Factors associated with iron deficiency anaemia among pregnant teenagers in Ashanti Region, Ghana: A hospital-based prospective cohort study

Background Iron Deficiency Anaemia (IDA) is reportedly high in pregnant adults and the causes well studied. However, among pregnant teenagers, the levels and associated factors of IDA are not fully understood. Methods In a prospective cohort study among Ghanaian pregnant teenagers, aged 13–19 years, IDA prevalence and associated factors were investigated. Sociodemographic data, household hunger scale (HHS), lived poverty index (LPI), FAO’s women’s dietary diversity score (WDDS) and interventions received during antenatal care (ANC) were obtained from 416 pregnant teenagers in Ashanti Region, Ghana. Micronutrient intakes using a repeated 24-hour dietary recall, and mid-upper arm circumference (MUAC) were determined and blood samples analysed for haemoglobin (Hb), serum levels of ferritin, prealbumin, vitamin A, total antioxidant capacity (TAC), C-reactive protein (CRP), and zinc protoporphyrin (ZPP). Results Anaemia (Hb cutoff <11.0 g/dL) was 57.1%; deficient systemic supply of iron stores (31.4%), depleted body stores of iron (4.4%), inadequate dietary iron intake (94.5%), and inadequate multiple micronutrient intakes (49.5%), were all notable among study participants. Between-subject effects using Generalized Linear Modelling indicated malaria tablet given at ANC (p = 0.035), MUAC (p = 0.043), ZPP (p<0.001), ZPP/Hb ratio (p<0.001) and depleted body iron stores (DBIS) (p<0.001) to significantly affect Hb levels. Pregnant teenagers with a high ZPP/Hb ratio (OR = 9.7, p<0.001, 95%CI = 6.0–15.8) had increased odds of being anaemic compared to those with normal ZPP/Hb ratio. Participants who were wasted (OR = 1.2, p = 0.543, 95%CI = 0.6–2.3), and those with depleted iron stores (OR = 3.0, p = 0.167, 95%CI = 0.6–14.6) had increased odds of being anaemic. Participants who experienced hunger were close to 3 times more likely (OR = 2.9, p = 0.040, 95%CI = 1.1–7.8) for depleted iron stores, compared to those who did not experience hunger. Also, participants with inadequate multiple micronutrients intakes (OR = 2.6, p = 0.102, 95%CI = 0.8–8.4), and those with low serum levels of ferritin (OR = 3.3, p = 0.291, 95%CI = 0.4–29.2) had increased odds of depleted body iron stores. Conclusions IDA is common among pregnant teenagers and the related factors include malaria tablets given at ANC, maternal hunger, maternal MUAC, a deficient systemic supply of iron, depleted body iron stores, ZPP, and ZPP/Hb ratio. Appropriate interventions are urgently needed to address the causes of IDA among pregnant teenagers.

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Slower response to treatment of iron deficiency anaemia in HIV‐infected pregnant women: a prospective cohort study

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/1471-0528.16671 ◽

2021 ◽

Author(s):

Jennifer C. Hull ◽

Evan M. Bloch ◽

Charlotte Ingram ◽

Robert Crookes ◽

Jenifer Vaughan ◽

...

Keyword(s):

Cohort Study ◽

Iron Deficiency ◽

Pregnant Women ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Iron Deficiency Anaemia ◽

Response To Treatment ◽

Deficiency Anaemia

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A REVIEW ON COMPARITIVE STUDY ON SAFETY AND EFFECTIVENESS OF IV FERRIC CARBOXY MALTOSE VERSUS IRON SUCROSE IN PATIENTS WITH IRON DEFICIENCY ANAEMIA OF CKD

International Journal of Pharmaceutical and Biological Science Archive ◽

10.32553/ijpba.v7i2.123 ◽

2019 ◽

Vol 7 (2) ◽

Author(s):

LAYANA V. S ◽

RANI MANJU ◽

MATHEW GEORGE ◽

LINCY JOSEPH

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Intravenous Iron ◽

Iron Sucrose ◽

Deficiency Anemia ◽

Deficiency Anaemia ◽

Body Iron ◽

Iron Stores

Deficiency of iron is one of the most common nutritional disorders in the society. Iron deficiency anemia is described as decreased production in red blood cells (RBCs) due to low body iron stores.Anemia commonly occurs in people with chronic kidney disease and it might begin to develop in the early stages and tends to worsen as disease progresses. Iron supplementation is mandatory in the majority of patients with renal disease, particularly in those receiving ESA therapy. Treatment with intravenous iron in some clinical situations could present some advantages over oral iron, such as faster and higher increases of hemoglobin (Hb) levels and body iron stores. Some modern formulations of intravenous iron have emerged as a safe and effective alternative for iron deficiency anaemia management. E.g.: iron sucrose. Ferric carboxy maltose is a parenteral iron dextran-free product and the first of the new agents approved for rapid and high-dose replenishment of depleted iron stores. Keywords: Iron deficiency anaemia, chronic kidney disease, hemoglobin, iron sucrose, ferric carboxy maltose

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Iron Deficiency Anemia Among Chinese Pregnant Women: a Multi-center Prospective Cohort Study

Case Medical Research ◽

10.31525/ct1-nct03961074 ◽

2019 ◽

Author(s):

Keyword(s):

Cohort Study ◽

Iron Deficiency ◽

Pregnant Women ◽

Iron Deficiency Anemia ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Deficiency Anemia

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Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽

10.2337/dc16-1295 ◽

2016 ◽

Vol 40 (3) ◽

pp. 346-351 ◽

Cited By ~ 20

Author(s):

Adela Brahimaj ◽

Symen Ligthart ◽

M. Arfan Ikram ◽

Albert Hofman ◽

Oscar H. Franco ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Levels ◽

Incident Type ◽

Incident Type 2 Diabetes

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Stroke-related mortality, disability and associated factors in two regional hospitals in Cameroon: A prospective cohort study

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.119614 ◽

2021 ◽

Vol 429 ◽

pp. 119614

Author(s):

Angwafor Anye ◽

David Ojong ◽

Nkouonlack Cyrille ◽

Wepnyu Njamnshi ◽

Leonard Ngarka ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Associated Factors ◽

Regional Hospitals ◽

Related Mortality

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Dynamics of Interleukin-10 Levels in Chronic Rhinosinusitis with/without Allergy

The Indonesian Biomedical Journal ◽

10.18585/inabj.v7i3.182 ◽

2015 ◽

Vol 7 (3) ◽

pp. 163

Author(s):

Abdul Qadar Punagi ◽

Sutji Pratiwi Rahardjo

Keyword(s):

Cohort Study ◽

Chronic Rhinosinusitis ◽

Inflammatory Cytokines ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Treatment Approach ◽

Specific Treatment ◽

Serum Levels ◽

Interleukin 10 ◽

Persistent Problem

BACKGROUND: Rhinosinusitis occurs when the lining of the nasal and sinuses gets inflamed, infected or irritated, become swollen, and create extra mucus, the swollen lining may also interfere with drainage of mucus. Chronic rhinosinusitis (CRS) is a more persistent problem that requires a specific treatment approach. Aim of this study was to determine changes in interleukin (IL)-10 as an anti-inflammatory cytokines in allergic and non-allergic CRS at Makassar. METHODS: A prospective cohort study was designed to assess the level of IL-10 for three times during two weeks of therapy. Medication of Cefadroxil 500 mg 2x1, Pseudoephedrine 30 mg 2x1, Terfenadine 40 mg 2x1 and Methylprednisolone 4 mg 3x1, was conducted during two weeks for 13 subjects in allergic CRS group and 12 subjects in non-allergic CRS group. Results were statistically analyzed with student t-test and paired t-test.RESULTS: The changes in levels of IL-10 in allergic CRS group were increased, but not significant (5.293 to 5.769, p=0.058), and in non-allergic CRS group were decreased, but not significant (6.125 to 5.475, p=0.103). CONCLUSION: The serum levels of IL-10 were not significant increased in allergic CRS group and not significant decreased in non-allergic CRS group. KEYWORDS: interleukin-10, chronic rhinosinusitis, allergy, cefadroxil, pseudoephedrine, terfenadine, methylprednisolone

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Severe iron deficiency anaemia

Emergencies in Gastroenterology and Hepatology ◽

10.1093/med/9780199231362.003.0003 ◽

2013 ◽

pp. 35-42

Author(s):

Daniel Marks ◽

Marcus Harbord

Keyword(s):

Chronic Disease ◽

Iron Deficiency ◽

Blood Loss ◽

Iron Deficiency Anaemia ◽

Parasite Load ◽

Deficiency Anaemia ◽

Iron Stores ◽

Menopausal Women ◽

Post Menopausal ◽

Developed World

Implication of iron deficiency Causes of iron deficiency Overt or occult bleeding Diagnosing iron deficiency Presentation and investigations Treatment Anaemia of chronic disease In the developed world, the commonest cause of iron deficiency anaemia (IDA) and its prelude iron deficiency is menstrual blood loss. Worldwide, hookworm infection is prevalent and causes IDA in those with heavy parasite load. About 4% of men/post-menopausal women have iron deficiency, and 1–2% have related IDA. Iron deficiency rises to ~20% in pre-menopausal women (remainder often have considerably reduced iron stores)....

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Safety and Efficacy of Intravenous Ferric Carboxy Maltose in Iron Deficiency Anaemia During Postpartum Period

Journal of Nepal Health Research Council ◽

10.3126/jnhrc.v15i3.18841 ◽

2018 ◽

Vol 15 (3) ◽

pp. 208-211 ◽

Cited By ~ 2

Author(s):

Vineet Mishra ◽

Priyankur Roy ◽

Khushali Gandhi ◽

Sumesh Choudhary ◽

Rohina Aggarwal ◽

...

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Binding Capacity ◽

World Health Organisation ◽

World Health ◽

Serious Adverse Events ◽

Deficiency Anaemia ◽

Iron Stores ◽

Mild Anaemia ◽

High Doses

Background: Iron deficiency is the commonest treatable cause of postpartum anaemia. Parenteral iron therapy results in faster and higher replenishment of iron stores and correction of haemoglobin levels with better compliance. Ferric Carboxy Maltose is an effective and a safe option which can be administered intravenously in single total correction dose without any serious adverse effects.The study was done to evaluate the efficacy and safety of Ferric Carboxy Maltose in the treatment of iron deficiency anaemia in post-natal patients.Methods: It was an open, single arm study including 615 women with diagnosis of Iron deficiency anaemia and haemoglobin (Hb) levels between 4gm% and 11gm% from January 2013 to December 2016. Intravenous Ferric Carboxy Maltose(500-1500mg) was administered and the improvement in haemoglobin levels and iron stores were assessed after three weeks of total dose infusion.Results: Out of the 615 women, 595 women were included in the analysis. Most of the women were in the age group of 27-30 years. Most of the women had mild anaemia as per World Health Organisation guidelines. Mean hemoglobin levels significantly increased over a period of three weeks after Ferric Carboxy Maltose administration. Other parameters like total iron binding capacity, Ferritin and Iron also had a significant improvement after Ferric Carboxy Maltose administration. No serious adverse events were observed after Ferric Carboxy Maltose.Conclusions: Intravenous Ferric Carboxy Maltose was an effective and a safe treatment option for iron deficiency anaemia and has an advantage of single administration of high doses without serious adverse effects.

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