scholarly journals Kinetic and static perimetry after 16 years and additional OCT-A analysis in eyes with long-lasting optic disc drusen

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247399
Author(s):  
Edyta Koman-Wierdak ◽  
Katarzyna Nowomiejska ◽  
Agnieszka Brzozowska ◽  
Dominika Nowakowska ◽  
Mario Damiano Toro ◽  
...  
Keyword(s):  
Optic Disc ◽  
Superficial Layer ◽  
Retinal Nerve Fibre Layer ◽  
Macular Thickness ◽  
Vessel Density ◽  
Control Group ◽  
Automated Perimetry ◽  
Kinetic Perimetry ◽  
Rnfl Thickness ◽  
Optic Disc Drusen

The aim of the study is to evaluate the progression of visual field (VF) defects over 16 years of observation and to assess abnormalities in vessels and retinal nerve fibre layer (RNFL) thickness in patients with optic disc drusen (ODD). Both static automated perimetry (SAP) and semi-automated kinetic perimetry (SKP) were performed in 16 eyes of 8 patients (mean age 54 years) with ODD among 26 eyes of 13 patients examined 16 years before. The area of I2e, I4e, III4e, and V4e isopters was measured in deg2. The MD and PSD parameters were estimated using SAP. Optical coherence tomography angiography (OCT-A) was additionally performed in 16 ODD eyes and 16 eyes of 8 healthy subjects to estimate the RNFL thickness and vessel density of the optic nerve disc and the macula. The differences in all isopter areas of SKP and SAP parameters after 16 years were not significant. The analysis of OCT-A showed a significant reduction of the vessel density and RNFL of the peripapillary area in each segment in patients with ODD, compared with the control group. The highest reduction of RNFL was observed in the superior segment of the optic disc area (92.56μm vs 126.63μm) also the macular thickness was decreased in ODD patients, compared with the control group. In the macula, there was a significant vascular defect in the whole superficial layer and in the parafoveal deep layer. A strong significant correlation of the parafoveal deep plexus with MD and PSD parameters was detected. In conclusion, VF loss due to ODD after 16 years of the follow-up was not significant both in SKP and SAP. ODD caused a reduced vessel density and RNFL, as well as macular thickness in OCT-A. SAP parameters were influenced by parafoveal deep plexus.

scholarly journals Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder

2021 ◽  
Vol 10 (18) ◽  
pp. 4131
Author(s):  
Edyta Koman-Wierdak ◽  
Joanna Róg ◽  
Agnieszka Brzozowska ◽  
Mario Damiano Toro ◽  
Vincenza Bonfiglio ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Optic Disc ◽  
Microvascular Dysfunction ◽  
Macular Thickness ◽  
Vessel Density ◽  
Control Group ◽  
Vascular Density ◽  
Rnfl Thickness ◽  
Deep Layers ◽  
Peripapillary Area

Purpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers. Results: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and the control group. The macular thickness in the whole vascular complex and in the fovea was significantly lower in SZ and BD group than in the control group. The radiant peripapillary vascular density and RNFL thickness were similar across groups. Conclusions: The retinal microvascular dysfunction occurs in the macula in patients with SZ and BD, but not around optic disc. OCTA can become an essential additional diagnostic tool in detection of psychiatric disorders.

scholarly journals Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders

2019 ◽  
Vol 104 (2) ◽  
pp. 282-290 ◽  
Author(s):  
Jacqueline Chua ◽  
Florian Schwarzhans ◽  
Duc Quang Nguyen ◽  
Yih Chung Tham ◽  
Josh Tjunrong Sia ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Eye Diseases ◽  
Vessel Density ◽  
Rnfl Thickness ◽  
Nerve Fibre Layer ◽  
Retinal Vessel Density ◽  
Sd Oct

Background/AimsTo compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders.MethodsThe Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc centres (fovea distance) and their respective angle (fovea angle). Retinal vessels were segmented in the projection images and used to calculate the circumpapillary retinal vessel density profile. Compensated RNFL thickness was generated based on optic disc (ratio, orientation and area), fovea (distance and angle), retinal vessel density, refractive error and age. Linear regression models were used to investigate the effects of clinical factors on RNFL thickness.ResultsRetinal vessel density reduced significantly with increasing age (1487±214 µm in 40–49, 1458±208 µm in 50–59, 1429±223 µm in 60–69 and 1415±233 µm in ≥70). Compensation reduced the variability of RNFL thickness, where the effect was greatest for Chinese (10.9%; p<0.001), followed by Malays (6.6%; p=0.075) and then Indians (4.3%; p=0.192). Compensation reduced the age-related RNFL decline by 55% in all participants (β=−3.32 µm vs β=−1.50 µm/10 years; p<0.001). Nearly 62% of the individuals who were initially classified as having abnormally thin RNFL (outside the 99% normal limits) were later reclassified as having normal RNFL.ConclusionsRNFL thickness compensated for anatomical parameters reduced the variability of measurements and may improve glaucoma detection, which needs to be confirmed in future studies.

scholarly journals Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Weizhe Meng ◽  
Ronghua Li ◽  
Xiufen Xie
Keyword(s):  
Macular Edema ◽  
Intravitreal Injection ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Retinal Nerve Fibre Layer ◽  
Macular Thickness ◽  
Control Group ◽  
Panretinal Photocoagulation ◽  
Observation Group ◽  
Retinal Photocoagulation

Objective: To explore the clinical efficacy of intravitreal injection of conbercept in combination with retinal laser photocoagulation in the treatment of diabetic macular edema. Methods: Ninety patients with diabetic macular edema were selected and grouped into an observation group and a control group using random number table, 45 patients (45 eyes) each group. The control group was given retinal laser photocoagulation, while the observation group was given intravitreal injection of Conbercept on the basis of panretinal photocoagulation. The Best Corrected Visual Acuity (BCVA), thickness of retinal nerve fibre layer (RNFL) and macular thickness were measured through relevant examinations before and after treatment. The intraocular pressures of patients in the two groups were evaluated, and moreover the complications were recorded. Results: The RNFL thickness and macular thickness of the two groups had no statistically significant differences before treatment (P>0.05) and decreased significantly after treatment; the decrease amplitude of the observation group was significantly larger than that of the control group (P<0.05). The BCVA of both groups significantly increased in the 1st, 2nd and 4th week after treatment (P<0.05); the increase amplitude of BCVA of the observation group was more significant than that of the control group at different time points after treatment (P<0.05). The intraocular pressure of the observation group was not significantly different with that of the control group in the 1st, 2nd and 4th week after treatment (P>0.05). There were no severe eye complications and systemic adverse reactions in both groups in the process of follow up. Conclusion: Intravitreal injection of conbercept in combination with retinal laser photocoagulation performs better in improving the BCVA and central macular thickness of patients with diabetic macular edema compared to retinal laser photocoagulation and has high safety. doi: https://doi.org/10.12669/pjms.35.6.512 How to cite this:Meng W, Li R, Xie X. Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema. Pak J Med Sci. 2019;35(6):1493-1498. doi: https://doi.org10.12669/pjms.35.6.512 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Accuracy of the ISNT rule and its variants for differentiating glaucomatous from normal eyes in a population-based study

2020 ◽  
Vol 104 (10) ◽  
pp. 1412-1417 ◽  
Author(s):  
Edouard Maupin ◽  
Florian Baudin ◽  
Louis Arnould ◽  
Allasane Seydou ◽  
Christine Binquet ◽  
...  
Keyword(s):  
Optic Disc ◽  
Normal Subjects ◽  
Population Based ◽  
Retinal Nerve Fibre Layer ◽  
Population Based Study ◽  
Neuroretinal Rim ◽  
Rnfl Thickness ◽  
Thickness Measurements ◽  
Isnt Rule ◽  
Sd Oct

AimsTo evaluate the accuracy of the ISNT rule (I=inferior, S=superior, N=nasal, T=temporal) and its variants with neuroretinal rim width and retinal nerve fibre layer (RNFL) thickness measurements differentiating normal from glaucomatous eyes.MethodsThe diagnosis accuracy of the ISNT rule and its variants was evaluated in a population-based study. Neuroretinal rim widths were measured on monoscopic optic disc photographs with an image-processing program. RNFL thickness measurements were obtained with spectral-domain optical coherence tomography (SD-OCT).ResultsIn this study including 940 normal subjects and 93 patients with glaucoma, the sensitivity of the ISNT rule with optic disc photographs was 94.1% (95% CI 90.2 to 98.1), whereas its specificity was 49.2% (46.9 to 51.6). When using the IST rule, the sensitivity decreased to 69.9% (62.1 to 77.6) with a higher specificity, 87.0% (85.3 to 88.6). All the diagnosis indicators were somewhat lower for the different rules using RNFL thickness: the sensitivity of the ISNT rule was 79.4% (72.6 to 86.2) and its specificity was 34.1% (31.9 to 36.4). With the IST rule, the sensitivity decreased to 50.0% (41.6 to 58.4) while the specificity increased to 64.9% (62.7 to 67.2).ConclusionsThe ISNT and IST rules applied to neuroretinal rim width measurement by optic disc photographs are useful and simple tools for differentiating normal from glaucomatous eyes. The translation of these rules to RNFL thickness by SD-OCT is of limited value.

Determination of peripapillary vessel density in optic disc drusen using EDI-OCT and OCT angiography

2020 ◽  
Vol 197 ◽  
pp. 108123
Author(s):  
Anne-Sofie Wessel Lindberg ◽  
Vedrana Andersen Dahl ◽  
Isabelle Karlesand ◽  
Lea Lybek Rueløkke ◽  
Lasse Malmqvist ◽  
...  
Keyword(s):  
Optic Disc ◽  
Vessel Density ◽  
Oct Angiography ◽  
Optic Disc Drusen

Συμβολή στη μελέτη των επιπτώσεων της κυστικής ίνωσης στους οφθαλμούς

2021 ◽  
Author(s):  
Παναγιώτης Γιαννακούρας
Keyword(s):  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Break Up ◽  
Nerve Fibre Layer

Σκοπός: H Κυστική Ίνωση αποτελεί την πιο κοινή γενετική διαταραχή στην Καυκάσια φυλή που κληρονομείται με υπολειπόμενο χαρακτήρα και μπορεί να οδηγήσει τελικά στο θάνατο. Προσβάλλει κυρίως τους πνεύμονες. Ο σκοπός της εργασίας αυτής ήταν να μελετηθεί η προσβολή του οφθαλμού σε ασθενείς με Κυστική Ίνωση στον ελληνικό πληθυσμό.Μέθοδος: Πενήντα ενήλικοι ασθενείς με Κυστική Ίνωση και 60 υγιείς εθελοντές αντίστοιχης ηλικίας και φύλου, συμπεριλήφθηκαν στη μελέτη και υποβλήθηκαν σε πλήρη οφθαλμολογικό έλεγχο που περιελάμβανε την αξιολόγηση του χρόνου διάσπασης της δακρυϊκής στιβάδας, τη μέτρηση του πάχους της ωχράς κηλίδας και της στιβάδας των νευρικών ινών του αμφιβληστροειδούς (Macular Thickness and Retinal Nerve Fibre Layer-RNFL-thickness) με τη χρήση Spectral Domain-OCT.Αποτελέσματα: Οι ασθενείς με Κυστική Ίνωση παρουσίασαν στατιστικά μικρότερο πάχος των νευρικών ινών του αμφιβληστροειδούς γύρω από την περιθηλαία περιοχή (median 82 IQR 67-102 vs 92.5 IQR 82-107, p=0.005) και μικρότερο ποσοστό φυσιολογικού χρόνου διάσπασης χρωστικής της δακρυϊκής στιβάδας (56.0% vs 96.7%,p=0.001) σε σχέση με την ομάδα εθελοντών. Όλοι οι ασθενείς με Κυστική Ίνωση με χρόνο διάσπασης χρωστικής μικρότερο από 10 δευτερόλεπτα διεγνώσθησαν με βλεφαρίτιδα κατά τη διάρκεια της οφθαλμολογικής εξέτασης. Η ομάδα των ασθενών που ήταν ομόζυγοι για την πιο γνωστή μετάλλαξη της Κυστικής Ίνωσης, F508del, παρουσίασαν χαμηλότερο πάχος της στιβάδας των νευρικών ινών του αμφιβληστροειδούς γύρω από την περιθηλαία περιοχή, pRNFL thickness (p=0.014) και χαμηλότερο ποσοστό φυσιολογικού χρόνου διάσπασης της χρωστικής στη δακρυϊκή στιβάδα, normal tear Break-Up Time (p=0.001). Επιπλέον ευρήματα, παρόντα μόνο στην ομάδα των ασθενών της Κυστικής Ίνωσης ήταν στικτές αμφιβληστροειδικές αιμορραγίες (4 ασθενείς), ελίκωση των αγγείων (4 ασθενείς), αμφιβήστροειδικές αλλοιώσεις δίκην κοχλίου ή θυσάνου (2 ασθενείς χωρίς διαθλαστικές διαταραχές). Δεν εντοπίστηκαν σημαντικές διαφορές στην αξιολόγηση της οπτικής οξύτητας, στις διαθλαστικές μετρήσεις, στα γωνιοσκοπικά ευρήματα ή στη μέτρηση της ενδοφθάλμιας πίεσης μεταξύ των 2 ομάδων.Συμπεράσματα: Η εργασία αυτή, απ’όσο είμαστε σε θέση να γνωρίζουμε, αποτελεί τη μεγαλύτερη οφθαλμολογική μελέτη ασθενών με Κυστική Ίνωση. Βρέθηκε ότι οι ασθενείς με ΚΙ εμφάνισαν στατιστικά σημαντικά μικρότερο πάχος της στιβάδας των νευρικών ινών του αμφιβληστροειδούς γύρω από την περιθηλαία περιοχή και μικρότερο ποσοστό φυσιολογικών τιμών χρόνου διάσπασης χρωστικής της δακρυϊκής στιβάδας σε σχέση με την ομάδα που αποτέλεσε τους εθελοντές. Υπογραμμίζουμε τη σημασία της προσεκτικής τακτικής οφθαλμολογικής εξέτασης και παρακολούθησης αυτών των ασθενών.

Factors affecting the diagnostic performance of circumpapillary retinal nerve fibre layer measurement in glaucoma

2020 ◽  
pp. bjophthalmol-2020-315985 ◽  
Author(s):  
Damon Wong ◽  
Jacqueline Chua ◽  
Mani Baskaran ◽  
Bingyao Tan ◽  
Xinwen Yao ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Nerve Fibre ◽  
Disease Severity ◽  
Healthy Subjects ◽  
Diagnostic Performance ◽  
Retinal Nerve Fibre Layer ◽  
Automated Perimetry ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Background/aimsTo identify factors that influence the diagnostic performance of circumpapillary retinal nerve fibre layer (RNFL) thickness measurements in the detection of primary open-angle glaucoma (POAG).Methods1592 eyes from 1076 healthy controls and 758 eyes from 502 patients with POAG underwent optical coherence tomography (OCT) imaging to assess RNFL parameters. Visual field (VF) mean deviation (MD) from standard automated perimetry was used to indicate severity in subjects with glaucoma.ResultsRNFL thickness significantly decreased with age (ρ=−0.10 to −0.16, p<0.001) and increased with spherical equivalent (SE) refractive error (ρ=0.23–0.29, p<0.001) in healthy and glaucoma groups but showed a significant reduction with SE (ρ=−0.20, p<0.001) in the temporal RNFL of healthy subjects. RNFL measurements significantly decreased with VF MD (ρ=0.08–0.53, p<0.05) in subjects with POAG. When healthy subjects and subjects with glaucoma were matched to subgroups within a factor, significant differences in area under the curve (AUC) between subgroups were only found with SE AUCs increased significantly with disease severity, particularly in the global, inferior and superior measurements (p<0.001). Overall, the diagnostic performance of the inferior and global RNFL measurements were found to be more resilient to different factors.ConclusionDiagnostic accuracy in glaucoma was influenced by SE but could be mitigated by using controls with similar refractive characteristics. Increasing disease severity led to significantly better diagnostic accuracy. These factors should be considered when using OCT for glaucoma diagnosis in practice.

scholarly journals Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study

2017 ◽  
Vol 102 (5) ◽  
pp. 604-610 ◽  
Author(s):  
Gianni Virgili ◽  
Manuele Michelessi ◽  
Jonathan Cook ◽  
Charles Boachie ◽  
Jennifer Burr ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Nerve Fibre Layer ◽  
Diagnostic Study ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Characteristics Analysis ◽  
Secondary Analyses ◽  
The Uk ◽  
Inferior Quadrant

Background/AimsTo assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma.MethodsSecondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. We used both eyes’ data and logistic regression-based receiver operator characteristics analysis to build a set of models to measure the sensitivity and specificity of the average and inferior quadrant RNFL thickness data of OCT. The reference standard was expert clinician examination including automated perimetry. The main outcome measures were sensitivity at 0.95 specificity and specificity at 0.95 sensitivity and the corresponding RNFL thickness thresholds. We explored the possibility of accuracy improvement by adding measures of within-eye and between-eye variation, scan quality, intraocular pressure (IOP) and age.ResultsGlaucoma was diagnosed in at least one eye in 17% of participants. Areas under the curve were between 0.83 and 0.88. When specificity was fixed at 0.95, the sensitivity was between 0.38 and 0.55, and the highest values were reached with models including the inferior quadrant rather than the average RNFL thickness. Fixing sensitivity at 0.95, the specificity was between 0.36 and 0.58. The addition of age, refractive error, IOP or within-subject variation did not improve the accuracy.ConclusionRNFL thickness data of OCT can be used as a diagnostic test, but accuracy estimates remain moderate even in exploratory multivariable modelling of aiming to improve accuracy.

scholarly journals Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kelvin K. W. Cheng ◽  
Beatrice L. Tan ◽  
Lyndsay Brown ◽  
Calum Gray ◽  
Eleonora Bianchi ◽  
...  
Keyword(s):  
Multivariable Analysis ◽  
Normal Tension Glaucoma ◽  
Retinal Nerve Fibre Layer ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Ganglion Cell Complex ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Avascular Zone

AbstractThe aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests including; intraocular pressure measurement; standard automated perimetry; optical coherence tomography (OCT) measurement of macular ganglion cell complex (mGCC), inner macular thickness (IMT) and circumpapillary retinal nerve fibre layer (cpRNFL); and OCT angiography measurement of pfVD, FAZ perimeter and multispectral fractal dimensions (MSFD). Eyes with more severe glaucoma had significantly thinner mGCC and cpRNFL and lower pfVD. MD decreased by 0.4 dB (95% CI 0.1 to 0.6 dB, P = 0.007) for every 1% decrease in pfVD. Lower MSFD was observed in eyes with lower pfVD and in patients with systemic hypertension. Multivariable analysis, accounting for age and OCTA quality, found lower pfVD remained significantly associated with thinner IMT, thinner mGCC and worse MD but not with MSFD. pfVD was reduced in NTG and was diminished in eyes with worse MD. Macular vessel branching complexity was not related to severity of visual field loss but was lower in patients with systemic hypertension.

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