scholarly journals PENGGUNAAN BAHAN ACUAN BERSERTIFIKAT OYSTER TISSUE 1566b SEBAGAI INTERNAL QUALITY CONTROL UNTUK MENENTUKAN KADAR TIMBAL TOTAL DALAM TEPUNG IKAN MARLIN DENGAN ELECTROTHERMAL ATOMIC ABSORPTION SPECTROMETRY

2015 ◽  
Vol 17 (2) ◽  
pp. 131-137
Author(s):  
Willy Cahya Nugraha ◽  
Yohanes Susanto Ridwan
Keyword(s):  
Quality Control ◽  
Reference Materials ◽  
Certified Reference Materials ◽  
Electrothermal Atomic Absorption Spectrometry ◽  
Absorption Spectrometry ◽  
Lead Content ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Oyster Tissue ◽  
High Level

Lead is widely knows as one of the harmful pollutants for humans. Contaminated fishery built by lead may endanger the consumption body. Therefore, contamination monitoring for the fishery products is necessary to be conducted. To ensure the validity of data, Oyster Tissue 1566b certified reference material was used as Internal Quality Control. Marlin fish powder and certified reference materials were analyzed with the same method, personnel, duration or time, equipment and environmental conditions. As the results, it was found that the lead contained in CRM was 0.306 mg.kg-1 with 11.9 % rsd, which is within range of lead content in  the certificate. The method was applied for Marlin Fish. Lead content obtained in this study (1.821 mg.kg-1 with 11.06 % rsd) can be reported with high level of confidence.Keywords: Lead, Certified Reference Materials, Marlin fish

Quality control as a fundamental institute of medical activities (review of literary sources)

2021 ◽  
pp. 39-48
Author(s):  
Larisa Arkadyevna Karaseva ◽  
Tatyana Vladimirovna Bessonova
Keyword(s):  
Quality Of Life ◽  
Quality Control ◽  
Medical Care ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Quality And Safety ◽  
Professional Activities ◽  
Literary Sources ◽  
High Level

The aim of the study, analyze and evaluate the quality control and safety of medical activities carried out in medical organizations. Results: the essence of the concept of quality control in the field of medical care was determined, criteria for assessing the quality of medical activities were identified, the main aspects of developing a program for internal quality control and safety of medical activities were characterized, key risks existing in medical activities were identified, directions for improving the quality and safety of professional activities of medical workers. Conclusion: modern approaches to the organization of quality control and safety of medical activities make it possible to ensure a high level of medical care provided to the population and improve the quality of life of the population as a whole.

scholarly journals Estimate of Uncertainty of Measurement from a Single-Laboratory Validation Study: Application to the Determination of Lead in Blood

2004 ◽  
Vol 50 (8) ◽  
pp. 1396-1405 ◽  
Author(s):  
Marina Patriarca ◽  
Marco Castelli ◽  
Federica Corsetti ◽  
Antonio Menditto
Keyword(s):  
Reference Materials ◽  
Certified Reference Materials ◽  
Electrothermal Atomic Absorption Spectrometry ◽  
Absorption Spectrometry ◽  
Environmental Pollutant ◽  
The European Union ◽  
Lead In Blood ◽  
Method Performance ◽  
Target Values

Abstract Background: Lead is an environmental pollutant, and human exposure is assessed by monitoring lead concentrations in blood. Because the main source of environmental exposure has been the use of leaded gasoline, its phase-out has led to decreased lead concentrations in the general population. Therefore, validated analytical methods for the determination of lower lead concentrations in blood (<150 μg/L) are needed. In addition, new ISO standards require that laboratories determine and specify the uncertainty of their results. Methods: We validated a method to determine lead in blood at concentrations up to 150 μg/L by electrothermal atomic absorption spectrometry with Zeeman background correction according to EURACHEM guidelines. Blood samples were diluted (1:1 by volume) with 2 mL/L Triton X-100. NH4H2PO4 (5 g/L) and Mg(NO3)2 (0.5 g/L) were used as modifiers. Matrix-matched standards were used for calibration. Results: We determined the limits of detection (3.1 μg/L) and quantification (9.4 μg/L). Repeatability and intermediate imprecision within the range 35–150 μg/L were <5.5% and <6.0%, respectively. We assessed trueness by use of certified reference materials, by recovery tests, and by comparison with target values of other reference materials (candidate external quality assessment samples). The expanded uncertainty ranged from 20% to 16% (with a confidence level of 95%) depending on concentration. Conclusions: This study provides a working example of the estimate of uncertainty from method performance data according to the EURACHEM/CITAC guidelines. The estimated uncertainty is compatible with quality specifications for the analysis of lead in blood adopted in the US and the European Union.

scholarly journals Microbiological reference material (bacterial and fungal domains): Definition, production rules, use and need for establishment in Brazil

2019 ◽  
Vol 22 ◽  
Author(s):  
Carla de Oliveira Rosas ◽  
Janaína Marques Rodrigues ◽  
Marcus Henrique Campino de la Cruz ◽  
Silvia Maria dos Reis Lopes ◽  
Aline da Silva Soares Souto ◽  
...  
Keyword(s):  
Quality Control ◽  
Reference Materials ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Proficiency Tests ◽  
Culture Collections ◽  
Test Items ◽  
Incentive Policies ◽  
Reference Strains ◽  
Practical Recommendations

Abstract Reference materials are crucial for laboratory quality assurance. They are widely used for the internal quality control of analytical tests, in the validation of methodologies and as test items in proficiency tests. Microbiological reference materials are represented mainly by reference strains, whose use in laboratory internal quality control is unquestionable and recommended by several microbiological manuals. In Brazil, the practice of producing microbiological reference materials has advanced in recent years in the development of specific materials for proficiency testing. However, the same did not occur with the establishment of reference strains due to a lack of incentive policies, maintaining the country dependant on the use of international reference strains. This article aims to emphasize the importance of the use of microbiological reference materials in laboratory quality control and discuss the need for the development of such materials in Brazil. The paper presents a brief explanation of microbiological reference materials and points out questions concerning the country’s dependence on the acquisition of international biological materials. It also describes quality standards related to the production of these materials and the situation of culture collections and Brazilian reference laboratories that supply reference strains. The study also mentions practical recommendations on the subcultures of reference strains.

Applying The Best Practice For Internal Quality Control (IQC) Management, Consolidation And Review Process In Sidra Medicine Clinical Chemistry Division

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S91-S91
Author(s):  
J M Asinas
Keyword(s):  
Quality Control ◽  
Real Time ◽  
Best Practice ◽  
Clinical Chemistry ◽  
Internal Quality Control ◽  
Internal Quality ◽  
Allowable Error ◽  
Chemistry Division ◽  
Set Up ◽  
High Level

Abstract Introduction/Objective The management of internal quality control (IQC) in Sidra Medicine Clinical Chemistry Division has been evaluated in order to promote a more consolidated and efficient process of IQC management. The statistical data produced from Cerner QC Module are transferred to IQC review templates consisting of formulas to auto- calculate parameters such as multiple of expected QC failure frequency and desirable comparison limit between analyzers. The IQC review and documentation process using the in-house excel template requires several hours to complete, hence a faster and more efficient IQC management module is required. The main objective of this study is to improve the initial IQC management set up, work flow and review procedures and to implement Biorad Unity Real Time (URT) program to develop a more efficient IQC management system. Methods The URT software has been recently configured and implemented to consolidate and streamline IQC management. URT is built through Sidra Medicine IT Enterprise level which allows multiple users to login. IQC data are downloaded using scripts from Cerner which are filtered through Biorad Unity Connect (UC) software. Additional quality tools are also explored such as various user defined statistical reports, IQC analysis using peer reviewed total allowable error (TeA) and assignment of the most appropriate Westgard rules. Determination of sigma metrics and uncertainty of measurement is also performed using the URT application. Results The generation of any IQC report is less cumbersome and time consuming as compared with the previous process. However, some user defined formulas in the IQC templates are not found on the URT reports. The URT Levey Jennings chart are also more user friendly and directly compares the daily IQC data with Unity inter-laboratory peers enabling the production of instant and monthly reports through QCNet site when assay investigation is required and for IQC report documentation. Conclusion The combination of Cerner IQC, Unity Real-time, QCNet Inter-laboratory reports and in house IQC templates produce a high level and very detailed IQC review which effectively evaluate assay performance to assist on IQC troubleshooting and root cause analysis to be able to apply the most appropriate corrective actions.

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