scholarly journals Stable and efficient immobilization of bi-enzymatic NADPH cofactor recycling system under consecutive microwave irradiation

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242564
Author(s):  
Rong Chen ◽  
Qiuhui Wei ◽  
Xin Wei ◽  
Yuheng Liu ◽  
Xiaomin Zhang ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Redox Reactions ◽  
Glucose Dehydrogenase ◽  
Relative Activity ◽  
Efficient Catalyst ◽  
Recycling System ◽  
Cofactor Recycling ◽  
Industrial Preparation ◽  
Enzymatic Cascades ◽  
Mesocellular Siliceous Foams

One of the challenges in biocatalysis is the development of stable and efficient bi-enzymatic cascades for bio-redox reactions coupled to the recycling of soluble cofactors. Aldo-keto reductase (LEK) and glucose dehydrogenase (GDH) can be utilized as the NADPH recycling system for economic and efficient biocatalysis of (R)-4-chloro-3-hydroxybutanoate ((R)-CHBE), an important chiral pharmaceutical intermediate. The LEK and GDH was efficiently co-immobilized in mesocellular siliceous foams (MCFs) under microwave irradiation (CoLG-MIA). while they were also co-immobilized by entrapment in calcium alginate without MIA as control (CoLG-CA). The relative activity of CoLG-MIA was increased to 140% compared with that of free LEK. The CoLG-MIA exhibited a wider range of pH and temperature stabilities compared with other preparations. The thermal, storage and batch operational stabilities of microwave-assisted immobilized LEK-GDH were also improved. The NADPH recycling system exhibited the potential as the stable and efficient catalyst for the industrial preparation of (R)-CHBE.

scholarly journals Microwave-assisted urea catalyzed Knoevenagel condensation of aldehydes with active methylene compounds

2020 ◽  
Vol 55 (2) ◽  
pp. 159-164
Author(s):  
WT Purba ◽  
PS Roy ◽  
S Jannat ◽  
SA Begum ◽  
MM Rahman
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Knoevenagel Condensation ◽  
Efficient Catalyst ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Wide Range ◽  
Active Methylene Compounds ◽  
Reaction Proceeds ◽  
Active Methylene

Rapid and efficient method for the synthesis of substituted olefins such as 2-(4-chlorophenylmethylene) malononitrile, 2-(4-hydroxyphenylmethylene) malononitrile and 2-cyano-3-(4-hydroxyphenyl) acrylamide etc under the influence of microwave irradiation are described. Urea has been utilized as an efficient catalyst for the Knoevenagel condensation of aldehydes with acidic active methylene compounds such as malononitrile, ethylcyanoacetate and cyanoacetamide to afford substituted olefins under the influence of microwave irradiation. The reaction proceeds smoothly under mild and solvent free conditions and the products are obtained in good yield. The method is applicable for a wide range of aldehydes including aromatic and heterocyclic substrates. Bangladesh J. Sci. Ind. Res.55(2), 159-164, 2020

One step synthesis of silane-capped copper clusters as a sensitive optical probe and efficient catalyst for reversible color switching

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38897-38905 ◽  
Author(s):  
Shaochen Zhou ◽  
Yingxuan Li ◽  
Fu Wang ◽  
Chuanyi Wang
Keyword(s):  
Methylene Blue ◽  
Redox Reactions ◽  
Optical Probe ◽  
Switching System ◽  
Efficient Catalyst ◽  
Copper Clusters ◽  
Highly Efficient ◽  
One Step ◽  
Color Switching

Luminescent silane-functionalized copper clusters are developed as a highly efficient catalyst to build up a recyclable and photoreversible color switching system based on the redox reactions of methylene blue.

scholarly journals Regioselective Copper-Catalysed Amination of Halobenzoic Acids using Aromatic Amines

2007 ◽  
Vol 2007 (10) ◽  
pp. 587-589 ◽  
Author(s):  
Mohan Babu Maradolla ◽  
Amaravathi Mandha ◽  
Chandra Mouli Garimella
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Amines ◽  
Reaction Times ◽  
Efficient Catalyst ◽  
High Yields

Copper dipyridine dichloride (CuPy2Cl2) has been found to be an efficient catalyst for the synthesis of N-arylanthranilic acids from ortho halobenzoic acids and aromatic amines under microwave irradiation. Some of the advantages of this method are high chemoselectivity, ease of operation, less reaction times and high yields. (61–98%).

Sulfamic acid: a novel and efficient catalyst for the synthesis of aryl-14H-dibenzo[a.j]xanthenes under conventional heating and microwave irradiation

2005 ◽  
Vol 46 (50) ◽  
pp. 8691-8693 ◽  
Author(s):  
B. Rajitha ◽  
B. Sunil Kumar ◽  
Y. Thirupathi Reddy ◽  
P. Narsimha Reddy ◽  
N. Sreenivasulu
Keyword(s):  
Microwave Irradiation ◽  
Sulfamic Acid ◽  
Conventional Heating ◽  
Efficient Catalyst

scholarly journals Ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br): A green and neutral reaction media for the efficient, catalyst-free synthesis of quinoxaline derivatives

2010 ◽  
Vol 75 (10) ◽  
pp. 1315-1324 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Abolfath Parhami ◽  
Ahmad Moosavi-Zare ◽  
Fatemeh Khedri ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Microwave Irradiation ◽  
Reaction Times ◽  
Efficient Catalyst ◽  
Neutral Reaction ◽  
Catalyst Free ◽  
Quinoxaline Derivatives ◽  
Reaction Media

Quinoxaline derivatives were produced in excellent yields and short reaction times via the condensation of 1,2-diamines with 1,2-diketones in the neutral ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) under catalyst-free and microwave irradiation conditions.

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