scholarly journals The role of parasympathetic regulation in the fluid secretion of lacrimal gland ducts in mice

2020 ◽  
Author(s):  
Orsolya Berczeli
Keyword(s):  
Lacrimal Gland ◽  
Fluid Secretion ◽  
Parasympathetic Regulation

Role of Th2 Cells in IgG4-Related Lacrimal Gland Enlargement

2010 ◽  
Vol 152 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Hiroko Kanari ◽  
Shin-ichiro Kagami ◽  
Daisuke Kashiwakuma ◽  
Yoshihiro Oya ◽  
Shunsuke Furuta ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Th2 Cells ◽  
Gland Enlargement

scholarly journals Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9

Cells ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 153 ◽  
Author(s):  
Raquel Bernardino ◽  
David Carrageta ◽  
Ana Silva ◽  
Giuseppe Calamita ◽  
Marco Alves ◽  
...  
Keyword(s):  
Sertoli Cells ◽  
Reproductive Tract ◽  
Fluid Secretion ◽  
Male Reproductive Tract ◽  
Aquaporin 9 ◽  
Important Regulator ◽  
17Β Estradiol ◽  
And Function ◽  
Glycerol Permeability

High 17β-Estradiol (E2) levels are known to cause alterations of spermatogenesis and environments throughout the male reproductive tract. Sertoli cells (SCs) ensure an adequate environment inside the seminiferous tubule. Glycerol stands as essential for the maintenance of blood–testis barrier created by SCs, however, the role of E2 in this process is not known. Herein, we hypothesized that the effect of E2 on glycerol permeability in mouse SCs (mSCs) could be mediated by aquaglyceroporins. The expression of aquaglyceroporins was assessed by RT-PCR and qRT-PCR. Glycerol permeability was evaluated by stopped-flow light scattering. We were able to identify the expression of AQP3 and AQP9 in mSCs where AQP9 is more abundant than AQP3. Our results show that high E2 levels decrease AQP9 mRNA abundance with no influence on AQP3 in mSCs. Interestingly, high E2 levels decreased mSCs’ permeability to glycerol, while downregulating AQP9 expression, thus suggesting a novel mechanism by which E2 modulates fluid secretion in the testis. In conclusion, E2 is an important regulator of mSCs physiology and secretion through changes in AQP9 expression and function. Thus, alterations in glycerol permeability induced by E2 may be the cause for male infertility in cases associated with the presence of high E2 levels.

Net fluid secretion in proximal straight renal tubules in vitro: role of PAH

1974 ◽  
Vol 226 (1) ◽  
pp. 191-197 ◽  
Author(s):  
JJ Grantham ◽  
PB Qualizza ◽  
RL Irwin
Keyword(s):  
Fluid Secretion ◽  
Renal Tubules

Preliminary isolation of mosquito natriuretic factor

1985 ◽  
Vol 249 (4) ◽  
pp. R379-R386 ◽  
Author(s):  
D. H. Petzel ◽  
H. H. Hagedorn ◽  
K. W. Beyenbach
Keyword(s):  
Fluid Secretion ◽  
Malpighian Tubules ◽  
Reverse Phase Hplc ◽  
Saline Extract ◽  
Natriuretic Factor ◽  
K Secretion ◽  
Transepithelial Voltage ◽  
Nacl Secretion ◽  
Fraction I

A natriuretic factor that triggers diuresis in isolated Malpighian tubules of the mosquito was isolated from the head of the yellow-fever mosquito Aedes aegypti by passing a saline extract of mosquito heads through low-pressure and then high-pressure liquid chromatography (HPLC) columns. Three fractions with biologic activity eluted during a reverse-phase HPLC linear acetonitrile gradient run. Fraction I depolarized the transepithelial voltage (Vt) of isolated perfused Malpighian tubules but did not not stimulate fluid secretion in the Ramsay assay (J. A. Ramsay, J. Exp. Biol. 31: 104–113, 1954). Fraction II depolarized and fraction III hyperpolarized Vt, and both stimulated fluid secretion three- to fourfold. Even though the effects of fractions II and III on Vt differed, both stimulated fluid secretion by increasing the rate of NaCl secretion without affecting K secretion. The selective stimulation of active secretory Na transport by fraction III is mimicked by cyclic AMP (cAMP), suggesting the second messenger role of cAMP in the effects of fraction III. Because fraction III stimulates a NaCl-rich, as opposed to KCl-rich, fluid, the term mosquito natriuretic factor is proposed for this active fraction.

scholarly journals Experimental Evidence of Fluid Secretion of Rabbit Lacrimal Gland Duct Epithelium

2014 ◽  
Vol 55 (7) ◽  
pp. 4360 ◽  
Author(s):  
Máté Katona ◽  
Eszter Vizvári ◽  
Lukács Németh ◽  
Andrea Facskó ◽  
Viktória Venglovecz ◽  
...  
Keyword(s):  
Experimental Evidence ◽  
Lacrimal Gland ◽  
Fluid Secretion ◽  
Duct Epithelium ◽  
Gland Duct

scholarly journals Lacrimal gland lymphoma: Role of radiation therapy

2012 ◽  
Vol 5 (1) ◽  
pp. 37
Author(s):  
Aruna Turaka ◽  
MitchellR Smith ◽  
Natasha Townsend
Keyword(s):  
Radiation Therapy ◽  
Lacrimal Gland

Serotonin triggers cAMP and PKA-mediated intracellular calcium waves in Malpighian tubules of Rhodnius prolixus

2014 ◽  
Vol 307 (7) ◽  
pp. R828-R836 ◽  
Author(s):  
Paula Gioino ◽  
Brendan G. Murray ◽  
Juan P. Ianowski
Keyword(s):  
Second Messenger ◽  
Fluid Secretion ◽  
Rhodnius Prolixus ◽  
Malpighian Tubules ◽  
Insect Vector ◽  
Excess Water ◽  
Intracellular Ca ◽  
Single Meal ◽  
Hematophagous Insect

Rhodnius prolixus is a hematophagous insect vector of Chagas disease capable of ingesting up to 10 times its unfed body weight in blood in a single meal. The excess water and ions ingested with the meal are expelled through a rapid postprandial diuresis driven by the Malpighian tubules. Diuresis is triggered by at least two diuretic hormones, a CRF-related peptide and serotonin, which were traditionally believed to trigger cAMP as an intracellular second messenger. Recently, calcium has been suggested to act as a second messenger in serotonin-stimulated Malpighian tubules. Thus, we tested the role of calcium in serotonin-stimulated Malpighian tubules from R. prolixus. Our results show that serotonin triggers cAMP-mediated intracellular Ca2+ waves that were blocked by incubation in Ca2+-free saline containing the cell membrane-permeant Ca2+ chelator BAPTA-AM, or the PKA blocker H-89. Treatment with 8-Br-cAMP triggered Ca2+ waves that were blocked by H-89 and BAPTA-AM. Analysis of the secreted fluid in BAPTA-AM-treated tubules showed a 75% reduction in fluid secretion rate with increased K+ concentration, reduced Na+ concentration. Taken together, the results indicate that serotonin triggers cAMP and PKA-mediated Ca2+ waves that are required for maximal ion transport rate.

scholarly journals Role of Epithelial–Mesenchymal Transition in Repair of the Lacrimal Gland after Experimentally Induced Injury

2012 ◽  
Vol 53 (1) ◽  
pp. 126 ◽  
Author(s):  
Samantha You ◽  
Orna Avidan ◽  
Ayesha Tariq ◽  
Ivy Ahluwalia ◽  
Paul C. Stark ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Experimentally Induced
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