξωσωματική λιθοθρυψία. Σύμφωνα με τα αποτελέσματα αν και οι εξεταζόμενοι μοριακοί δείκτες φαίνεται πως αποτελούν σημαντικούς δείκτες για την αποτελεσματικότητα της εξωσωματικής λιθοθρυψίας και την ιστική κατάσταση του νεφρού μετά την εφαρμογή αυτής της μη επεμβατικής μεθόδου, παρόλα αυτά οι μη στατιστικές διαφορές που επισημάνθηκαν ανάμεσα στα διάφορα ζεύγη των μετρήσεων πριν και μετά την εφαρμογή της μεθόδου καταδεικνύουν πως δεν είναι επαρκείς για την ανάδειξη νεφρικής βλάβης, και για το λόγο αυτό χρήζουν περαιτέρω διερεύνησης. Λέξεις κλειδιά: NGAL, Cystatin C, Interleukin 18, εξωσωματική λιθοτριψία

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