scholarly journals Antibody Inhibition of a Viral Type 1 Interferon Decoy Receptor Cures a Viral Disease by Restoring Interferon Signaling in the Liver

2012 ◽  
Vol 8 (1) ◽  
pp. e1002475 ◽  
Author(s):  
Ren-Huan Xu ◽  
Daniel Rubio ◽  
Felicia Roscoe ◽  
Tracy E. Krouse ◽  
Mary Ellen Truckenmiller ◽  
...  
Keyword(s):  
Viral Disease ◽  
Interferon Signaling ◽  
Type 1 Interferon ◽  
Decoy Receptor ◽  
Viral Type ◽  
Antibody Inhibition

scholarly journals Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes

Cell ◽  
2016 ◽  
Vol 164 (3) ◽  
pp. 349-352 ◽  
Author(s):  
Cherie T. Ng ◽  
Juan L. Mendoza ◽  
K. Christopher Garcia ◽  
Michael B.A. Oldstone
Keyword(s):  
Interferon Signaling ◽  
Type 1 Interferon

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

2014 ◽  
Vol 35 (5) ◽  
pp. 1012-1023 ◽  
Author(s):  
Juliet M. Taylor ◽  
Myles R. Minter ◽  
Andrew G. Newman ◽  
Moses Zhang ◽  
Paul A. Adlard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Interferon Signaling ◽  
Type 1 Interferon

scholarly journals Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in COVID-19 Patients

2021 ◽  
Author(s):  
Elana R Shaw ◽  
Lindsey B Rosen ◽  
Aristine Cheng ◽  
Kerry Dobbs ◽  
Ottavia M Delmonte ◽  
...  
Keyword(s):  
Temporal Dynamics ◽  
Viral Disease ◽  
Healthy Individuals ◽  
Neutralization Activity ◽  
Type 1 Interferon

Abstract Binding levels and neutralization activity of anti-type 1 interferon (T1IFN) autoantibodies peaked during acute COVID-19 and markedly decreased thereafter. Most patients maintained some ability to neutralize T1IFN into convalescence despite lower levels of binding IgG. Identifying these autoantibodies in healthy individuals before they develop critical viral disease may be challenging.

scholarly journals Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein–mediated blockade of type 1 interferon signaling

2017 ◽  
Vol 292 (48) ◽  
pp. 19752-19766 ◽  
Author(s):  
Kosuke Oda ◽  
Takashi Oda ◽  
Yasuyuki Matoba ◽  
Mamoru Sato ◽  
Takashi Irie ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Sendai Virus ◽  
Interferon Signaling ◽  
C Protein ◽  
Type 1 Interferon ◽  
Virus C

Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-1010
Author(s):  
Ann Elisabet Østvik ◽  
Tarjei Dahl Svendsen ◽  
Atle van Beelen Granlun ◽  
Berit Doseth ◽  
Ingunn Bakke ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Epithelial Cells ◽  
Bowel Disease ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Interferon Signaling ◽  
Type 1 Interferon ◽  
Active Inflammatory Bowel Disease ◽  
Inflammatory Bowel
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