THE LONG-TERM IMPACT OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) ON PULMONARY FUNCTION, EXERCISE CAPACITY, AND QUALITY OF LIFE IN A COHORT OF SURVIVORS

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.

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Prophylactic Total Gastrectomy: a Prospective Cohort Study of Long-Term Impact on Quality of Life

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-016-3287-8 ◽

2016 ◽

Vol 20 (12) ◽

pp. 1950-1958 ◽

Cited By ~ 11

Author(s):

Jennifer Muir ◽

Melyssa Aronson ◽

Mary-Jane Esplen ◽

Aaron Pollett ◽

Carol J. Swallow

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Total Gastrectomy ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Long Term Impact ◽

Prophylactic Total Gastrectomy

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Antibiotic treatment of exacerbations of COPD in general practice: long-term impact on healthrelated quality of life

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s8732 ◽

2010 ◽

pp. 11 ◽

Cited By ~ 3

Author(s):

Miravitlles

Keyword(s):

Quality Of Life ◽

General Practice ◽

Antibiotic Treatment ◽

Long Term Impact ◽

Healthrelated Quality Of Life

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Early postoperative complications have long-term impact on quality of life after restorative proctocolectomy

Medicine ◽

10.1097/md.0000000000003966 ◽

2016 ◽

Vol 95 (27) ◽

pp. e3966 ◽

Cited By ~ 9

Author(s):

Andrew McCombie ◽

Yun Lee ◽

Rutvik Vanamala ◽

Richard Gearry ◽

Frank Frizelle ◽

...

Keyword(s):

Quality Of Life ◽

Postoperative Complications ◽

Restorative Proctocolectomy ◽

Early Postoperative Complications ◽

Long Term Impact

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Does allogeneic stem cell transplantation in survivors of pediatric leukemia impact regular physical activity, pulmonary function, and exercise capacity?

Molecular and Cellular Pediatrics ◽

10.1186/s40348-021-00127-7 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Katharina Ruf ◽

Alaa Badran ◽

Céline Siauw ◽

Imme Haubitz ◽

Paul-Gerhardt Schlegel ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Stem Cell ◽

Oxygen Uptake ◽

Stem Cell Transplantation ◽

Pulmonary Function ◽

Cell Transplantation ◽

Exercise Capacity ◽

Peak Oxygen Uptake

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

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The risks and benefits of yoga for patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215519860551 ◽

2019 ◽

Vol 33 (12) ◽

pp. 1847-1862 ◽

Cited By ~ 2

Author(s):

Holger Cramer ◽

Heidemarie Haller ◽

Petra Klose ◽

Lesley Ward ◽

Vincent CH Chung ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Exercise Capacity ◽

Meta Analysis ◽

Chronic Obstructive ◽

Controlled Trials ◽

Obstructive Pulmonary Disease ◽

Randomized Controlled ◽

Mean Differences

Objectives: To determine the effectiveness and safety of yoga interventions on disease symptoms, quality of life and function in patients diagnosed with chronic obstructive pulmonary disease (COPD). Data sources: Medline/PubMed, Scopus, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched through 6 June 2019. Review methods: Randomized controlled trials assessing the effects of yoga on quality of life, dyspnea, exercise capacity, and pulmonary function (FEV1) in patients with COPD were included. Safety was defined as secondary outcome. Mean differences (MD) and standardized mean differences (SMD) with 95% confidence intervals (CIs) were computed. Risk of bias was assessed using the Cochrane tool. Results: Eleven randomized controlled trials with a total of 586 patients were included. Meta-analysis revealed evidence for effects of yoga compared to no treatment on quality of life on the COPD Assessment Test (MD = 3.81; 95% CI = 0.97 to 6.65; P = 0.009, I2 = 70%), exercise capacity assessed by the 6-minute walk test (MD = 25.53 m; 95% CI = 12.16 m to 38.90 m; P = 0.001, I2 = 0%), and pulmonary function assessed by FEV1 predicted (MD = 3.95%; 95% CI = 2.74% to 5.17%; P < 0.001, I2 = 0%). Only the effects on exercise capacity and pulmonary function were robust against methodological bias. Effects were only present in breathing-focused yoga interventions but not in interventions including yoga postures. Adverse events were reported infrequently. Conclusion: This meta-analysis found robust effects of yoga on exercise capacity and pulmonary function in patients with COPD. Yoga, specifically yoga breathing techniques, can be an effective adjunct intervention for patients with COPD. Yoga’s safety needs to be assessed in more depth in future studies.

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