scholarly journals Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252588
Author(s):  
Marta Wysocka-Mincewicz ◽  
Joanna Gołębiewska ◽  
Marta Baszyńska-Wilk ◽  
Andrzej Olechowski ◽  
Aleksandra Byczyńska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Nerve Conduction ◽  
Peripheral Nerves ◽  
Signs And Symptoms ◽  
Sensory Nerves ◽  
Ganglion Cell Complex ◽  
Potential Amplitude ◽  
Motor Nerves ◽  
F Wave

Aim To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS). Material and methods 50 adolescents with T1D without any signs and symptoms of diabetic retinopathy and neuropathy (mean age 16.92±1.6 years, diabetes duration 6.88 ±4.34years) were included. In OCTA capillary plexuses superficial (SCP) and deep (DCP) vessel density: whole, foveal and parafoveal, ganglion cell complex (GCC), loss volume focal (FLV) and global loss volume (GLV) were analyzed in relation to NCS parameters (motor nerves median and tibial potential amplitude (CMAP), velocity (CV), distal latency (DML) and F wave and sensory nerves median and sural potential amplitude (SNAP), CV and distal latency (DSL). Results We detected the correlations between median sensory SNAP and GCC (r = -0.3, p <0.04), motor nerves tibial DML and CV and FLV (respectively r = -0.53, p<0.001, and r = -0.34, p<0.05), and median DML and GLV (r = 0.47, p<0.001). Vessel densities were related to changes in motor nerves tibial velocity (whole SCP r = 0.43, p <0.01, parafoveal SCP r = 0.41, p <0.01), CMAP (parafoveal SCP r = -0.35, p<0.03), median DML (whole DC r = 0.36, p<0.03, foveal DCP r = 0.37, p<0.02) and in sensory median SNAP (whole SCP r = -0.31, p<0.05). Conclusions In adolescents with T1D without diabetic neuropathy and retinopathy we detected associations between NCS and OCT and OCTA parameters, regarding decreased GCC and density of superficial and deep vessel plexuses in relation to DML and CV and amplitudes of sensory and motor potential.

Point-of-Care Nerve Conduction for the Identification of Neuropathy in Older Adults with Type 1 Diabetes

2017 ◽  
Vol 41 (5) ◽  
pp. S63
Author(s):  
Daniel Scarr ◽  
Leif E. Lovblom ◽  
Nancy Cardinez ◽  
Andrej Orszag ◽  
Mohammed A. Farooqi ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Nerve Conduction ◽  
Point Of Care

Very Early Neurophysiological Study in Guillain-Barre Syndrome

2018 ◽  
Vol 80 (1-2) ◽  
pp. 100-105 ◽  
Author(s):  
Jiaoting Jin ◽  
Fangfang Hu ◽  
Xing Qin ◽  
Xuan Liu ◽  
Min Li ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Tibial Nerve ◽  
Early Stage ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Sensory Nerves ◽  
Motor Nerve Conduction ◽  
Abnormal Rate ◽  
Motor Nerves

Purpose: The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. Methods: We prospectively recruited patients with a diagnosis of GBS discharged from First Affiliated Hospital of Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3 groups according to the onset of symptoms to electromyography examination interval (OEI). The neurophysiological findings were carried out using standard procedures. All patients were examined by the same experienced neurophysiologist. Results: There were not significant group differences in abnormal rate, distal motor latency (DML), motor nerve conduction velocity (MNCV), F response (FR), compound muscle action potential (CMAP), conduction block (CB), sensory nerve action potential (SNAP), and sensory nerve conduction velocity among OEI ≤4 days, 4< OEI ≤10 days, and OEI > 10 days groups. Motor nerves were more affected than sensory nerves in neurophysiological presentation in very early stage patients. The difference of motor nerves and sensory nerves was statistically significant in lower limbs, but was not in upper limbs. In motor nerve conduction studies, the abnormal rate of DML, MNCV, FR, CB was more common seen in ulnar and peroneal nerve than median and tibial nerve, the abnormal rate of CMAP was the same in ulnar, median, peroneal and tibial nerve. In sensory nerve conduction studies, the abnormal rate of ulnar nerve and median nerve was higher than the superficial peroneal nerve and sural nerve. The OEI was not correlated with the SNAP decrease rate of median (r = 0.10, p = 0.23) and ulnar (r = 0.26, p = 0.06) but was statistically correlated with sural SNAP decrease rate (r = 0.29, p = 0.04). The sural-sparing pattern phenomenon was the most commonly discovered phenomenon in very early stage patients (OEI ≤4 days), followed by patients with 4< OEI ≤10 days, ultimately found in patients with OEI > 10 days. Conclusions: We suggest performing neurophysiological examination as soon as possible for suspected GBS patients, particularly focusing on multi-spots inspection of ulnar and peroneal nerves, and paying close attention to sural-sparing patterns.

scholarly journals Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes

2019 ◽  
Vol 32 (8) ◽  
pp. 796-803 ◽  
Author(s):  
Georgios Ponirakis ◽  
Ioannis N Petropoulos ◽  
Uazman Alam ◽  
Maryam Ferdousi ◽  
Omar Asghar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Nerve Conduction ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Fiber Density ◽  
Converting Enzyme Inhibitors ◽  
Perception Threshold ◽  
Pressure Lowering

Abstract BACKGROUND Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease-modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with type 1 diabetes mellitus (T1DM). METHODS Subjects with T1DM (n = 70) and controls (n = 78) underwent a comprehensive assessment of DPN. RESULTS Hypertension was present in 40 of 70 T1DM subjects and 20 of 78 controls. Hypertension was associated with abnormal nerve conduction parameters (P = 0.03 to <0.001), increased vibration perception threshold (P = 0.01) and reduced corneal nerve fiber density and length (P = 0.02) in subjects with T1DM. However, after adjusting for confounding factors only tibial compound motor action potential and nerve conduction velocity were associated with hypertension (P = 0.03) and systolic blood pressure (P < 0.01 to <0.0001). Hypertension had no effect on neuropathy in subjects without diabetes. CONCLUSIONS This study shows that hypertension is associated with impaired nerve conduction in T1DM. It supports previous small trials showing that angiotensin-converting enzyme inhibitors improve nerve conduction and advocates the need for larger clinical trials with blood pressure lowering agents in DPN.

scholarly journals Explanatory models of families of children with type 1 diabetes mellitus

2020 ◽  
Vol 73 (suppl 4) ◽  
Author(s):  
Isa Ribeiro de Oliveira Dantas ◽  
Rhyquelle Rhibna Neris ◽  
Márcia Maria Fontão Zago ◽  
Manoel Antônio dos Santos ◽  
Lucila Castanheira Nascimento
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Methodological Approach ◽  
Signs And Symptoms ◽  
Explanatory Models ◽  
Blood Glucose Monitoring ◽  
Effective Control ◽  
Care Needs

ABSTRACT Objectives: to analyze how children with type 1 diabetes mellitus and their families explain the pathology, based on their understanding of the factors related to the discovery of diabetes, the etiology, treatment, and prognosis of the disease. Methods: qualitative methodological approach, based on medical anthropology and the narrative method. In-depth interviews were conducted with 12 families of children with type 1 diabetes mellitus attending follow-up consultations at a specialized center. The statements were subjected to inductive thematic analysis. Results: the explanatory models identified describe the families search for the clarification of the signs and symptoms that the child had. Faced with the disease, families reorganized themselves to meet new health care needs of children, such as adequate nutrition, physical exercise, and blood glucose monitoring. Final Considerations: knowing the explanatory models allows the understanding of how families give meaning to the child’s illness, favoring daily nursing care and an effective control of the disease.

scholarly journals Validity of a point-of-care nerve conduction device for polyneuropathy identification in older adults with diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0196647 ◽  
Author(s):  
Daniel Scarr ◽  
Leif E. Lovblom ◽  
Nancy Cardinez ◽  
Andrej Orszag ◽  
Mohammed A. Farooqi ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Nerve Conduction ◽  
Point Of Care ◽  
Canadian Study

scholarly journals Effect of omega-3 supplementation on neuropathy in type 1 diabetes

Neurology ◽  
2017 ◽  
Vol 88 (24) ◽  
pp. 2294-2301 ◽  
Author(s):  
Evan J.H. Lewis ◽  
Bruce A. Perkins ◽  
Leif E. Lovblom ◽  
Richard P. Bazinet ◽  
Thomas M.S. Wolever ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Nerve Conduction ◽  
Sensory Function ◽  
Omega 3 ◽  
Open Label ◽  
Pufa Supplementation ◽  
Corneal Confocal Microscopy ◽  
Seal Oil

Objective:To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes mellitus (T1DM).Methods:Individuals with T1DM and evidence of DSP as determined by a Toronto Clinical Neuropathy Score ≥1 were recruited to participate in a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (10 mL·d−1; 750 mg eicosapentaenoic acid, 560 mg docosapentaenoic acid, and 1,020 mg docosahexaenoic acid) for 1 year. The primary outcome was the 1-year change in corneal nerve fiber length (CNFL) measured by in vivo corneal confocal microscopy, with sensory and nerve conduction measures as secondary outcomes.Results:Forty participants (53% female), aged 48 ± 14 years, body mass index 28.1 ± 5.8 with diabetes duration of 27 ± 18 years, were enrolled. At baseline, 23 participants had clinical DSP and 17 did not. Baseline CNFL was 8.3 ± 2.9 mm/mm2 and increased 29% to 10.1 ± 3.7 mm/mm2 (p = 0.002) after 12 months of supplementation. There was no change in nerve conduction or sensory function.Conclusions:Twelve months of ω-3 supplementation was associated with increase in CNFL in T1DM.ClinicalTrials.govidentifier:NCT02034266.Classification of evidence:This study provides Class IV evidence that for patients with T1DM and evidence of DSP, 12 months of seal oil omega-3 supplementation increases CNFL.

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