The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

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The risks and benefits of yoga for patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215519860551 ◽

2019 ◽

Vol 33 (12) ◽

pp. 1847-1862 ◽

Cited By ~ 2

Author(s):

Holger Cramer ◽

Heidemarie Haller ◽

Petra Klose ◽

Lesley Ward ◽

Vincent CH Chung ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Exercise Capacity ◽

Meta Analysis ◽

Chronic Obstructive ◽

Controlled Trials ◽

Obstructive Pulmonary Disease ◽

Randomized Controlled ◽

Mean Differences

Objectives: To determine the effectiveness and safety of yoga interventions on disease symptoms, quality of life and function in patients diagnosed with chronic obstructive pulmonary disease (COPD). Data sources: Medline/PubMed, Scopus, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched through 6 June 2019. Review methods: Randomized controlled trials assessing the effects of yoga on quality of life, dyspnea, exercise capacity, and pulmonary function (FEV1) in patients with COPD were included. Safety was defined as secondary outcome. Mean differences (MD) and standardized mean differences (SMD) with 95% confidence intervals (CIs) were computed. Risk of bias was assessed using the Cochrane tool. Results: Eleven randomized controlled trials with a total of 586 patients were included. Meta-analysis revealed evidence for effects of yoga compared to no treatment on quality of life on the COPD Assessment Test (MD = 3.81; 95% CI = 0.97 to 6.65; P = 0.009, I2 = 70%), exercise capacity assessed by the 6-minute walk test (MD = 25.53 m; 95% CI = 12.16 m to 38.90 m; P = 0.001, I2 = 0%), and pulmonary function assessed by FEV1 predicted (MD = 3.95%; 95% CI = 2.74% to 5.17%; P < 0.001, I2 = 0%). Only the effects on exercise capacity and pulmonary function were robust against methodological bias. Effects were only present in breathing-focused yoga interventions but not in interventions including yoga postures. Adverse events were reported infrequently. Conclusion: This meta-analysis found robust effects of yoga on exercise capacity and pulmonary function in patients with COPD. Yoga, specifically yoga breathing techniques, can be an effective adjunct intervention for patients with COPD. Yoga’s safety needs to be assessed in more depth in future studies.

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Impaired pulmonary function and its association with clinical outcomes, exercise capacity and quality of life in children with congenital heart disease.

Archives of Cardiovascular Diseases Supplements ◽

10.1016/j.acvdsp.2019.09.306 ◽

2020 ◽

Vol 12 (1) ◽

pp. 153

Author(s):

H. Abassi ◽

A. Gavotto ◽

M.C. Picot ◽

H. Bertet ◽

S. Matecki ◽

...

Keyword(s):

Quality Of Life ◽

Congenital Heart Disease ◽

Heart Disease ◽

Pulmonary Function ◽

Clinical Outcomes ◽

Exercise Capacity ◽

Congenital Heart ◽

Impaired Pulmonary Function

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Persistently Reduced Pulmonary Function and Quality of Life in Patients With Mild COVID-19 One Year After Discharge: a Cohort Study

10.21203/rs.3.rs-837394/v1 ◽

2021 ◽

Author(s):

Han Zhang ◽

Yi Peng ◽

Pengwei Hou ◽

Zhu Chen ◽

Guoqiang Xing ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Exercise Capacity ◽

Short Form ◽

Normal Population ◽

Depression Scale ◽

Post Discharge ◽

The Mean ◽

One Year

Abstract Purpose The epidemiological and clinical features, pathogenesis, and complications of patients with COVID-19 in the acute phase have been well described, but the long-term prognosis and rehabilitation of the patients remain largely unknown.Methods 39 COVID-19 patients were followed up at 3, 6, and 12 months after discharge. The mental health, pulmonary function, exercise capacity, and quality of life were assessed by Self-Depression Scale and the Self Anxiety Scale, pulmonary function test, 6MWT, 36-Item Short-Form, respectively. Results Total 33 survivors completed the assessment, 40.8 ± 0.8 years, body mass index= 22.7 ±1.3 kg/m2. The length of hospital stays was 19.6 ± 6.6 d. One year after discharge, the mean scores of SDS and SAS showed decreasing trends from 3-months to 12-months post-discharge. 6 patients (18.2%) had FVC <80% of the predicted value, 12 patients (36.4%) had FEV1 <80% of the predicted value. And 9 (27.3%), 3 (9.1%), and 2 (6.1%) of the patients showed reduced FEF25, FEF50, and FEF75 (<70% expected values), respectively. The mean 6MWD values increased significantly from 397±25.4 m at 3-months to 514±40.8 m at 12-months.Conclusions the impaired pulmonary function in mild COVID-19 survivors was noted after 12 months discharging from hospital. The exercise capacity, mental status, and health status were lower than those of the normal population.

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Severe Acute Respiratory Syndrome, Pulmonary Function Tests, and Quality of Life

CHEST Journal ◽

10.1378/chest.128.3.1088 ◽

2005 ◽

Vol 128 (3) ◽

pp. 1088-1089 ◽

Cited By ~ 2

Author(s):

Alejandro C. Arroliga ◽

Enrique Diaz-Guzman ◽

Herbert P. Wiedemann

Keyword(s):

Quality Of Life ◽

Severe Acute Respiratory Syndrome ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Function Tests

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Effects of Physical Exercises on Pulmonary Rehabilitation, Exercise Capacity, and Quality of Life in Children with Asthma: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5104102 ◽

2021 ◽

Vol 2021 ◽

pp. 1-12

Author(s):

YiRan Liu ◽

Yan Zhao ◽

Fang Liu ◽

Lin Liu

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Exercise Capacity ◽

Bronchial Asthma ◽

Vital Capacity ◽

Meta Analysis ◽

Current Evidence ◽

Children With Asthma ◽

Expiratory Flow

Objective. This study aimed to systematically evaluate the effect of exercise on pulmonary function, exercise capacity, and quality of life in children with bronchial asthma. Methods. A comprehensive search was performed using PubMed, Cochrane Library, Web of Science, EBSCO, CNKI, and Wanfang Data Knowledge Service platform to identify any relevant randomized controlled trials (RCTs) published from inception to April 2021. The Cochrane risk of the bias tool was utilized to evaluate the methodological quality of the included studies, and RevMan 5.3 was applied to perform data analyses. Results. A total of 22 RCTs involving 1346 patients were included. The results of the meta-analysis showed that exercise had significant advantages in improving lung function and exercising capacity and quality of life in children with asthma compared with conventional treatment, such as the forced vital capacity to predicted value ratio (SMD = 0.27; 95% CI: 0.13, 0.40, and P < 0.0001 ), the peak expiratory flow to predicted value ratio (MD = 4.53; 95% CI: 1.27, 7.80, and P = 0.007 ), the 6-minute walk test (MD = 110.65; 95% CI: 31.95, 189.34, and P = 0.006 ), rating of perceived effort (MD = −2.28; 95% CI: −3.21, −1.36, and P < 0.0001 ), and peak power (MD = 0.94; 95% CI: 0.37, 1.52, and P = 0.001 ) on exercise capacity and pediatric asthma quality of life questionnaire (MD = 1.28; 95% CI: 0.60, 1.95, and P = 0.0002 ) on quality of life. However, no significant difference was observed in the forced expiratory flow between 25% and 75% of vital capacity P = 0.25 and the forced expiratory volume at 1 second to predicted value ratio P = 0.07 . Conclusions. Current evidence shows that exercise has a certain effect on improving pulmonary function recovery, exercise capacity, and quality of life in children with bronchial asthma. Given the limitation of the number and quality of included studies, further research and verification are needed to guide clinical application.

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Efficacy and Safety of Jin-Shui Huan-Xian Granule for Idiopathic Pulmonary Fibrosis: Study Protocol for a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

10.21203/rs.3.rs-429927/v1 ◽

2021 ◽

Author(s):

Shu-guang Yang ◽

Xue-qing Yu ◽

Jiansheng Li ◽

Yang Xie ◽

Wei Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Pulmonary Function ◽

Exercise Capacity ◽

Control Group ◽

Double Blind ◽

Double Blind Placebo ◽

Acute Exacerbations

Abstract Background Idiopathic pulmonary fibrosis is a critical disease with poor prognosis. Although different studies have been conducted for the treatment of idiopathic pulmonary fibrosis, limited treatments are available. Jin-shui Huan-xian granule, which is a Chinese medicine herbal compound, has shown a promising efficacy in reducing frequencies of acute exacerbations, improving exercise capacity the quality of life of patients for idiopathic pulmonary fibrosis. Subjects and Methods: This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 312 idiopathic pulmonary fibrosis patients will be enrolled and randomly allocated to one of the two groups with 1:1. After a 2-week washout period, 52-week treatment will also be performed for all the patients. Patients in experimental group will be given Jin-shui Huan-xian granule with Jin-shui Huan-xian placebo for control group. Outcome measures including acute exacerbations, pulmonary function, dyspnea, exercise capacity, quality of life will be evaluated in this study. Discussion Based on our previous study, it is hypothesized that JHG will reduce the acute exacerbations, improve exercise capacity, pulmonary function, quality of life, delay the disease progression-free. High-level evidence-based support for TCM in IPF will also be obtained in this study. Trial registration: http:www.clinicaltrials.gov : NCT04187690. Register data: December 11, 2019.

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Effect of Baduanjin on pulmonary rehablitation in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial (Preprint)

10.2196/preprints.29975 ◽

2021 ◽

Author(s):

Xuan Chen ◽

Cuiping Fu ◽

Xiongbiao Wang ◽

Meng Sun ◽

Wei Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Exercise Capacity ◽

Pulmonary Rehabilitation ◽

Controlled Trial ◽

Training Group ◽

Control Group ◽

Copd Patients ◽

Respiratory Training

BACKGROUND Baduanjin has been applied in health and rehabilitation and gained a growing number of practitioners both in home and abroad.To explore the effect of home based and video guided PR training, our research determined to evaluate Baduanjin on moderate COPD patients and explore its synergy effect with IMT in inducing improvement in pulmonary function, exercise capacity and quality of life. OBJECTIVE We cooperated Baduanjin as a pulmonary rehabilitation intervention for patients with moderate COPD. We evaluated its efficiency on pulmonary function, exercise capacity, quality of life in moderate COPD patients. METHODS This was a multi-centered, prospective, randomized controlled trial. Moderate COPD patients were collected from ten hospitals in Shanghai. After a two-week run-in period, all eligible participants were randomly assigned into Baduanjin training group, Tri-Ball® Respiratory training group, Baduanjin combined with respiratory training group and control group. The outcome assessments were conducted at four time points, namely at the 4th week and 8th week during the intervention, after 12-week pulmonary rehabilitation program and 3-month follow up. RESULTS A total of 240 participants were recruited in this study. 217 moderate COPD patients were analyzed in this study. After 12-week PR intervention, improvement was noticed in pulmonary function (FEV1%), exercise capacity (6MWD) and quality of life (CAT, SGRQ and T.C.M score) in Baduanjin training group when compared to the control group (P<0.05). Combining Baduanjin with additional inspiratory muscle training exerted better result than Banduanjin or inrespiratory muscle training alone (P<0.05). Improved performances after 12-week PR intervention were maintained after 3-month follow up in this research. Compared with the control group, drastically more percentage of participants with mMRC≤2 in combination training group was observed (mMRC≤2, 55(100%) vs 44(83.02%); mMRC＞2, 0(0%) vs 9 (16.98%), P＜0.01). CONCLUSIONS The results of this trial suggested that, Baduanjin training, as a simple daily pulmonary rehabilitation maneuver, could prevent the deterioration of pulmonary function in COPD patients and associated with improvement in exercise capacity and quality of life. CLINICALTRIAL The study protocol has been registered with the Clinical Trial Registry (NCT03892629).

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